STRINGSTRING
MTTP MTTP Y1Q_0006637 Y1Q_0006637 Y1Q_0010332 Y1Q_0010332 NAMPT NAMPT HUWE1 HUWE1 HDAC3 HDAC3 PPP1CC PPP1CC OGT OGT PER1 PER1 Y1Q_0011874 Y1Q_0011874 FAM155A-2 FAM155A-2 SIRT6 SIRT6 NPAS2 NPAS2 NMS-1 NMS-1 Y1Q_0020147 Y1Q_0020147 MC3R MC3R TOP1-2 TOP1-2 SIRT1 SIRT1 HTR7-2 HTR7-2 BTBD9 BTBD9 PPP1CA PPP1CA Y1Q_0020627 Y1Q_0020627 METTL3 METTL3 ZPBP2 ZPBP2 NGFR NGFR Y1Q_0019415 Y1Q_0019415 EGR3 EGR3 NUDT12 NUDT12 HOMER1 HOMER1 ATF5 ATF5 THRAP3 THRAP3 NTRK1 NTRK1 NR1D1 NR1D1 NDUFA9 NDUFA9 PPARAB PPARAB PAX4 PAX4 PPARGC1A PPARGC1A PASD1 PASD1 CREBBP CREBBP NOCT NOCT CRY2 CRY2 DRD2 DRD2 RAI1 RAI1 PRMT5 PRMT5 KDM8 KDM8 HTR7 HTR7 KLF10 KLF10 TP53 TP53 GPR176 GPR176 NRADD NRADD EGR2 EGR2 PPP1CA-2 PPP1CA-2 NR1D2 NR1D2 AHR AHR BHLHE41 BHLHE41 Y1Q_0001163 Y1Q_0001163 PROK2 PROK2 BHLHE40 BHLHE40 EGR1 EGR1 ID1 ID1 EGR1L EGR1L Y1Q_0018245 Y1Q_0018245 DBP DBP SETX SETX NRIP1 NRIP1 ARNTL ARNTL Y1Q_0000589 Y1Q_0000589 CRY2-2 CRY2-2 CIART CIART PML PML RORA RORA NTRK2 NTRK2 NFIL3 NFIL3 CSNK1E CSNK1E Y1Q_0021893 Y1Q_0021893 RORC RORC Y1Q_0000158 Y1Q_0000158 TNFRSF11A TNFRSF11A Y1Q_0006656 Y1Q_0006656 TIMELESS TIMELESS NR1D4A NR1D4A AHR2 AHR2 NAGLU NAGLU CREB1 CREB1 Y1Q_0008691 Y1Q_0008691 ID2 ID2 PASD1-2 PASD1-2 HNF1B HNF1B MYBBP1A MYBBP1A GPR157 GPR157 AANAT AANAT ATF4-2 ATF4-2 CSNK1E-2 CSNK1E-2 Y1Q_0024039 Y1Q_0024039 CUNH3orf70 CUNH3orf70 CRY1 CRY1 ATF4-1 ATF4-1 KDM5A KDM5A NR0B2 NR0B2 MYCBP2 MYCBP2 Y1Q_0010331 Y1Q_0010331
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTTPMicrosomal triglyceride transfer protein large subunit. (893 aa)
Y1Q_0006637PRMT5_TIM domain-containing protein. (211 aa)
Y1Q_0010332TOPEUc domain-containing protein. (173 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (489 aa)
HUWE1E3 ubiquitin-protein ligase HUWE1. (1590 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit isoform B. (1075 aa)
PER1Period circadian protein-like protein 3. (1366 aa)
Y1Q_0011874Nuclear factor interleukin-3-regulated protein. (302 aa)
FAM155A-2Uncharacterized protein. (121 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
NPAS2Uncharacterized protein. (936 aa)
NMS-1Neuromedin-S preproprotein isoform B. (157 aa)
Y1Q_0020147E3 ubiquitin-protein ligase HUWE1-like. (551 aa)
MC3RMelanocortin receptor 3. (326 aa)
TOP1-2DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (775 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
HTR7-2G_PROTEIN_RECEP_F1_2 domain-containing protein. (167 aa)
BTBD9BTB/POZ domain-containing protein 9. (647 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
Y1Q_0020627Uncharacterized protein. (92 aa)
METTL3N6-adenosine-methyltransferase subunit; Belongs to the MT-A70-like family. (419 aa)
ZPBP2Zona pellucida-binding protein 2. (345 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
Y1Q_0019415Uncharacterized protein. (85 aa)
EGR3Early growth response protein 3. (488 aa)
NUDT12Peroxisomal NADH pyrophosphatase NUDT12. (533 aa)
HOMER1Homer protein-like protein 1. (355 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (293 aa)
THRAP3Thyroid hormone receptor-associated protein 3. (659 aa)
NTRK1Tyrosine-protein kinase receptor. (815 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (555 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (382 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
PAX4Paired box protein Pax-4. (185 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform A. (555 aa)
