STRINGSTRING
CYR61 CYR61 WDTC1 WDTC1 DKKL1 DKKL1 FGF21 FGF21 PIBF1 PIBF1 MLYCD MLYCD ARMC5-2 ARMC5-2 Y1Q_0011870 Y1Q_0011870 Y1Q_0015586 Y1Q_0015586 ABCD2 ABCD2 CCDC3 CCDC3 SORL1 SORL1 ABCG1-2 ABCG1-2 TNF TNF ENPP7 ENPP7 Y1Q_0006678 Y1Q_0006678 Y1Q_0006677 Y1Q_0006677 PLPP6-2 PLPP6-2 Y1Q_0006679 Y1Q_0006679 FMO5 FMO5 FMO1 FMO1 MTMR4 MTMR4 MID1IP1 MID1IP1 NR0B1 NR0B1 SLC27A1 SLC27A1 TRIB3 TRIB3 EIF6 EIF6 ACER1 ACER1 SIRT6 SIRT6 PNPLA2 PNPLA2 PPARD PPARD CTDNEP1-1 CTDNEP1-1 SIRT3-1 SIRT3-1 SNAI1 SNAI1 PSAP-2 PSAP-2 TGFB1 TGFB1 SIRT1 SIRT1 TYSND1 TYSND1 Y1Q_0016095 Y1Q_0016095 PSAP-1 PSAP-1 TTC39B TTC39B MTM1 MTM1 PIK3R4 PIK3R4 LPGAT1 LPGAT1 SREBF1 SREBF1 EPHX2 EPHX2 ORMDL3 ORMDL3 Y1Q_0004713 Y1Q_0004713 PIP4K2B PIP4K2B PDK2 PDK2 APOBEC1A APOBEC1A PPARAB PPARAB CREBL2 CREBL2 APOD APOD Y1Q_0015104 Y1Q_0015104 Y1Q_0015122 Y1Q_0015122 FGFR3 FGFR3 ASAH1 ASAH1 BRCA1 BRCA1 NR1D1 NR1D1 PIP4K2A PIP4K2A ANKRD26 ANKRD26 CAV1 CAV1 IFNG IFNG Y1Q_0019040 Y1Q_0019040 PIP4K2C PIP4K2C STOML2 STOML2 ERLIN1 ERLIN1 SNAPC2L SNAPC2L ADGRF5 ADGRF5 STARD4 STARD4 APOB APOB PPARG PPARG LAMTOR1 LAMTOR1 Y1Q_0007599 Y1Q_0007599 RARRES2 RARRES2 FMC1 FMC1 NR1H4 NR1H4 FAM3A FAM3A APOA5 APOA5 APOA4 APOA4 PDK3 PDK3 ATG14 ATG14 ARV1 ARV1 TTC39A-2 TTC39A-2 SCP2 SCP2 ARMC5-1 ARMC5-1 TMC4 TMC4 RORC RORC ADIPOQ ADIPOQ DNAJC19 DNAJC19 FGF1-1 FGF1-1 H2AFY H2AFY CD74 CD74 PDGFRA PDGFRA GOLM1-1 GOLM1-1 ANXA1 ANXA1 TNFAIP8L3 TNFAIP8L3 LACTB-1 LACTB-1 RORA RORA SLC45A3 SLC45A3 NR1H3 NR1H3 AMBRA1 AMBRA1 PRMT3 PRMT3 FGF19 FGF19 DKK3 DKK3 IGF2-1 IGF2-1 LRRN4CL LRRN4CL Y1Q_0002897 Y1Q_0002897 LPCAT3 LPCAT3 ZBTB20 ZBTB20 SPHK2 SPHK2 Y1Q_0004590 Y1Q_0004590 HTR2A HTR2A DNAJC15 DNAJC15 PTGS2 PTGS2 FMO3 FMO3 FMO2 FMO2 CAV3 CAV3 IL1BL IL1BL MFSD2A MFSD2A Y1Q_0001844 Y1Q_0001844 MTMR9 MTMR9 TTC39A TTC39A FABP5 FABP5 SNAI2 SNAI2 LYN LYN CYP7A1 CYP7A1 LEP LEP REST REST PDK4 PDK4 NR1D2 NR1D2 ABHD5 ABHD5 LONP2 LONP2 CNEP1R1 CNEP1R1 FLT1-2 FLT1-2 SAMD8 SAMD8 DDX20 DDX20 Y1Q_0014200 Y1Q_0014200 MTMR9-2 MTMR9-2 PRKAA1-2 PRKAA1-2 ABCD1-2 ABCD1-2 ABHD6 ABHD6 RUBCN RUBCN EPHA8 EPHA8 WNT4 WNT4 OPA3 OPA3 PDK3-2 PDK3-2 GPS2 GPS2 DAGLB DAGLB Y1Q_0016328 Y1Q_0016328 FGFR4 FGFR4 SPHK1 SPHK1 PTCHD2 PTCHD2 MTOR MTOR H6PD H6PD PIK3IP1 PIK3IP1 SEC14L2 SEC14L2 SIRT4 SIRT4 THRSP THRSP MTMR3 MTMR3 SEC14L5 SEC14L5 PNPLA3 PNPLA3 LPIN1 LPIN1 MTMR1 MTMR1 CCL21 CCL21 MLXIPL MLXIPL SCAP SCAP IDH1-2 IDH1-2 CREB1 CREB1 ORMDL1 ORMDL1 NR1D4A NR1D4A ACSL3-2 ACSL3-2 ERLIN2 ERLIN2 STAR STAR ABCD1 ABCD1 BSCL2 BSCL2 BMP7 BMP7 LPCAT1 LPCAT1 DGKQ DGKQ ORMDL2 ORMDL2 TEK TEK GPLD1 GPLD1 SF1 SF1 ABCG1 ABCG1 SREBF2 SREBF2 PLA2G6 PLA2G6 PDGFB PDGFB APPL2 APPL2 METTL20 METTL20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYR61Protein CYR61. (374 aa)
WDTC1WD and tetratricopeptide repeats protein 1. (664 aa)
DKKL1Dickkopf-like protein 1. (368 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform B. (756 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (591 aa)
ARMC5-2Armadillo repeat-containing protein 5. (207 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
Y1Q_0015586Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
ABCD2ATP-binding cassette sub-family D member 2. (424 aa)
CCDC3Coiled-coil domain-containing protein 3. (274 aa)
SORL1Sortilin-related receptor isoform B. (2170 aa)
ABCG1-2ABC transporter domain-containing protein. (666 aa)
TNFTumor necrosis factor. (231 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase family member 7. (397 aa)
Y1Q_0006678Flavin-containing monooxygenase. (126 aa)
Y1Q_0006677Flavin-containing monooxygenase. (132 aa)
PLPP6-2Flavin-containing monooxygenase. (479 aa)
Y1Q_0006679Flavin-containing monooxygenase. (446 aa)
FMO5Flavin-containing monooxygenase. (464 aa)
FMO1Flavin-containing monooxygenase. (636 aa)
MTMR4Myotubularin-related protein 4 isoform A. (1123 aa)
MID1IP1Mid1-interacting protein 1. (173 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (130 aa)
SLC27A1Long-chain fatty acid transport protein 1. (743 aa)
TRIB3Tribbles-like protein 3. (340 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (318 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2. (483 aa)
