(61 nodes) Positive regulation of endothelial cell migration network (Alligator mississippiensis)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	LGMN	Legumain. (470 aa)
	TSTA3	GDP-L-fucose synthase. (373 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2. (482 aa)
	ATP5BL	ATP synthase subunit beta, mitochondrial. (362 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (474 aa)
	NUS1	Dehydrodolichyl diphosphate syntase complex subunit NUS1. (177 aa)
	PLPP3	Lipid phosphate phosphohydrolase 3. (314 aa)
	PIK3CB-2	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
	EMC10	ER membrane protein complex subunit 10 isoform B. (283 aa)
	FGF1-1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FLT1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1725 aa)
	ANXA1	Annexin. (362 aa)
	IGF2-1	Insulin-like growth factor II isoform B. (217 aa)
	AAMP	Angio-associated migratory cell protein. (437 aa)
	VEGFA-1	Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
	ANXA3	Annexin. (323 aa)
	BCAR1	Breast cancer anti-estrogen resistance protein 1. (960 aa)
	THBS2	Thrombospondin-2. (1224 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (300 aa)
	Y1Q_0015232	UBA_6 domain-containing protein. (145 aa)
	Y1Q_0009788	Uncharacterized protein. (117 aa)
	ATP5A1	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (548 aa)
	CCBE1	Collagen and calcium-binding EGF domain-containing protein 1. (264 aa)
	ANGPT2-2	Angiopoietin-2. (498 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
	HSPB1	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (217 aa)
	Y1Q_0007194	Uncharacterized protein. (103 aa)
	BCAS3	Breast carcinoma-amplified sequence 3. (190 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1. (200 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
	FUT2	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (340 aa)
	CIB1	Calcium and integrin-binding protein 1. (190 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	RIN2	Ras and Rab interactor 2. (918 aa)
	TEK	Angiopoietin-1 receptor. (1114 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (814 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (389 aa)
	PDGFB	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
	Y1Q_0008439	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (375 aa)
	SASH1	SAM and SH3 domain-containing protein 1 isoform B. (1296 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (810 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (369 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (242 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	ANGPT2-1	Angiopoietin-2. (495 aa)
	SP1	Transcription factor Sp1. (746 aa)
	ATOH8	Atonal-like protein 8. (66 aa)
	KDR	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1353 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
	ATP5B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (493 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	MAP3K3-2	Uncharacterized protein. (657 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (925 aa)
	Y1Q_0014445	Junctional protein associated with coronary artery disease. (1337 aa)
	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal isoform B. (1024 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	MET-2	Uncharacterized protein. (1348 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA1	MAP3K3-2	A0A151PDL2	A0A151PC36	3-ketoacyl-CoA thiolase, peroxisomal isoform B.	Uncharacterized protein.	0.900
AGT	ANXA1	A0A151M2N2	A0A151M8F4	Angiotensinogen; Belongs to the serpin family.	Annexin.	0.493
AGT	TGFB1	A0A151M2N2	A0A151P039	Angiotensinogen; Belongs to the serpin family.	TGF_BETA_2 domain-containing protein.	0.543
ANGPT2-1	FLT1	A0A151P1H2	A0A151M7A2	Angiopoietin-2.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.825
ANGPT2-1	KDR	A0A151P1H2	A0A151PAF3	Angiopoietin-2.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.784
ANGPT2-1	MET-2	A0A151P1H2	A0A151PES3	Angiopoietin-2.	Uncharacterized protein.	0.671
ANGPT2-1	TEK	A0A151P1H2	A0A151NEE9	Angiopoietin-2.	Angiopoietin-1 receptor.	0.977
ANGPT2-2	FGF2	A0A151MXT8	A0A151PED4	Angiopoietin-2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.407
ANGPT2-2	FLT1	A0A151MXT8	A0A151M7A2	Angiopoietin-2.	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.809
ANGPT2-2	KDR	A0A151MXT8	A0A151PAF3	Angiopoietin-2.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.784
ANGPT2-2	MET-2	A0A151MXT8	A0A151PES3	Angiopoietin-2.	Uncharacterized protein.	0.671
ANGPT2-2	TEK	A0A151MXT8	A0A151NEE9	Angiopoietin-2.	Angiopoietin-1 receptor.	0.977
ANXA1	AGT	A0A151M8F4	A0A151M2N2	Annexin.	Angiotensinogen; Belongs to the serpin family.	0.493
ANXA1	ANXA3	A0A151M8F4	A0A151MPW6	Annexin.	Annexin.	0.464
ANXA3	ANXA1	A0A151MPW6	A0A151M8F4	Annexin.	Annexin.	0.464
ATP5A1	ATP5B	A0A151MWP5	A0A151PBG1	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.995
ATP5A1	ATP5BL	A0A151MWP5	A0A151M072	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit beta, mitochondrial.	0.992
ATP5A1	GPI	A0A151MWP5	A0A151N795	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.809
ATP5B	ATP5A1	A0A151PBG1	A0A151MWP5	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.995
ATP5B	ATP5BL	A0A151PBG1	A0A151M072	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit beta, mitochondrial.	0.900