STRINGSTRING
PTEN PTEN DGKA-2 DGKA-2 CERKL CERKL HAO2-1 HAO2-1 SGPP1 SGPP1 SYNJ2 SYNJ2 ACAT2 ACAT2 ECHDC1-1 ECHDC1-1 PEX7 PEX7 TMEM55B TMEM55B HSD17B10 HSD17B10 SCP2 SCP2 SPATA9 SPATA9 ECHDC2 ECHDC2 PLPP3 PLPP3 CPT1A CPT1A TMC4 TMC4 PLPPR4 PLPPR4 PLPPR5 PLPPR5 Y1Q_0007485 Y1Q_0007485 ABCD3 ABCD3 ADIPOQ ADIPOQ HSD17B4 HSD17B4 AUH AUH ETFA ETFA MTMR10 MTMR10 DGKZ DGKZ SLC35C1 SLC35C1 LPCAT3 LPCAT3 PEX5 PEX5 SYNJ1 SYNJ1 CRAT-2 CRAT-2 CCDC180 CCDC180 INPP5E INPP5E PEX13 PEX13 SPHK2 SPHK2 HAO1 HAO1 HADH HADH FIG4 FIG4 Y1Q_0023826 Y1Q_0023826 ACOX2 ACOX2 INPP5K INPP5K GCDH GCDH Y1Q_0001159 Y1Q_0001159 MTMR9 MTMR9 LEP LEP CROT CROT Y1Q_0019151 Y1Q_0019151 DGKB DGKB HACL1 HACL1 HADHA HADHA HADHB HADHB GBA2 GBA2 MTMR6 MTMR6 FA2H FA2H ECHS1 ECHS1 MTMR9-2 MTMR9-2 ETFB ETFB ACAA2 ACAA2 MTMR12 MTMR12 PRKAA1-2 PRKAA1-2 PLPP1 PLPP1 LCAT LCAT ABCD1-2 ABCD1-2 CPT1C CPT1C CARTPT CARTPT TMEM130 TMEM130 CCDC115 CCDC115 DGKE DGKE SPHK1 SPHK1 ACOX1 ACOX1 CYGB CYGB B4GALNT1 B4GALNT1 ACADS ACADS MTMR3 MTMR3 MTM1-2 MTM1-2 MTMR1 MTMR1 ADIPOR2L ADIPOR2L MBOAT2 MBOAT2 GBA GBA SGPP2 SGPP2 PLPP5 PLPP5 TPTE2 TPTE2 ABCD1 ABCD1 PORCN-1 PORCN-1 INPP5J INPP5J DGKQ DGKQ PLPPR1 PLPPR1 MBOAT1 MBOAT1 Y1Q_0008065 Y1Q_0008065 ECI2 ECI2 OCRL OCRL ST3GAL4-1 ST3GAL4-1 Y1Q_0003577 Y1Q_0003577 SESN2L SESN2L ECI1 ECI1 Y1Q_0020688 Y1Q_0020688 SMIM24 SMIM24 Y1Q_0011971 Y1Q_0011971 DGKA DGKA EHHADH EHHADH SLC25A17 SLC25A17 Y1Q_0024247 Y1Q_0024247 AGK AGK DGKI DGKI ADIPOR2 ADIPOR2 ACADM ACADM ABCD4 ABCD4 SAMD1 SAMD1 Y1Q_0015775 Y1Q_0015775 MLYCD MLYCD BDH2 BDH2 MTMR8 MTMR8 Y1Q_0015641 Y1Q_0015641 ABCD2 ABCD2 CERK CERK PHYH PHYH ACAD10-2 ACAD10-2 MTMR11 MTMR11 MTMR4 MTMR4 PLPP6 PLPP6 INPP5F INPP5F PLPP4 PLPP4 INPP5D-2 INPP5D-2 ILVBL ILVBL Y1Q_0002522 Y1Q_0002522 CPT1A-2 CPT1A-2 PPARD PPARD PLPPR3 PLPPR3 PPAP2C PPAP2C INPP5A INPP5A MTM1 MTM1 Y1Q_0016093 Y1Q_0016093 ACAD10 ACAD10 EPHX2 EPHX2 PLPPR2-1 PLPPR2-1 ACAT1 ACAT1 OCRL-2 OCRL-2 ACOX3 ACOX3 Y1Q_0021372 Y1Q_0021372 Y1Q_0021662 Y1Q_0021662 CYP4V2 CYP4V2 ETFDH ETFDH MTMR7 MTMR7 TMEM55A-1 TMEM55A-1 DECR1 DECR1 Y1Q_0004104 Y1Q_0004104 CRAT CRAT INPP5D INPP5D ECH1 ECH1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DGKA-2Diacylglycerol kinase. (742 aa)
CERKLCeramide kinase-like protein isoform A. (526 aa)
HAO2-1Hydroxyacid oxidase 2 isoform B. (576 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (262 aa)
SYNJ2Uncharacterized protein. (1514 aa)
ACAT2Acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ECHDC1-1Ethylmalonyl-CoA decarboxylase isoform A; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
PEX7Peroxisomal biogenesis factor 7. (325 aa)
TMEM55BPhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (208 aa)
HSD17B103-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
SCP2Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (541 aa)
SPATA9Spermatogenesis-associated protein 9; Belongs to the carnitine/choline acetyltransferase family. (632 aa)
ECHDC2Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (314 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform B; Belongs to the carnitine/choline acetyltransferase family. (638 aa)
TMC4Transmembrane channel-like protein; Belongs to the membrane-bound acyltransferase family. (1083 aa)
PLPPR4acidPPc domain-containing protein. (530 aa)
PLPPR5Lipid phosphate phosphatase-related protein type 5 isoform B. (339 aa)
Y1Q_0007485Uncharacterized protein. (200 aa)
ABCD3ATP-binding cassette sub-family D member 3. (661 aa)
ADIPOQAdiponectin. (263 aa)
HSD17B4Peroxisomal multifunctional enzyme type 2. (739 aa)
AUHMethylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (319 aa)
