(23 nodes) cAMP binding network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (873 aa)
	Y1Q_0011506	Rap guanine nucleotide exchange factor 4-like. (169 aa)
	PDE10A	Phosphodiesterase. (814 aa)
	RAPGEF3	Uncharacterized protein. (874 aa)
	BVES	Blood vessel epicardial substance isoform A. (448 aa)
	POPDC3	Popeye domain-containing protein 3. (161 aa)
	Y1Q_0023772	Uncharacterized protein. (599 aa)
	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit. (355 aa)
	HCN4	Cyclic nucleotide-binding domain-containing protein. (770 aa)
	CNGA1	cGMP-gated cation channel alpha-1; Belongs to the G-protein coupled receptor 1 family. (839 aa)
	PDE2A	Phosphodiesterase. (925 aa)
	HCN3	Cyclic nucleotide-binding domain-containing protein. (628 aa)
	Y1Q_0005328	Cyclic nucleotide-binding domain-containing protein. (578 aa)
	HCN1-2	Cyclic nucleotide-binding domain-containing protein. (507 aa)
	PRKAR1B	Uncharacterized protein. (413 aa)
	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
	CNBD2-1	Cyclic nucleotide-binding domain-containing protein 2 isoform B. (591 aa)
	CNGA2-2	Cyclic nucleotide-binding domain-containing protein. (717 aa)
	PRKAR2B	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B. (408 aa)
	HCN1	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (794 aa)
	Y1Q_0021608	Cyclic nucleotide-binding domain-containing protein. (327 aa)
	Y1Q_0021609	Uncharacterized protein. (110 aa)
	RAPGEF2-2	Uncharacterized protein. (1669 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNGA1	CNGA2-2	A0A151MLB5	A0A151NMR9	cGMP-gated cation channel alpha-1; Belongs to the G-protein coupled receptor 1 family.	Cyclic nucleotide-binding domain-containing protein.	0.885
CNGA2-2	CNGA1	A0A151NMR9	A0A151MLB5	Cyclic nucleotide-binding domain-containing protein.	cGMP-gated cation channel alpha-1; Belongs to the G-protein coupled receptor 1 family.	0.885
PRKAR1A	PRKAR1B	A0A151N2J0	A0A151N1Z1	cAMP-dependent protein kinase type I-alpha regulatory subunit.	Uncharacterized protein.	0.900
PRKAR1A	PRKAR2A	A0A151N2J0	A0A151MKS7	cAMP-dependent protein kinase type I-alpha regulatory subunit.	cAMP-dependent protein kinase type II-alpha regulatory subunit.	0.904
PRKAR1A	PRKAR2B	A0A151N2J0	A0A151NPC1	cAMP-dependent protein kinase type I-alpha regulatory subunit.	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	0.904
PRKAR1B	PRKAR1A	A0A151N1Z1	A0A151N2J0	Uncharacterized protein.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.900
PRKAR1B	PRKAR2A	A0A151N1Z1	A0A151MKS7	Uncharacterized protein.	cAMP-dependent protein kinase type II-alpha regulatory subunit.	0.904
PRKAR1B	PRKAR2B	A0A151N1Z1	A0A151NPC1	Uncharacterized protein.	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	0.904
PRKAR2A	PRKAR1A	A0A151MKS7	A0A151N2J0	cAMP-dependent protein kinase type II-alpha regulatory subunit.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.904
PRKAR2A	PRKAR1B	A0A151MKS7	A0A151N1Z1	cAMP-dependent protein kinase type II-alpha regulatory subunit.	Uncharacterized protein.	0.904
PRKAR2A	PRKAR2B	A0A151MKS7	A0A151NPC1	cAMP-dependent protein kinase type II-alpha regulatory subunit.	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	0.901
PRKAR2B	PRKAR1A	A0A151NPC1	A0A151N2J0	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	cAMP-dependent protein kinase type I-alpha regulatory subunit.	0.904
PRKAR2B	PRKAR1B	A0A151NPC1	A0A151N1Z1	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	Uncharacterized protein.	0.904
PRKAR2B	PRKAR2A	A0A151NPC1	A0A151MKS7	cAMP-dependent protein kinase type II-beta regulatory subunit isoform B.	cAMP-dependent protein kinase type II-alpha regulatory subunit.	0.901
RAPGEF3	RAPGEF5	A0A151M663	A0A151M006	Uncharacterized protein.	Rap guanine nucleotide exchange factor 5.	0.943
RAPGEF3	Y1Q_0011506	A0A151M663	A0A151M009	Uncharacterized protein.	Rap guanine nucleotide exchange factor 4-like.	0.891
RAPGEF5	RAPGEF3	A0A151M006	A0A151M663	Rap guanine nucleotide exchange factor 5.	Uncharacterized protein.	0.943
RAPGEF5	Y1Q_0011506	A0A151M006	A0A151M009	Rap guanine nucleotide exchange factor 5.	Rap guanine nucleotide exchange factor 4-like.	0.900
Y1Q_0011506	RAPGEF3	A0A151M009	A0A151M663	Rap guanine nucleotide exchange factor 4-like.	Uncharacterized protein.	0.891
Y1Q_0011506	RAPGEF5	A0A151M009	A0A151M006	Rap guanine nucleotide exchange factor 4-like.	Rap guanine nucleotide exchange factor 5.	0.900