(74 nodes) Endoplasmic reticulum organization network (Alligator mississippiensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	REEP5	Receptor expression-enhancing protein. (190 aa)
	UBL4A	Ubiquitin-like protein 4A. (158 aa)
	LNPB	Protein lunapark. (418 aa)
	ESYT3	Extended synaptotagmin-3 isoform C. (775 aa)
	ATL2	GB1/RHD3-type G domain-containing protein. (583 aa)
	PCNXL4	Pecanex-like protein 4 isoform B. (972 aa)
	Y1Q_0009226	Pecanex_C domain-containing protein. (815 aa)
	PCNX2	Uncharacterized protein. (1342 aa)
	EMC10	ER membrane protein complex subunit 10 isoform B. (283 aa)
	BNIP1	Vesicle transport protein SEC20. (228 aa)
	CAMLG	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (257 aa)
	PCNX3	Uncharacterized protein. (600 aa)
	POLR2M	Protein GRINL1A. (368 aa)
	PCNX1	Pecanex_C domain-containing protein. (2339 aa)
	LPCAT3	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (474 aa)
	PEX5	Peroxisomal biogenesis factor 5 isoform A. (646 aa)
	WRB	Tail-anchored protein insertion receptor WRB. (170 aa)
	SEC16A	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1977 aa)
	REEP2	Receptor expression-enhancing protein. (292 aa)
	SEC16B	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1065 aa)
	EMC1	ER membrane protein complex subunit 1. (1009 aa)
	EMC4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (183 aa)
	SEC31A	Protein transport protein Sec31A. (1248 aa)
	GRAMD2	GRAM domain-containing protein 2 isoform A. (329 aa)
	ZFYVE27	Protrudin. (328 aa)
	TRAM1	Translocating chain-associated membrane protein 1. (388 aa)
	VCPIP1	Deubiquitinating protein VCIP135. (1078 aa)
	TMEM170A-1	Transmembrane protein 170A isoform B. (136 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (302 aa)
	REEP3	Receptor expression-enhancing protein. (257 aa)
	EMC7	ER membrane protein complex subunit 7. (207 aa)
	ESYT1	Extended synaptotagmin-1. (531 aa)
	RNF112	RING finger protein 112. (640 aa)
	LMAN1	Protein ERGIC-53. (502 aa)
	EMC2	ER membrane protein complex subunit 2. (297 aa)
	RNF112L	RING finger protein 112. (527 aa)
	GET4	Golgi to ER traffic 4-like protein. (283 aa)
	FAM134A	Protein FAM134A. (495 aa)
	ATL1	GB1/RHD3-type G domain-containing protein. (553 aa)
	SMPD4	Sphingomyelin phosphodiesterase 4 isoform A. (829 aa)
	ASNA1	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (350 aa)
	MMGT1	Membrane magnesium transporter 1. (133 aa)
	TRAM2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (373 aa)
	Y1Q_0017188	Uncharacterized protein. (164 aa)
	Y1Q_0020951	Uncharacterized protein. (453 aa)
	WDR83OS	Protein Asterix. (101 aa)
	GAK-2	Uncharacterized protein. (1325 aa)
	TMEM38B	Trimeric intracellular cation channel type B. (288 aa)
	FAM134B	Reticulophagy receptor FAM134B. (463 aa)
	EMC9	ER membrane protein complex subunit 9. (141 aa)
	EMC8	ER membrane protein complex subunit 8. (202 aa)
	Y1Q_0010364	Uncharacterized protein. (67 aa)
	EMC6	ER membrane protein complex subunit 6. (111 aa)
	CUNHXorf56	Uncharacterized protein. (233 aa)
	IL17RE	Interleukin-17 receptor E. (1282 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
	Y1Q_0016976	Uncharacterized protein. (365 aa)
	TMED2	Transmembrane emp24 domain-containing protein 2 isoform B. (201 aa)
	LMAN2L	VIP36-like protein. (336 aa)
	SHTN1	Shootin-1 isoform A. (613 aa)
	LMAN2	Vesicular integral-membrane protein VIP36. (285 aa)
	BAG6	Large proline-rich protein BAG6. (945 aa)
	VAPB	Vesicle-associated membrane protein-associated protein B/C. (228 aa)
	Y1Q_0002765	Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
	SEC31A-2	WD_REPEATS_REGION domain-containing protein. (1252 aa)
	ATL3	Atlastin-3. (677 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform B. (976 aa)
	PCNXL2	Pecanex-like protein 2. (591 aa)
	STX18	Syntaxin-18. (348 aa)
	REEP1	Receptor expression-enhancing protein. (198 aa)
	TMEM33	Transmembrane protein 33. (251 aa)
	CCDC47	Coiled-coil domain-containing protein 47 isoform B. (533 aa)
	ESYT2	Uncharacterized protein. (796 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNA1	BAG6	A0A151N647	A0A151NWF2	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Large proline-rich protein BAG6.	0.673
ASNA1	CAMLG	A0A151N647	A0A151M717	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.	0.930
ASNA1	EMC3	A0A151N647	A0A151MTH6	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.597
ASNA1	EMC6	A0A151N647	A0A151NMS4	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	ER membrane protein complex subunit 6.	0.585
ASNA1	GET4	A0A151N647	A0A151N1H5	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Golgi to ER traffic 4-like protein.	0.990
ASNA1	UBL4A	A0A151N647	A0A151LZE0	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Ubiquitin-like protein 4A.	0.742
ASNA1	WRB	A0A151N647	A0A151ME91	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Tail-anchored protein insertion receptor WRB.	0.992
ASNA1	Y1Q_0017188	A0A151N647	A0A151NCQ2	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Uncharacterized protein.	0.673
ATL1	REEP1	A0A151N3F2	A0A151PA28	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.681
ATL1	REEP2	A0A151N3F2	A0A151MID4	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.548
ATL1	REEP3	A0A151N3F2	A0A151MUF6	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.742
ATL2	REEP1	A0A151M1L8	A0A151PA28	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.681
ATL2	REEP2	A0A151M1L8	A0A151MID4	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.548
ATL2	REEP3	A0A151M1L8	A0A151MUF6	GB1/RHD3-type G domain-containing protein.	Receptor expression-enhancing protein.	0.742
ATL3	REEP1	A0A151P4V4	A0A151PA28	Atlastin-3.	Receptor expression-enhancing protein.	0.681
ATL3	REEP2	A0A151P4V4	A0A151MID4	Atlastin-3.	Receptor expression-enhancing protein.	0.548
ATL3	REEP3	A0A151P4V4	A0A151MUF6	Atlastin-3.	Receptor expression-enhancing protein.	0.742
BAG6	ASNA1	A0A151NWF2	A0A151N647	Large proline-rich protein BAG6.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.673
BAG6	GET4	A0A151NWF2	A0A151N1H5	Large proline-rich protein BAG6.	Golgi to ER traffic 4-like protein.	0.920
BAG6	UBL4A	A0A151NWF2	A0A151LZE0	Large proline-rich protein BAG6.	Ubiquitin-like protein 4A.	0.871