STRINGSTRING
RNF125 RNF125 ZNF385D-2 ZNF385D-2 BRD7 BRD7 RFWD3 RFWD3 BLM BLM GATA1 GATA1 TP53 TP53 MUC1-2 MUC1-2 GLTSCR2 GLTSCR2 BCL2L12 BCL2L12 USP7 USP7 PRMT5 PRMT5 Y1Q_0006003 Y1Q_0006003 SMARCB1 SMARCB1 TRIAP1 TRIAP1 RCHY1 RCHY1 RFFL RFFL DAXX DAXX Y1Q_0004744 Y1Q_0004744 DUSP26 DUSP26 PTTG1IP PTTG1IP SETD7 SETD7 CREBBPA CREBBPA CREBBP CREBBP Y1Q_0024039 Y1Q_0024039 TRIM24-2 TRIM24-2 NUAK1 NUAK1 USP10 USP10 ARMC10-1 ARMC10-1 Y1Q_0006637 Y1Q_0006637 TAF3 TAF3 TRIM29 TRIM29 MAPKAPK5 MAPKAPK5 RNF34 RNF34 TP53RK TP53RK ANKRD1 ANKRD1 SIRT1 SIRT1 STK11 STK11 SMYD2 SMYD2 PPP1R13B PPP1R13B MSX1 MSX1 HTT HTT Y1Q_0013170 Y1Q_0013170 MDM2 MDM2 ZMPSTE24 ZMPSTE24 Y1Q_0010122 Y1Q_0010122 EHMT1 EHMT1 TP63 TP63 TP53BP1-1 TP53BP1-1 MUL1 MUL1 EHMT2 EHMT2 MDM4 MDM4 ZNF385B ZNF385B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF125E3 ubiquitin-protein ligase RNF125 isoform A. (250 aa)
ZNF385D-2U1-type domain-containing protein. (92 aa)
BRD7Bromodomain-containing protein 7 isoform A. (664 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (1252 aa)
BLMBloom syndrome protein. (1213 aa)
GATA1Erythroid transcription factor. (485 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
MUC1-2Uncharacterized protein. (143 aa)
GLTSCR2Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (409 aa)
BCL2L12Bcl-2-like protein 12. (377 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1080 aa)
PRMT5Protein arginine N-methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (242 aa)
Y1Q_0006003Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (688 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (386 aa)
TRIAP1TP53-regulated inhibitor of apoptosis 1. (76 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1. (210 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (348 aa)
DAXXDeath domain-associated protein 6 isoform A. (758 aa)
Y1Q_0004744Protein kinase domain-containing protein. (161 aa)
DUSP26Dual specificity protein phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (245 aa)
PTTG1IPPituitary tumor-transforming 1 protein-interacting protein isoform B. (168 aa)
SETD7Histone-lysine N-methyltransferase SETD7. (392 aa)
CREBBPACREB-binding protein isoform A. (1756 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
TRIM24-2Uncharacterized protein. (951 aa)
NUAK1NUAK family SNF1-like kinase 1. (651 aa)
USP10Ubiquitin carboxyl-terminal hydrolase. (665 aa)
ARMC10-1Armadillo repeat-containing protein 10 isoform B. (322 aa)
Y1Q_0006637PRMT5_TIM domain-containing protein. (211 aa)
TAF3Transcription initiation factor TFIID subunit 3 isoform C. (1040 aa)
TRIM29Tripartite motif-containing protein 29 isoform A. (600 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform B. (510 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (345 aa)
TP53RKTP53-regulating kinase. (383 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (418 aa)
SMYD2N-lysine methyltransferase SMYD2. (382 aa)
PPP1R13BApoptosis-stimulating of p53 protein 1. (1153 aa)
MSX1Homeobox protein MSX-1. (256 aa)
HTTHuntingtin isoform A. (3112 aa)
Y1Q_0013170Uncharacterized protein. (100 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (494 aa)
ZMPSTE24CAAX prenyl protease 1-like protein. (1233 aa)
Y1Q_0010122Uncharacterized protein. (300 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (931 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
TP53BP1-1Tumor suppressor p53-binding protein 1 isoform A. (2124 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (355 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform A. (1311 aa)
MDM4Protein Mdm4. (513 aa)
ZNF385BZinc finger protein 385B isoform B. (505 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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