ETFAElectron transfer flavoprotein subunit alpha, mitochondrial. (334 aa)
MTMR10Myotubularin-related protein 10. (766 aa)
DGKZDiacylglycerol kinase. (1022 aa)
SLC35C1GDP-fucose transporter 1. (369 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (474 aa)
PEX5Peroxisomal biogenesis factor 5 isoform A. (646 aa)
SYNJ1PAX3-and PAX7-binding protein 1. (2276 aa)
CRAT-2Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
CCDC180Coiled-coil domain-containing protein 180. (2011 aa)
INPP5EInositol polyphosphate 5-phosphatase. (450 aa)
PEX13Peroxisome biogenesis factor 13. (398 aa)
SPHK2Sphingosine kinase 2. (591 aa)
HAO1Hydroxyacid oxidase 1. (367 aa)
HADHHydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (277 aa)
FIG4Polyphosphoinositide phosphatase. (907 aa)
Y1Q_00238263-oxoacyl-[acyl-carrier-protein] reductase FabG-like. (201 aa)
ACOX2Uncharacterized protein. (931 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform B. (472 aa)
GCDHGlutaryl-CoA dehydrogenase. (452 aa)
Y1Q_0001159Uncharacterized protein. (191 aa)
MTMR9Myotubularin-related protein 9 isoform A. (530 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (168 aa)
CROTPeroxisomal carnitine O-octanoyltransferase. (612 aa)
Y1Q_0019151Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (456 aa)
DGKBDiacylglycerol kinase. (857 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (573 aa)
HADHATrifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (750 aa)
HADHBTrifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (513 aa)
GBA2Non-lysosomal glucosylceramidase. (597 aa)
MTMR6Myotubularin-related protein 6. (618 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (371 aa)
ECHS1Enoyl-CoA hydratase, mitochondrial isoform B; Belongs to the enoyl-CoA hydratase/isomerase family. (296 aa)
MTMR9-2Myotubularin phosphatase domain-containing protein. (550 aa)
ETFBElectron transfer flavoprotein subunit beta. (257 aa)
ACAA23-ketoacyl-CoA thiolase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
MTMR12Myotubularin-related protein 12. (740 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
PLPP1Lipid phosphate phosphohydrolase 1. (284 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (430 aa)
ABCD1-2ABC transporter domain-containing protein. (250 aa)
CPT1CUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (748 aa)
CARTPTCocaine-and amphetamine-regulated transcript protein. (107 aa)
TMEM130Transmembrane protein 130. (487 aa)
CCDC115Coiled-coil domain-containing protein 115 isoform B. (475 aa)
DGKEDiacylglycerol kinase. (570 aa)
SPHK1Sphingosine kinase 1. (537 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
CYGBCytoglobin; Belongs to the globin family. (180 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase. (537 aa)
ACADSShort-chain specific acyl-CoA dehydrogenase, mitochondrial. (414 aa)
MTMR3Uncharacterized protein. (1166 aa)
MTM1-2Uncharacterized protein. (603 aa)
MTMR1Uncharacterized protein. (655 aa)
ADIPOR2LAdiponectin receptor protein 2. (375 aa)
MBOAT2Lysophospholipid acyltransferase 2; Belongs to the membrane-bound acyltransferase family. (463 aa)
GBAGlucosylceramidase. (779 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (325 aa)
PLPP5Phosphatidate phosphatase PPAPDC1B. (264 aa)
TPTE2Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (511 aa)
ABCD1ATP-binding cassette sub-family D member 1. (387 aa)
PORCN-1Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (465 aa)
INPP5JPhosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform A. (780 aa)
DGKQDiacylglycerol kinase. (973 aa)
PLPPR1Lipid phosphate phosphatase-related protein type 1. (325 aa)
