(76 nodes) Glycosaminoglycan metabolic process network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHSY1	Hexosyltransferase. (520 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (320 aa)
	TNFAIP6	Tumor necrosis factor-inducible 6 protein. (275 aa)
	HS3ST4	Sulfotransferase; Belongs to the sulfotransferase 1 family. (209 aa)
	DSE	Dermatan-sulfate epimerase. (934 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (352 aa)
	NDST1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2. (899 aa)
	ITIH6-1	Inter-alpha-trypsin inhibitor heavy chain H6 isoform B. (888 aa)
	CHSY3	Chondroitin sulfate synthase 3. (209 aa)
	MAMDC2	MAM domain-containing protein 2. (684 aa)
	TMEM2	Transmembrane protein 2. (1374 aa)
	CLN6	Ceroid-lipofuscinosis neuronal protein 6. (339 aa)
	GLCE	D-glucuronyl C5-epimerase. (751 aa)
	CHSY1-2	Hexosyltransferase. (530 aa)
	CHST1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (419 aa)
	EXT2	Exostosin-2; Belongs to the glycosyltransferase 47 family. (701 aa)
	B4GALT4	Beta-1,4-galactosyltransferase 4. (361 aa)
	HYAL1	Hyaluronidase. (445 aa)
	HYAL2	Hyaluronidase. (474 aa)
	HYAL3-1	Hyaluronidase. (644 aa)
	CSGALNACT1	Hexosyltransferase. (531 aa)
	CHST13	Carbohydrate sulfotransferase. (340 aa)
	HEXB	Beta-hexosaminidase. (531 aa)
	IL1BL	Interleukin-1. (280 aa)
	Y1Q_0001844	Interleukin-1. (129 aa)
	IMPAD1	Inositol monophosphatase 3. (242 aa)
	Y1Q_0017194	Protein NDNF-like. (560 aa)
	NDST2	Uncharacterized protein. (879 aa)
	CSGALNACT2	Hexosyltransferase. (473 aa)
	CHST14	Carbohydrate sulfotransferase. (163 aa)
	EGFLAM	Pikachurin. (936 aa)
	HAS2-2	Uncharacterized protein. (482 aa)
	B3GAT3	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (321 aa)
	XYLT1	Uncharacterized protein. (872 aa)
	CHST12	Carbohydrate sulfotransferase. (419 aa)
	HS3ST6	Sulfotransferase; Belongs to the sulfotransferase 1 family. (203 aa)
	XYLT2	Xylosyltransferase 2. (748 aa)
	B3GALT6	Hexosyltransferase. (294 aa)
	IDS	Iduronate 2-sulfatase. (545 aa)
	CHPF	Hexosyltransferase. (676 aa)
	PXYLP1	2-phosphoxylose phosphatase 1; Belongs to the histidine acid phosphatase family. (254 aa)
	Y1Q_0010494	Bifunctional protein GlmU-like. (145 aa)
	Y1Q_0000948	Uncharacterized protein. (96 aa)
	IDUA	Alpha-L-iduronidase. (549 aa)
	DSEL	Uncharacterized protein. (150 aa)
	CHST11	Carbohydrate sulfotransferase. (402 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	SGSH	N-sulfoglucosamine sulfohydrolase. (415 aa)
	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2 isoform A. (1001 aa)
	ITIH5	Inter-alpha-trypsin inhibitor heavy chain H5. (951 aa)
	UGDH	UDP-glucose 6-dehydrogenase. (305 aa)
	HAS1	Uncharacterized protein. (736 aa)
	HS3ST2	Sulfotransferase; Belongs to the sulfotransferase 1 family. (174 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7. (213 aa)
	CHST7	Carbohydrate sulfotransferase 7. (342 aa)
	HAS2	Hyaluronan synthase 2. (548 aa)
	TGFB1	TGF_BETA_2 domain-containing protein. (242 aa)
	SPOCK2	Testican-2. (360 aa)
	CHST3	Sulfotransferase; Belongs to the sulfotransferase 1 family. (494 aa)