PASD1Circadian clock protein PASD1. (732 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
NOCTNocturnin. (420 aa)
CRY2Cryptochrome-2. (506 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (434 aa)
RAI1Retinoic acid-induced protein 1. (1935 aa)
PRMT5Protein arginine N-methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (242 aa)
KDM8Lysine-specific demethylase 8. (166 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (426 aa)
KLF10Krueppel-like factor 10. (121 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
GPR176Putative G-protein coupled receptor 176 isoform B. (541 aa)
NRADDTumor necrosis factor receptor superfamily member 16. (408 aa)
EGR2E3 SUMO-protein ligase EGR2. (157 aa)
PPP1CA-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform B. (589 aa)
AHRAryl hydrocarbon receptor. (522 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (80 aa)
Y1Q_0001163Nuclear factor interleukin-3-regulated protein-like. (330 aa)
PROK2Prokineticin-2. (72 aa)
BHLHE40Class E basic helix-loop-helix protein 40 isoform B. (283 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (429 aa)
ID1DNA-binding protein inhibitor ID-1. (68 aa)
EGR1LEarly growth response protein 1. (83 aa)
Y1Q_0018245Timeless-like protein. (364 aa)
DBPD site-binding protein. (307 aa)
SETXPutative helicase senataxin. (1732 aa)
NRIP1Nuclear receptor-interacting protein 1. (391 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B. (651 aa)
Y1Q_0000589LRRNT domain-containing protein. (686 aa)
CRY2-2Photolyase/cryptochrome alpha/beta domain-containing protein. (547 aa)
CIARTCircadian-associated transcriptional repressor. (457 aa)
PMLProtein PML isoform B. (586 aa)
RORANuclear receptor ROR-alpha isoform B. (468 aa)
NTRK2Tyrosine-protein kinase receptor. (817 aa)
NFIL3Nuclear factor interleukin-3-regulated protein isoform A. (442 aa)
CSNK1ECasein kinase I isoform B; Belongs to the protein kinase superfamily. (446 aa)
Y1Q_0021893PAS domain-containing protein. (1057 aa)
RORCNuclear receptor ROR-gamma. (521 aa)
Y1Q_0000158Uncharacterized protein. (139 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (669 aa)
Y1Q_0006656E3 ubiquitin-protein ligase HUWE1-like. (1038 aa)
TIMELESSTimeless-like protein. (616 aa)
NR1D4ANuclear receptor subfamily 1, group D, member 4a. (431 aa)
AHR2Aryl hydrocarbon receptor 2. (1104 aa)
NAGLUAlpha-N-acetylglucosaminidase. (620 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
Y1Q_0008691Uncharacterized protein. (686 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
PASD1-2Uncharacterized protein. (822 aa)
HNF1BHomeobox domain-containing protein. (562 aa)
MYBBP1AMyb-binding protein 1A. (1143 aa)
GPR157Putative G-protein coupled receptor 157. (387 aa)
AANATSerotonin N-acetyltransferase. (205 aa)
ATF4-2Cyclic AMP-dependent transcription factor ATF-4. (124 aa)
CSNK1E-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
CUNH3orf70Uncharacterized protein. (247 aa)
CRY1Cryptochrome 4. (665 aa)
ATF4-1Cyclic AMP-dependent transcription factor ATF-4. (117 aa)
KDM5AUncharacterized protein. (1692 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (266 aa)
MYCBP2E3 ubiquitin-protein ligase MYCBP2 isoform B. (4421 aa)
Y1Q_0010331Topoisom_I_N domain-containing protein. (197 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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