(102 nodes) Regulation of endothelial cell migration network (Alligator mississippiensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Y1Q_0021456	LRRNT domain-containing protein. (127 aa)
	MET-2	Uncharacterized protein. (1348 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal isoform B. (1024 aa)
	Y1Q_0014445	Junctional protein associated with coronary artery disease. (1337 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (925 aa)
	JUP	Uncharacterized protein. (718 aa)
	MAP3K3-2	Uncharacterized protein. (657 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	FBXW7-2	Uncharacterized protein. (674 aa)
	ATP5B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (493 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
	KDR	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1353 aa)
	ATOH8	Atonal-like protein 8. (66 aa)
	SLIT2	Slit-like protein 2 protein. (1666 aa)
	LGMN	Legumain. (470 aa)
	BMP10	Bone morphogenetic protein 10. (426 aa)
	SP1	Transcription factor Sp1. (746 aa)
	BMPER	BMP-binding endothelial regulator protein isoform A. (677 aa)
	ANGPT2-1	Angiopoietin-2. (495 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (242 aa)
	SEMA4A	Semaphorin-4A; Belongs to the semaphorin family. (777 aa)
	Y1Q_0004478	Sema domain-containing protein. (83 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (369 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (249 aa)
	TNF	Tumor necrosis factor. (231 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (810 aa)
	SASH1	SAM and SH3 domain-containing protein 1 isoform B. (1296 aa)
	ANGPT2	Fibrinogen C-terminal domain-containing protein. (447 aa)
	Y1Q_0008439	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (375 aa)
	PTN	Pleiotrophin. (165 aa)
	PDGFB	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
	SH3BP1	SH3 domain-binding protein 1. (850 aa)
	CARD10	Caspase recruitment domain-containing protein 10 isoform B. (1038 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (389 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (814 aa)
	TEK	Angiopoietin-1 receptor. (1114 aa)
	Y1Q_0017061	Uncharacterized protein. (161 aa)
	RIN2	Ras and Rab interactor 2. (918 aa)
	TBXA2R	Thromboxane A2 receptor. (355 aa)
	ATP2B4-2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1293 aa)
	PDCD10	Programmed cell death protein 10. (225 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	FBXW7	F-box/WD repeat-containing protein 7. (665 aa)
	CIB1	Calcium and integrin-binding protein 1. (190 aa)
	FUT2	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (340 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1. (200 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	NF1	Neurofibromin isoform B. (2879 aa)
	FBXW9	F-box/WD repeat-containing protein 9. (457 aa)
	BCAS3	Breast carcinoma-amplified sequence 3. (190 aa)
	Y1Q_0007194	Uncharacterized protein. (103 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (217 aa)
	PRCP	Lysosomal Pro-X carboxypeptidase. (485 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
	APOH	Beta-2-glycoprotein 1. (350 aa)
	ANGPT2-2	Angiopoietin-2. (498 aa)
	CCBE1	Collagen and calcium-binding EGF domain-containing protein 1. (264 aa)
	ATP5A1	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (548 aa)
	Y1Q_0009788	Uncharacterized protein. (117 aa)
	Y1Q_0015232	UBA_6 domain-containing protein. (145 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (300 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (687 aa)
	THBS2	Thrombospondin-2. (1224 aa)
	SPRED1	Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
	EFNA1	Ephrin-A1; Belongs to the ephrin family. (205 aa)
	BCAR1	Breast cancer anti-estrogen resistance protein 1. (960 aa)
	ACVR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
	KRIT1	Krev interaction trapped protein 1. (730 aa)
	MEOX2	Homeobox protein MOX-2. (207 aa)
	ANXA3	Annexin. (323 aa)
	VASH1	Vasohibin-1. (390 aa)
	GDF2	Growth/differentiation factor 2. (430 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	GLUL	Glutamine synthetase. (373 aa)
	RGCC	Regulator of cell cycle RGCC. (131 aa)
	VEGFA-1	Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
	Y1Q_0005592	Glutamine synthetase. (374 aa)
	AAMP	Angio-associated migratory cell protein. (437 aa)
	IGF2-1	Insulin-like growth factor II isoform B. (217 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
	SYNJ2BP-1	Synaptojanin-2-binding protein. (145 aa)
	MAP2K5	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (446 aa)
	ANXA1	Annexin. (362 aa)
	HRG	Histidine-rich glycoprotein. (428 aa)
	FLT1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1725 aa)
	FGF1-1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	EMC10	ER membrane protein complex subunit 10 isoform B. (283 aa)
	PIK3CB-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
	PLPP3	Lipid phosphate phosphohydrolase 3. (314 aa)
	NUS1	Dehydrodolichyl diphosphate syntase complex subunit NUS1. (177 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (474 aa)
	ATP5BL	ATP synthase subunit beta, mitochondrial. (362 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2. (482 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (320 aa)
	TSTA3	GDP-L-fucose synthase. (373 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAMP	TBXA2R	A0A151MCJ4	A0A151NCI8	Angio-associated migratory cell protein.	Thromboxane A2 receptor.	0.731
ACAA1	MAP2K5	A0A151PDL2	A0A151M8T8	3-ketoacyl-CoA thiolase, peroxisomal isoform B.	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.847
ACAA1	MAP3K3-2	A0A151PDL2	A0A151PC36	3-ketoacyl-CoA thiolase, peroxisomal isoform B.	Uncharacterized protein.	0.900
ACVR1	BMP10	A0A151MRU0	A0A151P5S6	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.988
ACVR1	BMPR2	A0A151MRU0	A0A151N9A5	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.978
ACVR1	GDF2	A0A151MRU0	A0A151ML35	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth/differentiation factor 2.	0.988
ACVR1	TGFB1	A0A151MRU0	A0A151P039	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	TGF_BETA_2 domain-containing protein.	0.787
ADAM17	TBXA2R	A0A151N827	A0A151NCI8	Disintegrin and metalloproteinase domain-containing protein 17.	Thromboxane A2 receptor.	0.470
AGT	ANXA1	A0A151M2N2	A0A151M8F4	Angiotensinogen; Belongs to the serpin family.	Annexin.	0.493
AGT	TGFB1	A0A151M2N2	A0A151P039	Angiotensinogen; Belongs to the serpin family.	TGF_BETA_2 domain-containing protein.	0.543
ANGPT2	EPHA2	A0A151NLG5	A0A151MJ88	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.657
ANGPT2	FLT1	A0A151NLG5	A0A151M7A2	Fibrinogen C-terminal domain-containing protein.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.912
ANGPT2	KDR	A0A151NLG5	A0A151PAF3	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.821
ANGPT2	MET-2	A0A151NLG5	A0A151PES3	Fibrinogen C-terminal domain-containing protein.	Uncharacterized protein.	0.679
ANGPT2	PDGFB	A0A151NLG5	A0A151NI26	Fibrinogen C-terminal domain-containing protein.	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.400
ANGPT2	TEK	A0A151NLG5	A0A151NEE9	Fibrinogen C-terminal domain-containing protein.	Angiopoietin-1 receptor.	0.990
ANGPT2	VEGFA-1	A0A151NLG5	A0A151MHH3	Fibrinogen C-terminal domain-containing protein.	Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family.	0.483
ANGPT2	VEGFC	A0A151NLG5	A0A151PB19	Fibrinogen C-terminal domain-containing protein.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.569
ANGPT2-1	EPHA2	A0A151P1H2	A0A151MJ88	Angiopoietin-2.	Uncharacterized protein.	0.657
ANGPT2-1	FLT1	A0A151P1H2	A0A151M7A2	Angiopoietin-2.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.825