	HPSE	Heparanase. (529 aa)
	Y1Q_0007371	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	UGDH-2	UDPG_MGDP_dh_N domain-containing protein. (102 aa)
	SLC10A7	Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (403 aa)
	EDNRA	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	NDST3	Uncharacterized protein. (811 aa)
	Y1Q_0001241	Uncharacterized protein. (891 aa)
	CHPF2	Hexosyltransferase. (577 aa)
	HYAL6	Hyaluronidase. (454 aa)
	NDNF	Protein NDNF. (578 aa)
	HYAL4	Hyaluronidase. (507 aa)
	SPAM1-1	Hyaluronidase. (464 aa)
	GNS	N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (531 aa)
	PGLYRP2	N-acetylmuramoyl-L-alanine amidase. (594 aa)
	HEXB-2	Uncharacterized protein. (441 aa)
	ARSK	Arylsulfatase K isoform B. (441 aa)
	PGLYRP3	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (186 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSK	HEXB-2	A0A151PI63	A0A151PHJ1	Arylsulfatase K isoform B.	Uncharacterized protein.	0.498
ARSK	SGSH	A0A151PI63	A0A151NLH1	Arylsulfatase K isoform B.	N-sulfoglucosamine sulfohydrolase.	0.420
B3GALT6	B3GAT3	A0A151N4M8	A0A151N0T3	Hexosyltransferase.	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	0.544
B3GALT6	B4GALT7	A0A151N4M8	A0A151NVP0	Hexosyltransferase.	Beta-1,4-galactosyltransferase 7.	0.723
B3GALT6	CSGALNACT1	A0A151N4M8	A0A151MIW2	Hexosyltransferase.	Hexosyltransferase.	0.716
B3GALT6	CSGALNACT2	A0A151N4M8	A0A151MT42	Hexosyltransferase.	Hexosyltransferase.	0.581
B3GALT6	DCN	A0A151N4M8	A0A151LYQ7	Hexosyltransferase.	Decorin; May affect the rate of fibrils formation.	0.499
B3GALT6	DSE	A0A151N4M8	A0A151M2Y8	Hexosyltransferase.	Dermatan-sulfate epimerase.	0.543
B3GALT6	EXT2	A0A151N4M8	A0A151MBF7	Hexosyltransferase.	Exostosin-2; Belongs to the glycosyltransferase 47 family.	0.402
B3GALT6	XYLT1	A0A151N4M8	A0A151N191	Hexosyltransferase.	Uncharacterized protein.	0.483
B3GALT6	XYLT2	A0A151N4M8	A0A151N2U5	Hexosyltransferase.	Xylosyltransferase 2.	0.483
B3GAT3	B3GALT6	A0A151N0T3	A0A151N4M8	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Hexosyltransferase.	0.544
B3GAT3	B4GALT7	A0A151N0T3	A0A151NVP0	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Beta-1,4-galactosyltransferase 7.	0.562
B3GAT3	CSGALNACT1	A0A151N0T3	A0A151MIW2	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Hexosyltransferase.	0.946
B3GAT3	CSGALNACT2	A0A151N0T3	A0A151MT42	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Hexosyltransferase.	0.940
B3GAT3	DCN	A0A151N0T3	A0A151LYQ7	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Decorin; May affect the rate of fibrils formation.	0.455
B3GAT3	EXT2	A0A151N0T3	A0A151MBF7	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Exostosin-2; Belongs to the glycosyltransferase 47 family.	0.412
B3GAT3	GLCE	A0A151N0T3	A0A151M8U9	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	D-glucuronyl C5-epimerase.	0.433
B3GAT3	HS2ST1	A0A151N0T3	A0A151M555	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Heparan sulfate 2-O-sulfotransferase 1.	0.451
B4GALT7	B3GALT6	A0A151NVP0	A0A151N4M8	Beta-1,4-galactosyltransferase 7.	Hexosyltransferase.	0.723