90 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GSK3B-2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
	SLC27A4	AMP-binding domain-containing protein. (650 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
	AKT3-2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ITM2B	Integral membrane protein 2B isoform B. (1151 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1. (515 aa)
	CPEB1	Cytoplasmic polyadenylation element-binding protein 1 isoform D. (595 aa)
	INPP5K	Inositol polyphosphate 5-phosphatase K isoform B. (472 aa)
	RAB15	Ras-related protein Rab-15. (212 aa)
	Y1Q_0003905	Ras-related protein Rab-10-like. (194 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (168 aa)
	AKT2	Non-specific serine/threonine protein kinase. (270 aa)
	RAB10	Ras-related protein Rab-10. (189 aa)
	BCAR1	Breast cancer anti-estrogen resistance protein 1. (960 aa)
	Y1Q_0004544	Pribosyltran domain-containing protein. (100 aa)
	APRT	Adenine phosphoribosyltransferase-like. (180 aa)
	Y1Q_0023097	Adenine phosphoribosyltransferase-like. (216 aa)
	ZNF106	Zinc finger protein 106. (1384 aa)
	USF1	Upstream stimulatory factor 1 isoform B. (349 aa)
	NCOA5	Nuclear receptor coactivator 5. (559 aa)
	PIK3R1-2	Uncharacterized protein. (750 aa)
	PTPRA-2	Uncharacterized protein. (1013 aa)
	APPL1	DCC-interacting protein 13-alpha. (708 aa)
	SYAP1	Synapse-associated protein 1. (312 aa)
	GSK3B	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (413 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (677 aa)
	STXBP4	Syntaxin-binding protein 4. (681 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	PRKCZ-2	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
	LPIN1	Phosphatidate phosphatase LPIN1 isoform B. (975 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (727 aa)
	IRS1	Insulin receptor substrate 1 isoform B. (809 aa)
	GOT1L1-1	Putative aspartate aminotransferase, cytoplasmic 2 isoform C. (590 aa)
	RAB12	Ras-related protein Rab-12 isoform A. (247 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)
	RAB13	Ras-related protein Rab-13. (256 aa)
	Y1Q_0003612	Rho-GAP domain-containing protein. (189 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)
	ANKRD26	Ankyrin repeat domain-containing protein 26 isoform A. (824 aa)
	INSR	Tyrosine-protein kinase receptor. (1353 aa)
	CAPN10	Calpain-10 isoform A; Belongs to the peptidase C2 family. (629 aa)
	GCLC	Glutamate--cysteine ligase catalytic subunit. (604 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (180 aa)
	GHRHR	Growth hormone-releasing hormone receptor isoform A; Belongs to the G-protein coupled receptor 2 family. (424 aa)
	Y1Q_0017424	Uncharacterized protein. (235 aa)
	CPEB2	Uncharacterized protein. (495 aa)
	OTOP1	Otopetrin-1. (537 aa)
	GOT1	Aspartate aminotransferase. (412 aa)
	SP1	Transcription factor Sp1. (746 aa)
	EPRS	Bifunctional glutamate/proline--tRNA ligase isoform A. (1676 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
	DENND4C	UDENN domain-containing protein. (1770 aa)
	EIF4EBP2	Eukaryotic translation initiation factor 4E-binding protein 2. (115 aa)
	LPIN3	LNS2 domain-containing protein. (944 aa)
	PCK1	Uncharacterized protein. (679 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	INSR-2	Tyrosine-protein kinase receptor. (1352 aa)
	RAB8A-1	Ras-related protein Rab-8A isoform B. (274 aa)
	CYFIP1-2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1289 aa)
	SOGA1	Protein SOGA1 isoform A. (1537 aa)
	FOXO4	Forkhead box protein O4. (480 aa)
	TRIB3	Tribbles-like protein 3. (340 aa)
	SLC27A1	Long-chain fatty acid transport protein 1. (743 aa)
	Y1Q_0015723	Uncharacterized protein. (379 aa)
	Y1Q_0015722	Receptor-type tyrosine-protein phosphatase T-like. (566 aa)
	Y1Q_0015648	G_PROTEIN_RECEP_F1_2 domain-containing protein. (154 aa)
	IRS2	Insulin receptor substrate 2. (1149 aa)
	ZDHHC7	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (261 aa)
	Y1Q_0007228	Uncharacterized protein. (492 aa)
	XBP1	X-box-binding protein 1. (286 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1. (664 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (802 aa)
	C2CD5	C2 domain-containing protein 5 isoform A. (1076 aa)
	Y1Q_0003573	SH3 domain-containing protein. (167 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (429 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (814 aa)
	RAB31	Ras-related protein Rab-31. (195 aa)
	RARRES2	Retinoic acid receptor responder protein 2. (156 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (453 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (233 aa)
	DNAI1	Dynein intermediate chain 1, axonemal. (711 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (882 aa)
	DCAF11	DDB1-and CUL4-associated factor 11. (1208 aa)
	ADIPOQ	Adiponectin. (263 aa)
	GHSR	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1363 aa)
	RAB8B	Ras-related protein Rab-8B. (126 aa)
	CSRP3	Cysteine and glycine-rich protein 3. (210 aa)
	IGF2-1	Insulin-like growth factor II isoform B. (217 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	A0A151M626	A0A151MZ93	Adiponectin.	DCC-interacting protein 13-alpha.	0.716
ADIPOQ	LEP	A0A151M626	A0A151MPN9	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.900
ADIPOQ	PPARG	A0A151M626	A0A151PJ63	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.765
ADIPOQ	RARRES2	A0A151M626	A0A151LYA0	Adiponectin.	Retinoic acid receptor responder protein 2.	0.403
AKT2	AKT3	A0A151MPY5	A0A151M239	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT2	AKT3-2	A0A151MPY5	A0A151MH49	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.902
AKT2	APPL1	A0A151MPY5	A0A151MZ93	Non-specific serine/threonine protein kinase.	DCC-interacting protein 13-alpha.	0.821
AKT2	FOXO4	A0A151MPY5	A0A151NVV9	Non-specific serine/threonine protein kinase.	Forkhead box protein O4.	0.969
AKT2	GSK3B	A0A151MPY5	A0A151N132	Non-specific serine/threonine protein kinase.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.545
AKT2	GSK3B-2	A0A151MPY5	A0A151MD62	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.952
AKT2	PDPK1	A0A151MPY5	A0A151MHZ4	Non-specific serine/threonine protein kinase.	3-phosphoinositide-dependent protein kinase 1.	0.851
AKT2	PIK3R1	A0A151MPY5	A0A151N8Y8	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.943
AKT2	PIK3R1-2	A0A151MPY5	A0A151MXN9	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.943
AKT2	TRIB3	A0A151MPY5	A0A151NVV1	Non-specific serine/threonine protein kinase.	Tribbles-like protein 3.	0.704
AKT2	Y1Q_0003573	A0A151MPY5	A0A151NGA7	Non-specific serine/threonine protein kinase.	SH3 domain-containing protein.	0.461
AKT2	Y1Q_0003612	A0A151MPY5	A0A151PFY9	Non-specific serine/threonine protein kinase.	Rho-GAP domain-containing protein.	0.461
AKT2	Y1Q_0017424	A0A151MPY5	A0A151PCN9	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.899
AKT3	AKT2	A0A151M239	A0A151MPY5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.902
AKT3	AKT3-2	A0A151M239	A0A151MH49	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
AKT3	APPL1	A0A151M239	A0A151MZ93	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha.	0.821