PPARDUncharacterized protein. (442 aa)
CTDNEP1-1CTD nuclear envelope phosphatase 1 isoform B. (243 aa)
SIRT3-1NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
SNAI1Zinc finger protein SNAI1. (420 aa)
PSAP-2Prosaposin. (529 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
TYSND1Serine protease; Belongs to the peptidase S1B family. (373 aa)
Y1Q_0016095Uncharacterized protein. (133 aa)
PSAP-1Prosaposin isoform B. (529 aa)
TTC39BUncharacterized protein. (427 aa)
MTM1Myotubularin isoform B. (650 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1397 aa)
LPGAT1Acyl-CoA:lysophosphatidylglycerol acyltransferase 1. (337 aa)
SREBF1BHLH domain-containing protein. (1085 aa)
EPHX2Bifunctional epoxide hydrolase 2. (557 aa)
ORMDL3ORM1-like protein 3. (235 aa)
Y1Q_0004713C-C motif chemokine 19-like. (72 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (411 aa)
PDK2Protein-serine/threonine kinase. (408 aa)
APOBEC1AC->U-editing enzyme APOBEC-1. (198 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform B. (139 aa)
APODApolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (339 aa)
Y1Q_0015104Uncharacterized protein. (150 aa)
Y1Q_0015122Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (246 aa)
FGFR3Fibroblast growth factor receptor. (837 aa)
ASAH1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (555 aa)
PIP4K2APIPK domain-containing protein. (405 aa)
ANKRD26Ankyrin repeat domain-containing protein 26 isoform A. (824 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
Y1Q_0019040Uncharacterized protein. (84 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (458 aa)
STOML2Stomatin-like protein 2, mitochondrial. (326 aa)
ERLIN1Erlin-1. (335 aa)
SNAPC2LDimethylaniline monooxygenase [N-oxide-forming]. (550 aa)
ADGRF5Adhesion G protein-coupled receptor F5 isoform A; Belongs to the G-protein coupled receptor 2 family. (1294 aa)
STARD4StAR-related lipid transfer protein 4. (233 aa)
APOBApolipoprotein B-100. (4482 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)
LAMTOR1Ragulator complex protein LAMTOR1. (161 aa)
Y1Q_0007599Uncharacterized protein. (420 aa)
RARRES2Retinoic acid receptor responder protein 2. (156 aa)
FMC1Uncharacterized protein. (113 aa)
NR1H4Bile acid receptor. (453 aa)
FAM3AProtein FAM3A. (232 aa)
APOA5Apolipoprotein A-V. (395 aa)
APOA4Apolipoprotein A-IV. (323 aa)
PDK3Protein-serine/threonine kinase. (432 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (497 aa)
ARV1Protein ARV1. (237 aa)
TTC39A-2Uncharacterized protein. (575 aa)
SCP2Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (541 aa)
ARMC5-1Armadillo repeat-containing protein 5. (628 aa)
TMC4Transmembrane channel-like protein; Belongs to the membrane-bound acyltransferase family. (1083 aa)
RORCNuclear receptor ROR-gamma. (521 aa)
ADIPOQAdiponectin. (263 aa)
DNAJC19Mitochondrial import inner membrane translocase subunit TIM14. (114 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
H2AFYCore histone macro-H2A.1 isoform C; Belongs to the histone H2A family. (435 aa)
CD74HLA class II histocompatibility antigen gamma chain; Belongs to the universal ribosomal protein uS11 family. (513 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1097 aa)
GOLM1-1Golgi membrane protein 1 isoform B. (456 aa)
ANXA1Annexin. (362 aa)
TNFAIP8L3Tumor necrosis factor alpha-induced protein 8-like protein 3. (255 aa)
LACTB-1Serine beta-lactamase-like protein LACTB, mitochondrial isoform B. (467 aa)
RORANuclear receptor ROR-alpha isoform B. (468 aa)
SLC45A3Solute carrier family 45 member 3. (662 aa)
NR1H3Oxysterols receptor LXR-alpha. (408 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform A. (1224 aa)
PRMT3Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (517 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
DKK3Dickkopf-related protein 3. (312 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
LRRN4CLLRRN4 C-terminal-like protein. (261 aa)
Y1Q_0002897Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (474 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20. (769 aa)
SPHK2Sphingosine kinase 2. (591 aa)
