STRINGSTRING
AKAP8 AKAP8 PINK1 PINK1 JDP2 JDP2 SDR16C5-1 SDR16C5-1 Y1Q_0003831 Y1Q_0003831 SDR16C5-2 SDR16C5-2 TP53 TP53 NIPBL NIPBL SAP30BP SAP30BP RRP8 RRP8 LRRK2 LRRK2 TGFB1 TGFB1 SIRT1 SIRT1 ING2 ING2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKAP8A-kinase anchor protein 8 isoform B; Belongs to the AKAP95 family. (669 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial; Belongs to the arginase family. (851 aa)
JDP2Jun dimerization protein 2. (173 aa)
SDR16C5-1Epidermal retinol dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (281 aa)
Y1Q_0003831Epidermal retinol dehydrogenase 2-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
SDR16C5-2Epidermal retinol dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (367 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
NIPBLNipped-B protein. (2617 aa)
SAP30BPSAP30-binding protein. (311 aa)
RRP8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (108 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
ING2Inhibitor of growth protein. (228 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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