STRINGSTRING
PDK4 PDK4 FAM3C FAM3C DHX58 DHX58 IGFBP4 IGFBP4 NKX1-1 NKX1-1 Y1Q_0015122 Y1Q_0015122 PPARAB PPARAB PDK2 PDK2 TIGAR TIGAR SIRT1 SIRT1 DDB1 DDB1 SIRT6 SIRT6 RANBP2 RANBP2 SOGA1 SOGA1 LCMT1 LCMT1 FOXK2 FOXK2 OGT OGT SLC35B4 SLC35B4 MLYCD MLYCD LEPR-1 LEPR-1 ACADM ACADM CRY1 CRY1 Y1Q_0024039 Y1Q_0024039 C1QTNF6-1 C1QTNF6-1 CREBBP CREBBP SESN2L SESN2L PTPN2 PTPN2 GPLD1 GPLD1 DGKQ DGKQ FAM132A FAM132A GTF2IRD2 GTF2IRD2 COX11 COX11 FOXK1 FOXK1 USP7 USP7 PDK3-2 PDK3-2 MIDN MIDN DUSP12 DUSP12 TP53 TP53 MST1 MST1 BCKDK BCKDK MIDNL MIDNL KAT2B KAT2B LEP LEP GNMT GNMT IGF2-1 IGF2-1 PTH PTH SLC45A3 SLC45A3 RORA RORA ADIPOQ ADIPOQ RORC RORC PARK2L PARK2L PARK2 PARK2 PDK3 PDK3 FAM3A FAM3A SIRT7 SIRT7 Y1Q_0022355 Y1Q_0022355 ZNF692-1 ZNF692-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDK4Protein-serine/threonine kinase. (414 aa)
FAM3CProtein FAM3C. (227 aa)
DHX58Putative ATP-dependent RNA helicase DHX58 isoform E; Belongs to the small heat shock protein (HSP20) family. (1743 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (242 aa)
NKX1-1Homeobox protein SAX-1. (386 aa)
Y1Q_0015122Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (246 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
PDK2Protein-serine/threonine kinase. (408 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (272 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
RANBP2E3 SUMO-protein ligase RanBP2. (2133 aa)
SOGA1Protein SOGA1 isoform A. (1537 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (329 aa)
FOXK2Forkhead box protein K2. (562 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit isoform B. (1075 aa)
SLC35B4UDP-xylose and UDP-N-acetylglucosamine transporter. (341 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (591 aa)
LEPR-1Leptin receptor isoform B. (528 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (486 aa)
CRY1Cryptochrome 4. (665 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
C1QTNF6-1Complement C1q tumor necrosis factor-related protein 6 isoform A. (243 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
SESN2LSestrin 2. (509 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (429 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (814 aa)
DGKQDiacylglycerol kinase. (973 aa)
FAM132AAdipolin. (569 aa)
GTF2IRD2General transcription factor II-I repeat domain-containing protein 2A isoform A. (496 aa)
COX11Cytochrome c oxidase assembly protein COX11, mitochondrial. (171 aa)
FOXK1Forkhead box protein K1. (598 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1080 aa)
PDK3-2Protein-serine/threonine kinase. (406 aa)
MIDNMidnolin. (80 aa)
DUSP12Dual specificity protein phosphatase 12. (210 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
BCKDKProtein-serine/threonine kinase. (379 aa)
MIDNLMidnolin. (361 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (783 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (168 aa)
GNMTGlycine N-methyltransferase. (294 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
PTHParathyroid hormone. (126 aa)
SLC45A3Solute carrier family 45 member 3. (662 aa)
RORANuclear receptor ROR-alpha isoform B. (468 aa)
ADIPOQAdiponectin. (263 aa)
RORCNuclear receptor ROR-gamma. (521 aa)
PARK2LRBR-type E3 ubiquitin transferase. (180 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform A. (280 aa)
PDK3Protein-serine/threonine kinase. (432 aa)
FAM3AProtein FAM3A. (232 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (403 aa)
Y1Q_0022355General transcription factor II-I repeat domain-containing protein 2B-like. (502 aa)
ZNF692-1Zinc finger protein 692 isoform C. (659 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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