Y1Q_0004590DUF4206 domain-containing protein. (677 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
DNAJC15DnaJ-like protein subfamily C member 15. (145 aa)
PTGS2Prostaglandin G/H synthase 2. (605 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
FMO2Flavin-containing monooxygenase. (431 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
IL1BLInterleukin-1. (280 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1 isoform A. (503 aa)
Y1Q_0001844Interleukin-1. (129 aa)
MTMR9Myotubularin-related protein 9 isoform A. (530 aa)
TTC39ATetratricopeptide repeat protein 39A. (564 aa)
FABP5Fatty acid binding protein 5 (Psoriasis-associated); Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
LYNTyrosine-protein kinase. (562 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (278 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (168 aa)
RESTRE1-silencing transcription factor. (913 aa)
PDK4Protein-serine/threonine kinase. (414 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform B. (589 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5. (342 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-. (873 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1. (125 aa)
FLT1-2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
SAMD8Sphingomyelin synthase-related protein 1. (232 aa)
DDX20Putative ATP-dependent RNA helicase DDX20; Belongs to the DEAD box helicase family. (475 aa)
Y1Q_0014200Nuclear receptor subfamily 0 group B member 2-like. (369 aa)
MTMR9-2Myotubularin phosphatase domain-containing protein. (550 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
ABCD1-2ABC transporter domain-containing protein. (250 aa)
ABHD6Monoacylglycerol lipase ABHD6. (330 aa)
RUBCNRun domain Beclin-1 interacting and cysteine-rich containing protein isoform A. (1001 aa)
EPHA8Uncharacterized protein. (969 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
OPA3Optic atrophy 3 protein. (156 aa)
PDK3-2Protein-serine/threonine kinase. (406 aa)
GPS2Inner centromere protein. (286 aa)
DAGLBSn1-specific diacylglycerol lipase beta. (674 aa)
Y1Q_0016328Uncharacterized protein. (224 aa)
FGFR4Uncharacterized protein. (518 aa)
SPHK1Sphingosine kinase 1. (537 aa)
PTCHD2Patched domain-containing protein 2 isoform A. (1339 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein. (715 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1. (262 aa)
SEC14L2SEC14-like protein 2. (409 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial. (305 aa)
THRSPThyroid hormone responsive. (131 aa)
MTMR3Uncharacterized protein. (1166 aa)
SEC14L5Uncharacterized protein. (755 aa)
PNPLA3Patatin-like phospholipase domain-containing protein 2 isoform B. (530 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform B. (975 aa)
MTMR1Uncharacterized protein. (655 aa)
CCL21SCY domain-containing protein. (93 aa)
MLXIPLCarbohydrate-responsive element-binding protein. (711 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1313 aa)
IDH1-2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (435 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (163 aa)
NR1D4ANuclear receptor subfamily 1, group D, member 4a. (431 aa)
ACSL3-2AMP-binding domain-containing protein. (663 aa)
ERLIN2Erlin-2. (364 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (287 aa)
ABCD1ATP-binding cassette sub-family D member 1. (387 aa)
BSCL2Seipin. (353 aa)
BMP7Bone morphogenetic protein 7. (416 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (512 aa)
DGKQDiacylglycerol kinase. (973 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
TEKAngiopoietin-1 receptor. (1114 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (814 aa)
SF1Splicing factor 1 isoform B. (668 aa)
ABCG1ATP-binding cassette sub-family G member 1. (861 aa)
SREBF2Sterol regulatory element-binding protein 2 isoform A. (1079 aa)
PLA2G685/calcium-independent phospholipase A2. (840 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
APPL2Uncharacterized protein. (659 aa)
METTL20Protein N-lysine methyltransferase METTL20. (241 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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