(25 nodes) Regulation of tumor necrosis factor-mediated signaling pathway network (Alligator mississippiensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	Y1Q_0004030	Uncharacterized protein. (147 aa)
	NR1H4	Bile acid receptor. (453 aa)
	PARK2	E3 ubiquitin-protein ligase parkin isoform A. (280 aa)
	PARK2L	RBR-type E3 ubiquitin transferase. (180 aa)
	ADIPOQ	Adiponectin. (263 aa)
	SYK-2	Tyrosine-protein kinase. (608 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (412 aa)
	Y1Q_0006972	Uncharacterized protein. (555 aa)
	Y1Q_0010619	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (1690 aa)
	NKIRAS1	NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
	CYLD	Uncharacterized protein. (949 aa)
	Y1Q_0008457	Nucleolar protein 3-like. (196 aa)
	GPS2	Inner centromere protein. (286 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
	PYCARDL	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (429 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (699 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (541 aa)
	GAS6	Growth arrest-specific protein 6. (676 aa)
	BIRC7-1	Baculoviral IAP repeat-containing protein 7 isoform A. (309 aa)
	OTULIN	Ubiquitin thioesterase otulin isoform B. (480 aa)
	CYLDL	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
	NAIP	Baculoviral IAP repeat-containing protein 1 isoform A. (878 aa)
	UBE2K	Ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	NKIRAS2	NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC7-1	CYLD	A0A151NYK9	A0A151MS02	Baculoviral IAP repeat-containing protein 7 isoform A.	Uncharacterized protein.	0.424
BIRC7-1	CYLDL	A0A151NYK9	A0A151P8D8	Baculoviral IAP repeat-containing protein 7 isoform A.	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	0.424
BIRC7-1	RIPK1	A0A151NYK9	A0A151NFC5	Baculoviral IAP repeat-containing protein 7 isoform A.	Receptor-interacting serine/threonine-protein kinase 1.	0.683
BIRC7-1	TNFRSF1A	A0A151NYK9	A0A151MD86	Baculoviral IAP repeat-containing protein 7 isoform A.	Tumor necrosis factor receptor superfamily member 1A.	0.749
CYLD	BIRC7-1	A0A151MS02	A0A151NYK9	Uncharacterized protein.	Baculoviral IAP repeat-containing protein 7 isoform A.	0.424
CYLD	CYLDL	A0A151MS02	A0A151P8D8	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	0.903
CYLD	NAIP	A0A151MS02	A0A151PIA8	Uncharacterized protein.	Baculoviral IAP repeat-containing protein 1 isoform A.	0.424
CYLD	OTULIN	A0A151MS02	A0A151P1P8	Uncharacterized protein.	Ubiquitin thioesterase otulin isoform B.	0.627
CYLD	RIPK1	A0A151MS02	A0A151NFC5	Uncharacterized protein.	Receptor-interacting serine/threonine-protein kinase 1.	0.983
CYLD	TNFRSF1A	A0A151MS02	A0A151MD86	Uncharacterized protein.	Tumor necrosis factor receptor superfamily member 1A.	0.931
CYLD	Y1Q_0004030	A0A151MS02	A0A151PHN1	Uncharacterized protein.	Uncharacterized protein.	0.424
CYLD	Y1Q_0010619	A0A151MS02	A0A151PH67	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.903
CYLDL	BIRC7-1	A0A151P8D8	A0A151NYK9	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Baculoviral IAP repeat-containing protein 7 isoform A.	0.424
CYLDL	CYLD	A0A151P8D8	A0A151MS02	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.903
CYLDL	NAIP	A0A151P8D8	A0A151PIA8	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Baculoviral IAP repeat-containing protein 1 isoform A.	0.424
CYLDL	RIPK1	A0A151P8D8	A0A151NFC5	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Receptor-interacting serine/threonine-protein kinase 1.	0.983
CYLDL	TNFRSF1A	A0A151P8D8	A0A151MD86	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor superfamily member 1A.	0.916
CYLDL	Y1Q_0004030	A0A151P8D8	A0A151PHN1	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.424
CYLDL	Y1Q_0010619	A0A151P8D8	A0A151PH67	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.903
NAIP	CYLD	A0A151PIA8	A0A151MS02	Baculoviral IAP repeat-containing protein 1 isoform A.	Uncharacterized protein.	0.424