STRINGSTRING
NUP35 NUP35 NUP98 NUP98 KPNA1 KPNA1 NUP133 NUP133 KPNA5 KPNA5 Y1Q_0018930 Y1Q_0018930 SQSTM1 SQSTM1 SYK-2 SYK-2 SNUPN-1 SNUPN-1 PML PML CRY2-2 CRY2-2 IPO7 IPO7 NUP188 NUP188 NUP214 NUP214 PPP3R1 PPP3R1 TPR TPR TRAF3IP2 TRAF3IP2 SEC13 SEC13 KPNA6 KPNA6 NUP54 NUP54 NUP93 NUP93 IPO13 IPO13 POLA2 POLA2 AKIRIN2 AKIRIN2 Y1Q_0016716 Y1Q_0016716 TP53 TP53 NUP155 NUP155 IPO11 IPO11 ABRA ABRA STK4 STK4 APPL1 APPL1 NUP153-1 NUP153-1 TSC2 TSC2 KPNA7-2 KPNA7-2 KPNA7 KPNA7 NUP85 NUP85 EIF4ENIF1 EIF4ENIF1 TNPO3 TNPO3 RPAIN RPAIN NUP88 NUP88 NF1 NF1 TNPO2 TNPO2 IPO9 IPO9 SHISA4 SHISA4 KPNA3 KPNA3 KPNA3-2 KPNA3-2 IPO4 IPO4 ELAVL1 ELAVL1 Y1Q_0008002 Y1Q_0008002 PTTG1IP PTTG1IP APPL2 APPL2 IPO8 IPO8 NUTF2 NUTF2 GPN2 GPN2 NFKBIA NFKBIA HIKESHI HIKESHI NUP62CL NUP62CL Y1Q_0017137 Y1Q_0017137 NXT2 NXT2 LRRK2 LRRK2 SMO SMO TMCO6 TMCO6 IPO5 IPO5 RAN RAN GPN3 GPN3 TXNIP TXNIP POM121 POM121 Y1Q_0006945 Y1Q_0006945 RANBP2 RANBP2 ING1 ING1 STK4-2 STK4-2 CSE1L CSE1L Y1Q_0002793 Y1Q_0002793 GLI3 GLI3 Y1Q_0017512 Y1Q_0017512 Y1Q_0017513 Y1Q_0017513 FAM53B FAM53B MED1 MED1 MED1-2 MED1-2 NUP50 NUP50 FAM53A-1 FAM53A-1 STAT4 STAT4 NUP107 NUP107 TNPO1 TNPO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUP35Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (325 aa)
NUP98Nuclear pore complex protein Nup98-Nup96 isoform A. (1816 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (515 aa)
NUP133Nuclear pore complex protein Nup133. (1154 aa)
KPNA5Importin subunit alpha; Belongs to the importin alpha family. (539 aa)
Y1Q_0018930Actin-binding Rho-activating protein-like. (158 aa)
SQSTM1Sequestosome-1. (457 aa)
SYK-2Tyrosine-protein kinase. (608 aa)
SNUPN-1Snurportin-1 isoform B. (369 aa)
PMLProtein PML isoform B. (586 aa)
CRY2-2Photolyase/cryptochrome alpha/beta domain-containing protein. (547 aa)
IPO7Importin N-terminal domain-containing protein. (1056 aa)
NUP188Nucleoporin NUP188-like protein isoform A. (1740 aa)
NUP214Nuclear pore complex protein Nup214 isoform A. (1560 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
TPRNucleoprotein TPR isoform A. (2325 aa)
TRAF3IP2Adapter protein CIKS. (557 aa)
SEC13SEC13-like protein; Belongs to the WD repeat SEC13 family. (320 aa)
KPNA6Importin subunit alpha; Belongs to the importin alpha family. (551 aa)
NUP54Nucleoporin p54. (502 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (851 aa)
IPO13Importin-13. (527 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (597 aa)
AKIRIN2Akirin-2. (140 aa)
Y1Q_0016716Uncharacterized protein. (178 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
NUP155Nuclear pore complex protein Nup155. (1383 aa)
IPO11Importin-11 isoform B. (1010 aa)
ABRAActin-binding Rho-activating protein. (402 aa)
STK4Serine/threonine-protein kinase 4. (490 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
NUP153-1Nuclear pore complex protein Nup153 isoform B. (1292 aa)
TSC2Tuberin isoform D. (1829 aa)
KPNA7-2Importin subunit alpha; Belongs to the importin alpha family. (518 aa)
KPNA7Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (620 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter. (967 aa)
TNPO3Transportin-3 isoform B. (923 aa)
RPAINRPA-interacting protein. (217 aa)
NUP88Nuclear pore complex protein Nup88. (612 aa)
NF1Neurofibromin isoform B. (2879 aa)
TNPO2Transportin-2. (996 aa)
IPO9Importin-9 isoform A. (1057 aa)
SHISA4Protein shisa-4. (197 aa)
KPNA3Importin subunit alpha; Belongs to the importin alpha family. (504 aa)
KPNA3-2Importin subunit alpha; Belongs to the importin alpha family. (533 aa)
IPO4Importin-4. (557 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (334 aa)
Y1Q_0008002Nuclear transport factor 2-like. (122 aa)
PTTG1IPPituitary tumor-transforming 1 protein-interacting protein isoform B. (168 aa)
APPL2Uncharacterized protein. (659 aa)
IPO8Importin-8. (1017 aa)
NUTF2Nuclear transport factor 2. (127 aa)
GPN2GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (308 aa)
NFKBIANF-kappa-B inhibitor alpha. (299 aa)
HIKESHIProtein Hikeshi. (197 aa)
NUP62CLNucleoporin-62 C-terminal-like protein. (584 aa)
Y1Q_0017137Importin-4-like. (551 aa)
NXT2NTF2-related export protein 2. (141 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (804 aa)
TMCO6Transmembrane and coiled-coil domain-containing protein 6. (492 aa)
IPO5Importin-5. (1098 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (271 aa)
GPN3GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (284 aa)
TXNIPThioredoxin-interacting protein. (391 aa)
POM121Nuclear envelope pore membrane protein POM 121C. (522 aa)
Y1Q_0006945Importin N-terminal domain-containing protein. (317 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (2133 aa)
ING1Inhibitor of growth protein. (281 aa)
STK4-2Protein kinase domain-containing protein. (416 aa)
CSE1LExportin-2. (998 aa)
Y1Q_0002793SARAH domain-containing protein. (108 aa)
GLI3Uncharacterized protein. (1572 aa)
Y1Q_0017512Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (345 aa)
Y1Q_0017513Mediator of RNA polymerase II transcription subunit 1-like. (204 aa)
FAM53BProtein FAM53B. (283 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1104 aa)
MED1-2Uncharacterized protein. (259 aa)
NUP50Nuclear pore complex protein Nup50. (520 aa)
FAM53A-1Protein FAM53A isoform B. (435 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (859 aa)
TNPO1Importin N-terminal domain-containing protein. (937 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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