MBOAT1Lysophospholipid acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (475 aa)
Y1Q_0008065Enoyl-CoA delta isomerase 2, mitochondrial-like. (277 aa)
ECI2Enoyl-CoA delta isomerase 2, mitochondrial. (392 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1 isoform A. (1282 aa)
ST3GAL4-1CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform A; Belongs to the glycosyltransferase 29 family. (584 aa)
Y1Q_0003577Uncharacterized protein. (188 aa)
SESN2LSestrin 2. (509 aa)
ECI1Enoyl-CoA delta isomerase 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
Y1Q_0020688Glucosylceramidase. (347 aa)
SMIM24Small integral membrane protein 24. (110 aa)
Y1Q_0011971Uncharacterized protein. (173 aa)
DGKADiacylglycerol kinase. (903 aa)
EHHADHPeroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (727 aa)
SLC25A17Peroxisomal membrane protein PMP34; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
Y1Q_0024247ANK_REP_REGION domain-containing protein. (346 aa)
AGKAcylglycerol kinase, mitochondrial. (429 aa)
DGKIDiacylglycerol kinase. (675 aa)
ADIPOR2Adiponectin receptor protein 2. (387 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (486 aa)
ABCD4ATP-binding cassette sub-family D member 4 isoform B. (642 aa)
SAMD1Atherin. (248 aa)
Y1Q_0015775Lipid phosphate phosphohydrolase 3-like. (280 aa)
MLYCDMalonyl-CoA decarboxylase, mitochondrial. (591 aa)
BDH23-hydroxybutyrate dehydrogenase type 2. (262 aa)
MTMR8Myotubularin phosphatase domain-containing protein. (632 aa)
Y1Q_0015641SH2 domain-containing protein. (1113 aa)
ABCD2ATP-binding cassette sub-family D member 2. (424 aa)
CERKCeramide kinase isoform B. (523 aa)
PHYHPhytanoyl-CoA dioxygenase, peroxisomal. (335 aa)
ACAD10-2Uncharacterized protein; Belongs to the aldehyde dehydrogenase family. (1394 aa)
MTMR11Myotubularin-related protein 11. (710 aa)
MTMR4Myotubularin-related protein 4 isoform A. (1123 aa)
PLPP6Presqualene diphosphate phosphatase. (203 aa)
INPP5FPhosphatidylinositide phosphatase SAC2. (1108 aa)
PLPP4Phosphatidate phosphatase PPAPDC1A. (259 aa)
INPP5D-2SH2 domain-containing protein. (1209 aa)
ILVBLAcetolactate synthase-like protein; Belongs to the TPP enzyme family. (668 aa)
Y1Q_0002522Carnitine O-palmitoyltransferase 1, muscle isoform-like. (94 aa)
CPT1A-2Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (800 aa)
PPARDUncharacterized protein. (442 aa)
PLPPR3Lipid phosphate phosphatase-related protein type 3. (694 aa)
PPAP2CLipid phosphate phosphohydrolase 2. (284 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase. (441 aa)
MTM1Myotubularin isoform B. (650 aa)
Y1Q_0016093Uncharacterized protein. (165 aa)
ACAD10Acyl-CoA dehydrogenase family member 10. (779 aa)
EPHX2Bifunctional epoxide hydrolase 2. (557 aa)
PLPPR2-1Lipid phosphate phosphatase-related protein type 2 isoform B. (381 aa)
ACAT1Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (452 aa)
OCRL-2Rho-GAP domain-containing protein. (931 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (710 aa)
Y1Q_0021372Uncharacterized protein. (499 aa)
Y1Q_0021662Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
CYP4V2Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (618 aa)
MTMR7Uncharacterized protein. (660 aa)
TMEM55A-1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
DECR12,4-dienoyl-CoA reductase, mitochondrial. (336 aa)
Y1Q_0004104Carn_acyltransf domain-containing protein. (87 aa)
CRATCarnitine O-acetyltransferase. (539 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform A. (1485 aa)
ECH1Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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