STRINGSTRING
ITGA3-2 ITGA3-2 Y1Q_0017506 Y1Q_0017506 CTNNB1 CTNNB1 DKK1 DKK1 LRP5 LRP5 VTN VTN APLNR APLNR DUSP5 DUSP5 NR0B1 NR0B1 UGDH UGDH KDM6B KDM6B EXOC4 EXOC4 EXOC4-2 EXOC4-2 NPM3 NPM3 WNT11B WNT11B ARMC5-2 ARMC5-2 CDC73 CDC73 TAB2 TAB2 HAND1 HAND1 TL TL TWSG1 TWSG1 GPR25L GPR25L NODAL NODAL Y1Q_0018553 Y1Q_0018553 CUL3 CUL3 ITGAV-2 ITGAV-2 WNT3-2 WNT3-2 POFUT2 POFUT2 FN1 FN1 BMPR2 BMPR2 GPI GPI APLN APLN ATOH8 ATOH8 UGDH-2 UGDH-2 HNF1B HNF1B TENM4 TENM4 Y1Q_0007089 Y1Q_0007089 NF2 NF2 KDM6B-2 KDM6B-2 ITGB4 ITGB4 ARFRP1-1 ARFRP1-1 PAF1 PAF1 FAM208A FAM208A MMP14 MMP14 TAF10 TAF10 SMAD2-2 SMAD2-2 Y1Q_0009747 Y1Q_0009747 TP53 TP53 SOX7 SOX7 RTF1 RTF1 GNB2L1 GNB2L1 SETD2 SETD2 Y1Q_0014200 Y1Q_0014200 MMP15-2 MMP15-2 ITGA5 ITGA5 TGFBR2-2 TGFBR2-2 EOMES EOMES DUSP4 DUSP4 SUPT20H SUPT20H SYF2 SYF2 MMP9 MMP9 LAMB3 LAMB3 EPHA2 EPHA2 ZBTB17 ZBTB17 LEF1 LEF1 KIF16B-2 KIF16B-2 CRB2 CRB2 POGLUT1 POGLUT1 COL8A1 COL8A1 TBX19 TBX19 CTR9 CTR9 EXT2 EXT2 LEO1 LEO1 SMAD3 SMAD3 CFC1B CFC1B TDGF1 TDGF1 DUSP1 DUSP1 ARMC5-1 ARMC5-1 PLPP3 PLPP3 WNT11 WNT11 T T EPB41L4B EPB41L4B TGFBR2 TGFBR2 ITGB5 ITGB5 ACVR2A ACVR2A ACVR1-2 ACVR1-2 ITGA4 ITGA4 WNT3 WNT3 Y1Q_0017180 Y1Q_0017180 SFRP2 SFRP2 MSGN1 MSGN1 SMAD4 SMAD4 SMAD1 SMAD1 ITGB3-2 ITGB3-2 ACVR2B ACVR2B FGF2 FGF2 FRS2 FRS2 HMGA2 HMGA2 Y1Q_0020742 Y1Q_0020742 S1PR2 S1PR2 GATA6 GATA6 NAT8B NAT8B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA3-2Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1085 aa)
Y1Q_0017506TGF_BETA_2 domain-containing protein. (424 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
DKK1Dickkopf-related protein 1. (103 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
VTNVitronectin. (324 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (130 aa)
UGDHUDP-glucose 6-dehydrogenase. (305 aa)
KDM6BLysine-specific demethylase 6B isoform A. (1401 aa)
EXOC4Exocyst complex component 4. (357 aa)
EXOC4-2Uncharacterized protein. (587 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
WNT11BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (811 aa)
ARMC5-2Armadillo repeat-containing protein 5. (207 aa)
CDC73Parafibromin. (531 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (276 aa)
HAND1Heart-and neural crest derivatives-expressed protein 1. (183 aa)
TLBrachyury protein isoform B. (432 aa)
TWSG1Twisted gastrulation protein-like protein 1. (273 aa)
GPR25LApelin receptor A-like isoform A; Belongs to the G-protein coupled receptor 1 family. (329 aa)
NODALNodal-like protein. (353 aa)
Y1Q_0018553Integrin alpha-5-like. (167 aa)
CUL3Cullin-3; Belongs to the cullin family. (768 aa)
ITGAV-2Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
WNT3-2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
POFUT2GDP-fucose protein O-fucosyltransferase 2. (413 aa)
FN1Fibronectin isoform A. (2483 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
APLNApelin. (70 aa)
ATOH8Atonal-like protein 8. (66 aa)
UGDH-2UDPG_MGDP_dh_N domain-containing protein. (102 aa)
HNF1BHomeobox domain-containing protein. (562 aa)
TENM4Uncharacterized protein. (2883 aa)
Y1Q_0007089FERM domain-containing protein. (665 aa)
NF2Merlin isoform A. (593 aa)
KDM6B-2Uncharacterized protein. (1393 aa)
ITGB4Integrin beta. (1833 aa)
ARFRP1-1ADP-ribosylation factor-related protein 1 isoform B. (217 aa)
PAF1RNA polymerase II-associated factor 1-like protein. (503 aa)
FAM208AProtein TASOR isoform E. (1563 aa)
MMP14ZnMc domain-containing protein. (570 aa)
TAF10Transcription initiation factor TFIID subunit 10. (121 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
SOX7Transcription factor SOX-7. (378 aa)
RTF1RNA polymerase-associated RTF1-like protein. (233 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform C. (1911 aa)
Y1Q_0014200Nuclear receptor subfamily 0 group B member 2-like. (369 aa)
MMP15-2ZnMc domain-containing protein. (709 aa)
ITGA5Integrin alpha-5. (671 aa)
TGFBR2-2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
EOMESEomesodermin-like protein isoform B. (404 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (373 aa)
SUPT20HTranscription factor SPT20-like protein isoform C. (811 aa)
SYF2Pre-mRNA-splicing factor SYF2. (245 aa)
MMP9Uncharacterized protein. (684 aa)
LAMB3Laminin subunit beta-3 isoform B. (1232 aa)
EPHA2Uncharacterized protein. (979 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform A. (790 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
KIF16B-2Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1320 aa)
CRB2Crumbs-like protein 2 isoform A. (1508 aa)
POGLUT1Protein O-glucosyltransferase 1. (387 aa)
COL8A1Collagen alpha-1(VIII) chain. (761 aa)
TBX19T-box transcription factor TBX19. (600 aa)
CTR9RNA polymerase-associated CTR9-like protein. (1135 aa)
EXT2Exostosin-2; Belongs to the glycosyltransferase 47 family. (701 aa)
LEO1RNA polymerase-associated protein LEO1. (653 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
CFC1BCryptic protein. (195 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (336 aa)
ARMC5-1Armadillo repeat-containing protein 5. (628 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (314 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
TBrachyury protein. (435 aa)
EPB41L4BBand 4.1-like protein 4B isoform B. (794 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (498 aa)
ACVR1-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1036 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
Y1Q_0017180Putative N-acetyltransferase camello. (221 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
MSGN1Mesogenin-1. (172 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
HMGA2High mobility group protein HMGI-C. (112 aa)
Y1Q_0020742Uncharacterized protein. (68 aa)
S1PR2Sphingosine 1-phosphate receptor 2. (204 aa)
GATA6Transcription factor GATA-6. (325 aa)
NAT8BN-acetyltransferase 8B isoform A. (489 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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