(14 nodes) Desmosome network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DSG2	Desmoglein-2. (1142 aa)
	DSC2	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (893 aa)
	KAZN	Kazrin isoform B. (641 aa)
	KLHL24	Kelch-like protein 24. (595 aa)
	JUP	Uncharacterized protein. (718 aa)
	PKP3	Plakophilin-3. (833 aa)
	KLHL6	Kelch-like protein 6. (585 aa)
	KLHL24-2	Uncharacterized protein. (303 aa)
	JAM3	Junctional adhesion molecule C. (319 aa)
	POF1B	Protein POF1B. (489 aa)
	PKP2	Plakophilin-2. (822 aa)
	PKP1	Plakophilin-1 isoform A. (731 aa)
	VCL	Vinculin. (1066 aa)
	DSG1	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1032 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DSC2	DSG1	A0A151MNS6	A0A151MP57	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.753
DSC2	DSG2	A0A151MNS6	A0A151MP26	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmoglein-2.	0.767
DSC2	JUP	A0A151MNS6	A0A151PC76	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.877
DSC2	PKP1	A0A151MNS6	A0A151N8P7	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-1 isoform A.	0.852
DSC2	PKP2	A0A151MNS6	A0A151NIR6	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-2.	0.916
DSC2	PKP3	A0A151MNS6	A0A151NXJ0	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-3.	0.747
DSG1	DSC2	A0A151MP57	A0A151MNS6	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.753
DSG1	JUP	A0A151MP57	A0A151PC76	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Uncharacterized protein.	0.736
DSG1	PKP1	A0A151MP57	A0A151N8P7	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-1 isoform A.	0.819
DSG1	PKP2	A0A151MP57	A0A151NIR6	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-2.	0.719
DSG1	PKP3	A0A151MP57	A0A151NXJ0	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	Plakophilin-3.	0.654
DSG2	DSC2	A0A151MP26	A0A151MNS6	Desmoglein-2.	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.767
DSG2	JUP	A0A151MP26	A0A151PC76	Desmoglein-2.	Uncharacterized protein.	0.736
DSG2	PKP1	A0A151MP26	A0A151N8P7	Desmoglein-2.	Plakophilin-1 isoform A.	0.780
DSG2	PKP2	A0A151MP26	A0A151NIR6	Desmoglein-2.	Plakophilin-2.	0.814
DSG2	PKP3	A0A151MP26	A0A151NXJ0	Desmoglein-2.	Plakophilin-3.	0.654
JUP	DSC2	A0A151PC76	A0A151MNS6	Uncharacterized protein.	Desmocollin-2 isoform A; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.877
JUP	DSG1	A0A151PC76	A0A151MP57	Uncharacterized protein.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	0.736
JUP	DSG2	A0A151PC76	A0A151MP26	Uncharacterized protein.	Desmoglein-2.	0.736
JUP	PKP1	A0A151PC76	A0A151N8P7	Uncharacterized protein.	Plakophilin-1 isoform A.	0.835