46 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EMILIN1	EMILIN-1. (1017 aa)
	LEMD3	Inner nuclear membrane protein Man1 isoform B. (622 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)
	ZNF451	Zinc finger protein 451. (741 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	SNX25	Sorting nexin-25. (841 aa)
	RASL11B	Ras-like protein family member 11B isoform A. (245 aa)
	HTRA3	Serine protease HTRA3 isoform B. (405 aa)
	PPARAB	Peroxisome proliferator-activated receptor alpha. (438 aa)
	BCL9L-1	B-cell CLL/lymphoma 9-like protein isoform B. (1409 aa)
	PBLD	Phenazine biosynthesis-like domain-containing protein. (192 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	Y1Q_0002693	Uncharacterized protein. (87 aa)
	SLC2A10	Solute carrier family 2, facilitated glucose transporter member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (423 aa)
	PMEPA1-1	Protein TMEPAI isoform B. (238 aa)
	ZBTB7A	Zinc finger and BTB domain-containing protein 7A. (555 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (159 aa)
	STRAP	Serine-threonine kinase receptor-associated protein. (350 aa)
	CHST11	Carbohydrate sulfotransferase. (402 aa)
	LINGO3	Ig-like domain-containing protein. (605 aa)
	LDLRAD4	Low-density lipoprotein receptor class A domain-containing protein 4. (310 aa)
	Y1Q_0016705	Mothers against decapentaplegic-like protein 6-like. (215 aa)
	VEPH1	Ventricular zone-expressed PH domain-containing protein-like protein 1 isoform A. (832 aa)
	ADAM17	Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
	SKI	Ski oncogene isoform A. (637 aa)
	PRDM16	Uncharacterized protein. (1167 aa)
	SMURF2	E3 ubiquitin-protein ligase. (786 aa)
	SMURF1	E3 ubiquitin-protein ligase. (732 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	SPRED3	Sprouty-related, EVH1 domain-containing protein 3. (700 aa)
	HSPA5	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	IL17RD	Interleukin-17 receptor D. (758 aa)
	SMAD7	Mothers against decapentaplegic homolog. (384 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	SPRED1	Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
	GLG1	Golgi apparatus protein 1. (1180 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	NRROS	Negative regulator of reactive oxygen species. (666 aa)
	ADAMTSL2	ADAMTS-like protein 2 isoform A. (886 aa)
	SKIL	Ski-like protein. (336 aa)
	ADAMTSL2-2	PLAC domain-containing protein. (989 aa)
	FBN1	Uncharacterized protein. (2939 aa)
	SMAD6	Mothers against decapentaplegic homolog. (265 aa)
	FLRT1	Asporin-like. (221 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform A. (951 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAMBI	SMAD6	A0A151PCV5	A0A151M8V2	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.854
BAMBI	SMAD7	A0A151PCV5	A0A151MWS7	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.821
BAMBI	Y1Q_0016705	A0A151PCV5	A0A151NFJ8	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic-like protein 6-like.	0.647
CAV1	CAV2	A0A151PF23	A0A151PEZ6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.992
CAV1	CAV3	A0A151PF23	A0A151MKB4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.902
CAV2	CAV1	A0A151PEZ6	A0A151PF23	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.992
CAV2	CAV3	A0A151PEZ6	A0A151MKB4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.992
CAV3	CAV1	A0A151MKB4	A0A151PF23	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.902
CAV3	CAV2	A0A151MKB4	A0A151PEZ6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.992
FLRT1	LINGO3	A0A151M317	A0A151NGT6	Asporin-like.	Ig-like domain-containing protein.	0.483
HSPA5	TP53	A0A151MZK0	A0A151MW63	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.405
LINGO3	FLRT1	A0A151NGT6	A0A151M317	Ig-like domain-containing protein.	Asporin-like.	0.483
PBLD	STRAP	A0A151P1G3	A0A151NJ11	Phenazine biosynthesis-like domain-containing protein.	Serine-threonine kinase receptor-associated protein.	0.656
PIN1	TP53	A0A151NVS2	A0A151MW63	Peptidyl-prolyl cis-trans isomerase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.792
PPARAB	PRDM16	A0A151P784	A0A151N3L3	Peroxisome proliferator-activated receptor alpha.	Uncharacterized protein.	0.436
PPARAB	SIRT1	A0A151P784	A0A151P0R7	Peroxisome proliferator-activated receptor alpha.	NAD-dependent protein deacetylase sirtuin-1.	0.803
PRDM16	PPARAB	A0A151N3L3	A0A151P784	Uncharacterized protein.	Peroxisome proliferator-activated receptor alpha.	0.436
SIRT1	PPARAB	A0A151P0R7	A0A151P784	NAD-dependent protein deacetylase sirtuin-1.	Peroxisome proliferator-activated receptor alpha.	0.803
SIRT1	TP53	A0A151P0R7	A0A151MW63	NAD-dependent protein deacetylase sirtuin-1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
SKI	SKIL	A0A151N3N3	A0A151MGE9	Ski oncogene isoform A.	Ski-like protein.	0.609