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CHEK1 CHEK1 ZBTB1 ZBTB1 Y1Q_0000158 Y1Q_0000158 PTPRM PTPRM EIF2S1 EIF2S1 USP47 USP47 HYAL3-1 HYAL3-1 CUNH9orf116 CUNH9orf116 OPN3 OPN3 POLH POLH CASP9 CASP9 XPC XPC MMP9 MMP9 BMF BMF EIF2AK4 EIF2AK4 INO80 INO80 TP53 TP53 TP53INP1-1 TP53INP1-1 ERCC1 ERCC1 TIMP1 TIMP1 ERCC4 ERCC4 NOC2L NOC2L PBK PBK DHX36 DHX36 ATR ATR RHBDD1 RHBDD1 XPA XPA CREBBPA CREBBPA CREBBP CREBBP Y1Q_0024039 Y1Q_0024039 Y1Q_0008411 Y1Q_0008411 BAX BAX RUVBL2 RUVBL2 CUL4B CUL4B Y1Q_0015515 Y1Q_0015515 CUL4A CUL4A DDB1 DDB1 ACTR5 ACTR5 TMEM161B TMEM161B SIRT1 SIRT1 STK11 STK11 Y1Q_0007595 Y1Q_0007595 SDE2 SDE2 PARP1 PARP1 METTL3 METTL3 BAK1 BAK1 MC1R MC1R PCNA PCNA RHNO1 RHNO1 SMPD1 SMPD1 PPID PPID AQP1 AQP1 MFAP4 MFAP4 ZMPSTE24 ZMPSTE24 IMPACT IMPACT POLK POLK OPN5 OPN5 POLD3-1 POLD3-1 POLD1 POLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (471 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (710 aa)
Y1Q_0000158Uncharacterized protein. (139 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform C. (1440 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (352 aa)
USP47Ubiquitin carboxyl-terminal hydrolase 47 isoform A; Belongs to the peptidase C19 family. (1356 aa)
HYAL3-1Hyaluronidase. (644 aa)
CUNH9orf116Uncharacterized protein. (137 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
POLHDNA polymerase eta. (707 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (423 aa)
XPCDNA repair protein complementing XP-C cells. (955 aa)
MMP9Uncharacterized protein. (684 aa)
BMFBcl-2-modifying factor. (217 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1613 aa)
INO80DNA helicase INO80. (1539 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
TP53INP1-1Tumor protein p53-inducible nuclear protein 1 isoform B. (225 aa)
ERCC1DNA excision repair protein ERCC-1. (329 aa)
TIMP1Metalloproteinase inhibitor 1. (224 aa)
ERCC4DNA repair endonuclease XPF. (903 aa)
NOC2LNucleolar complex 2-like protein. (785 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (325 aa)
DHX36ATP-dependent RNA helicase DHX36. (991 aa)
ATRSerine/threonine-protein kinase ATR isoform A; Belongs to the PI3/PI4-kinase family. (2392 aa)
RHBDD1Rhomboid-related protein 4. (221 aa)
XPADNA repair protein complementing XP-A cells. (244 aa)
CREBBPACREB-binding protein isoform A. (1756 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
Y1Q_0008411Apoptosis regulator BAX-like. (187 aa)
BAXApoptosis regulator BAX. (209 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (461 aa)
CUL4BCullin-4B; Belongs to the cullin family. (614 aa)
Y1Q_0015515Cullin domain-containing protein; Belongs to the cullin family. (160 aa)
CUL4ACULLIN_2 domain-containing protein; Belongs to the cullin family. (763 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
ACTR5Actin-related protein 5; Belongs to the actin family. (557 aa)
TMEM161BTransmembrane protein 161B. (489 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (418 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
SDE2SDE2-like protein. (397 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
METTL3N6-adenosine-methyltransferase subunit; Belongs to the MT-A70-like family. (419 aa)
BAK1Bcl-2-like proteinous antagonist/killer. (222 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (318 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
RHNO1RAD9. (261 aa)
SMPD1Sphingomyelin phosphodiesterase. (287 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
MFAP4Microfibril-associated glycoprotein 4. (256 aa)
ZMPSTE24CAAX prenyl protease 1-like protein. (1233 aa)
IMPACTProtein IMPACT isoform B; Belongs to the G-protein coupled receptor 1 family. (511 aa)
POLKDNA polymerase kappa isoform A. (651 aa)
OPN5Opsin-5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
POLD3-1DNA polymerase delta subunit 3 isoform A. (466 aa)
POLD1DNA polymerase. (439 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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