STRINGSTRING
IKBKB-2 IKBKB-2 RIPK1 RIPK1 TNFRSF11A TNFRSF11A ZC3H12A ZC3H12A CDIP1 CDIP1 Y1Q_0020688 Y1Q_0020688 CLDN18 CLDN18 TNFRSF13C TNFRSF13C NFKBIA NFKBIA CARD14 CARD14 IRG1 IRG1 AKAP12 AKAP12 EDA2R-1 EDA2R-1 PRPF8 PRPF8 GATA3 GATA3 CD14 CD14 TNF TNF Y1Q_0008573 Y1Q_0008573 CCL38A.5 CCL38A.5 CCL4 CCL4 Y1Q_0013293 Y1Q_0013293 Y1Q_0013292 Y1Q_0013292 GCH1-2 GCH1-2 TNFSF13B TNFSF13B Y1Q_0004900 Y1Q_0004900 Y1Q_0004897 Y1Q_0004897 Y1Q_0004899 Y1Q_0004899 ANKRD1 ANKRD1 OCSTAMP OCSTAMP Y1Q_0020515 Y1Q_0020515 SIRT1 SIRT1 CXCL8-3 CXCL8-3 TRAF5 TRAF5 ZFP36L2 ZFP36L2 Y1Q_0004713 Y1Q_0004713 NKX3-1-1 NKX3-1-1 YBX3 YBX3 SMPD1 SMPD1 TNFRSF19 TNFRSF19 Y1Q_0007360 Y1Q_0007360 TRAF3 TRAF3 ASAH1 ASAH1 BRCA1 BRCA1 NR1D1 NR1D1 NUB1 NUB1 IKBKB IKBKB CRHBP CRHBP YTHDC2 YTHDC2 TNFRSF21 TNFRSF21 TNFRSF1B TNFRSF1B RELT-1 RELT-1 CYP1B1 CYP1B1 TNFSF11 TNFSF11 TRAF1-1 TRAF1-1 ADAMTS13 ADAMTS13 TRAF2 TRAF2 HYAL3-1 HYAL3-1 TNFRSF1A TNFRSF1A XCL1 XCL1 CD58 CD58 Y1Q_0002953 Y1Q_0002953 MYOD1 MYOD1 TRAF6 TRAF6 ZFP36L1 ZFP36L1 ADAM10 ADAM10 ZFAND6 ZFAND6 ADIPOQ ADIPOQ NMNAT3 NMNAT3 RPS3 RPS3 MAP2K7 MAP2K7 TANK TANK NFE2L2 NFE2L2 Y1Q_0017727 Y1Q_0017727 KRT8 KRT8 DHX9 DHX9 TRAF3IP2 TRAF3IP2 INPP5K INPP5K TRADD TRADD SMPD3 SMPD3 CLDN1 CLDN1 ST18 ST18 DFNA5 DFNA5 CCL17 CCL17 CX3CL1 CX3CL1 TNFRSF19L TNFRSF19L Y1Q_0021908 Y1Q_0021908 Y1Q_0015961 Y1Q_0015961 CD40 CD40 Y1Q_0015232 Y1Q_0015232 TP53 TP53 Y1Q_0009802 Y1Q_0009802 DCSTAMP DCSTAMP IFI16 IFI16 ILK ILK LITAFL LITAFL TMEM130 TMEM130 Y1Q_0014359 Y1Q_0014359 GFER GFER GCH1-1 GCH1-1 TNFRSF18L TNFRSF18L SMPD4 SMPD4 TXNDC17 TXNDC17 IL8L1 IL8L1 Y1Q_0013039 Y1Q_0013039 Y1Q_0013038 Y1Q_0013038 CCL1 CCL1 CIB1 CIB1 CCL21 CCL21 GBA GBA CASP18 CASP18 CASP10 CASP10 CCL20 CCL20 CASP8-1 CASP8-1 PID1 PID1 Y1Q_0017705 Y1Q_0017705 BAG4 BAG4 CACTIN CACTIN PYCARDL PYCARDL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKB-2Uncharacterized protein. (757 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (699 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (669 aa)
ZC3H12ARibonuclease ZC3H12A. (389 aa)
CDIP1Cell death-inducing p53-target protein 1. (259 aa)
Y1Q_0020688Glucosylceramidase. (347 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (260 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C. (216 aa)
NFKBIANF-kappa-B inhibitor alpha. (299 aa)
CARD14Caspase recruitment domain-containing protein 14 isoform B. (1051 aa)
IRG1Cis-aconitate decarboxylase. (474 aa)
AKAP12A-kinase anchor protein 12. (1999 aa)
EDA2R-1Tumor necrosis factor receptor superfamily member 27 isoform B. (596 aa)
PRPF8Pre-mRNA-processing-splicing factor 8. (2260 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
CD14Monocyte differentiation antigen CD14. (461 aa)
TNFTumor necrosis factor. (231 aa)
Y1Q_0008573TNF receptor-associated factor 1-like. (331 aa)
CCL38A.5SCY domain-containing protein. (83 aa)
CCL4C-C motif chemokine. (91 aa)
Y1Q_0013293C-C motif chemokine. (102 aa)
Y1Q_0013292C-C motif chemokine 5-like. (91 aa)
GCH1-2GTP cyclohydrolase 1 isoform A. (216 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (246 aa)
Y1Q_0004900Uncharacterized protein. (226 aa)
Y1Q_0004897Uncharacterized protein. (202 aa)
Y1Q_0004899Death domain-containing protein. (80 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (286 aa)
Y1Q_0020515Pyrin domain-containing protein. (72 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (588 aa)
ZFP36L2Tis11B_N domain-containing protein. (90 aa)
Y1Q_0004713C-C motif chemokine 19-like. (72 aa)
NKX3-1-1Homeobox protein Nkx-3.1 isoform A. (238 aa)
YBX3Y-box-binding protein 3. (221 aa)
SMPD1Sphingomyelin phosphodiesterase. (287 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19. (163 aa)
Y1Q_0007360Uncharacterized protein. (493 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (553 aa)
ASAH1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
BRCA1Breast cancer type 1 susceptibility protein. (832 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (555 aa)
