STRINGSTRING
POLD3-1 POLD3-1 Y1Q_0024039 Y1Q_0024039 CREBBP CREBBP CREBBPA CREBBPA CHEK1 CHEK1 XPA XPA RHBDD1 RHBDD1 ATR ATR IL12A IL12A DHX36 DHX36 MEN1 MEN1 PBK PBK WRN WRN NOC2L NOC2L UBE4B UBE4B DCUN1D3 DCUN1D3 ERCC4 ERCC4 ERCC2 ERCC2 TIMP1 TIMP1 ERCC1 ERCC1 TP53INP1-1 TP53INP1-1 ERCC8 ERCC8 PRKAA1-2 PRKAA1-2 TP53 TP53 USF1 USF1 TROVE2 TROVE2 INO80 INO80 EIF2AK4 EIF2AK4 BMF BMF BRCA2 BRCA2 Y1Q_0012270 Y1Q_0012270 PRIMPOL PRIMPOL MMP9 MMP9 ERCC6 ERCC6 XPC XPC CASP9 CASP9 POLH POLH OPN3 OPN3 CUNH9orf116 CUNH9orf116 HYAL3-1 HYAL3-1 USP47 USP47 CCND1 CCND1 CAT CAT DDB2 DDB2 EIF2S1 EIF2S1 UBE2A UBE2A CUL4B CUL4B Y1Q_0015515 Y1Q_0015515 ERCC5 ERCC5 CDKN2D CDKN2D CASP7 CASP7 CUL4A CUL4A MSH2 MSH2 SIRT6 SIRT6 MSH6 MSH6 REV1 REV1 DDB1 DDB1 ACTR5 ACTR5 TMEM161B TMEM161B SIRT1 SIRT1 STK11 STK11 Y1Q_0007595 Y1Q_0007595 SDE2 SDE2 PARP1 PARP1 DTL DTL METTL3 METTL3 BAK1 BAK1 MC1R MC1R PCNA PCNA RHNO1 RHNO1 SMPD1 SMPD1 Y1Q_0016217 Y1Q_0016217 UVSSA UVSSA PPID PPID Y1Q_0021681 Y1Q_0021681 AQP1 AQP1 MFAP4 MFAP4 ZMPSTE24 ZMPSTE24 IMPACT IMPACT POLK POLK OPN5 OPN5 POLD1 POLD1 PML PML PCLAF PCLAF UBE2B UBE2B PTPRM PTPRM MAP2K7 MAP2K7 SPRTN SPRTN MAP3K4 MAP3K4 Y1Q_0000158 Y1Q_0000158 ZBTB1 ZBTB1 ERCC3 ERCC3 Y1Q_0011682 Y1Q_0011682 ZRANB3 ZRANB3 RUVBL2 RUVBL2 BAX BAX Y1Q_0008411 Y1Q_0008411 USP1 USP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD3-1DNA polymerase delta subunit 3 isoform A. (466 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
CREBBPACREB-binding protein isoform A. (1756 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
XPADNA repair protein complementing XP-A cells. (244 aa)
RHBDD1Rhomboid-related protein 4. (221 aa)
ATRSerine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa)
IL12AInterleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (144 aa)
DHX36ATP-dependent RNA helicase DHX36. (991 aa)
MEN1Menin. (456 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (325 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
NOC2LNucleolar complex 2-like protein. (785 aa)
UBE4BUbiquitin conjugation factor E4 B. (1173 aa)
DCUN1D3DCN1-like protein. (304 aa)
ERCC4DNA repair endonuclease XPF. (903 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
TIMP1Metalloproteinase inhibitor 1. (224 aa)
ERCC1DNA excision repair protein ERCC-1. (329 aa)
TP53INP1-1Tumor protein p53-inducible nuclear protein 1 isoform B. (225 aa)
ERCC8DNA excision repair protein ERCC-8. (399 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
USF1Upstream stimulatory factor 1 isoform B. (349 aa)
TROVE2SS-A/Ro ribonucleoprotein. (223 aa)
INO80DNA helicase INO80. (1539 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1613 aa)
BMFBcl-2-modifying factor. (217 aa)
BRCA2Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
Y1Q_0012270Uncharacterized protein. (125 aa)
PRIMPOLDNA-directed primase/polymerase protein. (304 aa)
MMP9Uncharacterized protein. (684 aa)
ERCC6DNA excision repair protein ERCC-6. (1491 aa)
XPCDNA repair protein complementing XP-C cells. (955 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (423 aa)
POLHDNA polymerase eta. (707 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CUNH9orf116Uncharacterized protein. (137 aa)
HYAL3-1Hyaluronidase. (644 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform A; Belongs to the peptidase C19 family. (1356 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
DDB2DNA damage-binding protein 2. (517 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (352 aa)
UBE2AUbiquitin-conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
CUL4BCullin-4B; Belongs to the cullin family. (614 aa)
Y1Q_0015515Cullin domain-containing protein; Belongs to the cullin family. (160 aa)
ERCC5DNA repair protein complementing XP-G cells isoform B. (1152 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (167 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (319 aa)
CUL4ACULLIN_2 domain-containing protein; Belongs to the cullin family. (763 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1340 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1160 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ACTR5Actin-related protein 5; Belongs to the actin family. (557 aa)
TMEM161BTransmembrane protein 161B. (489 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (418 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
SDE2SDE2-like protein. (397 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
DTLDenticleless protein-like protein isoform B. (745 aa)
METTL3N6-adenosine-methyltransferase subunit; Belongs to the MT-A70-like family. (419 aa)
BAK1Bcl-2-like proteinous antagonist/killer. (222 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (318 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RHNO1RAD9. (261 aa)
SMPD1Sphingomyelin phosphodiesterase. (287 aa)
Y1Q_0016217TROVE domain-containing protein. (130 aa)
UVSSAUV-stimulated scaffold protein A. (761 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
Y1Q_0021681Uncharacterized protein. (69 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
MFAP4Microfibril-associated glycoprotein 4. (256 aa)
ZMPSTE24CAAX prenyl protease 1-like protein. (1233 aa)
IMPACTProtein IMPACT isoform B; Belongs to the G-protein coupled receptor 1 family. (511 aa)
POLKDNA polymerase kappa isoform A. (651 aa)
OPN5Opsin-5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
POLD1DNA polymerase. (439 aa)
PMLProtein PML isoform B. (586 aa)
PCLAFPCNA-associated factor. (121 aa)
UBE2BUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform C. (1440 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform C. (488 aa)
SPRTNSprT-like domain-containing protein Spartan. (495 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform A. (1572 aa)
Y1Q_0000158Uncharacterized protein. (139 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (710 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
Y1Q_0011682Uncharacterized protein. (82 aa)
ZRANB3DNA annealing helicase and endonuclease ZRANB3. (1022 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (461 aa)
BAXApoptosis regulator BAX. (209 aa)
Y1Q_0008411Apoptosis regulator BAX-like. (187 aa)
USP1Ubiquitin carboxyl-terminal hydrolase. (798 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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