NUB1NEDD8 ultimate buster 1. (673 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (730 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
YTHDC2Putative ATP-dependent RNA helicase YTHDC2. (1413 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21. (642 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (467 aa)
RELT-1Tumor necrosis factor receptor superfamily member 19L isoform A. (534 aa)
CYP1B1Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (551 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (271 aa)
TRAF1-1TNF receptor-associated factor 1 isoform C. (723 aa)
ADAMTS13A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform B. (1597 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (601 aa)
HYAL3-1Hyaluronidase. (644 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (412 aa)
XCL1Lymphotactin. (192 aa)
CD58CD48 antigen. (264 aa)
Y1Q_0002953Uncharacterized protein. (68 aa)
MYOD1Myogenic factor. (293 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (576 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (335 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (748 aa)
ZFAND6AN1-type zinc finger protein 6. (124 aa)
ADIPOQAdiponectin. (263 aa)
NMNAT3Nicotinamide-nucleotide adenylyltransferase. (241 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (278 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform C. (488 aa)
TANKTRAF family member-associated NF-kappa-B activator. (472 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (482 aa)
Y1Q_0017727Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (422 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (427 aa)
DHX9ATP-dependent RNA helicase A. (1546 aa)
TRAF3IP2Adapter protein CIKS. (557 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform B. (472 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (336 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (642 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
ST18MYT1 domain-containing protein. (1107 aa)
DFNA5Non-syndromic hearing impairment protein 5. (486 aa)
CCL17C-C motif chemokine. (137 aa)
CX3CL1Fractalkine. (118 aa)
TNFRSF19LTumor necrosis factor receptor superfamily member 19. (130 aa)
Y1Q_0021908Uncharacterized protein. (1693 aa)
Y1Q_0015961Uncharacterized protein; Belongs to the cytochrome P450 family. (247 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (300 aa)
Y1Q_0015232UBA_6 domain-containing protein. (145 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Y1Q_0009802Uncharacterized protein. (1345 aa)
DCSTAMPDendritic cell-specific transmembrane protein. (165 aa)
IFI16Gamma-interferon-inducible protein 16. (169 aa)
ILKIntegrin-linked protein kinase. (452 aa)
LITAFLLipopolysaccharide-induced tumor necrosis factor-alpha factor. (174 aa)
TMEM130Transmembrane protein 130. (487 aa)
Y1Q_0014359Sulfhydryl oxidase. (171 aa)
GFERSulfhydryl oxidase. (192 aa)
GCH1-1GTP cyclohydrolase 1. (233 aa)
TNFRSF18LTumor necrosis factor receptor superfamily member 4 isoform C. (298 aa)
SMPD4Sphingomyelin phosphodiesterase 4 isoform A. (829 aa)
TXNDC17Thioredoxin domain-containing protein 17. (122 aa)
IL8L1Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
Y1Q_0013039C-C motif chemokine. (90 aa)
Y1Q_0013038C-C motif chemokine. (90 aa)
CCL1Chemokine (C-C motif) ligand 1. (96 aa)
CIB1Calcium and integrin-binding protein 1. (190 aa)
CCL21SCY domain-containing protein. (93 aa)
GBAGlucosylceramidase. (779 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (424 aa)
CASP10Caspase-10 isoform B; Belongs to the peptidase C14A family. (489 aa)
CCL20C-C motif chemokine. (86 aa)
CASP8-1Caspase-8 isoform B; Belongs to the peptidase C14A family. (462 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein. (217 aa)
Y1Q_0017705TBD domain-containing protein. (264 aa)
BAG4BAG family molecular chaperone regulator 4. (387 aa)
CACTINCactin. (641 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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