STRINGSTRING
VCP VCP CREB3L2 CREB3L2 FOXRED2 FOXRED2 Y1Q_0024039 Y1Q_0024039 PLA2G6 PLA2G6 ATF4-2 ATF4-2 CREBBP CREBBP CLGN-2 CLGN-2 UBE2G2 UBE2G2 SESN2L SESN2L FAM214BL FAM214BL QRICH1 QRICH1 USP19 USP19 Y1Q_0001042 Y1Q_0001042 Y1Q_0017188 Y1Q_0017188 Y1Q_0021145 Y1Q_0021145 UFM1 UFM1 ERLIN2 ERLIN2 RHBDD1 RHBDD1 SERP1 SERP1 TBL2 TBL2 IL8L1 IL8L1 ATP2A3 ATP2A3 RHBDD2 RHBDD2 DERL2 DERL2 DERL3 DERL3 RNF185 RNF185 FBXO2 FBXO2 UBE4B UBE4B FBXO6 FBXO6 TMX1 TMX1 ERN1 ERN1 ANKS4B ANKS4B GET4 GET4 FAM8A1 FAM8A1 MBTPS2 MBTPS2 UBXN6 UBXN6 HSPA5 HSPA5 FAF2 FAF2 P4HB P4HB DDRGK1 DDRGK1 TMEM67 TMEM67 RNF139 RNF139 DERL1 DERL1 SGTB SGTB TTC23L TTC23L TTC33 TTC33 TP53 TP53 OS9 OS9 Y1Q_0019558 Y1Q_0019558 CHAC1 CHAC1 EIF2AK4 EIF2AK4 THBS2 THBS2 NRBF2-1 NRBF2-1 RASGRF1 RASGRF1 SYVN1 SYVN1 AMFR AMFR PDX1 PDX1 HERPUD1 HERPUD1 CREB3 CREB3 STT3B-2 STT3B-2 NHLRC1 NHLRC1 Y1Q_0018529 Y1Q_0018529 CALR CALR EDEM1 EDEM1 RNF186 RNF186 TMCO1 TMCO1 EDEM3 EDEM3 HM13 HM13 EIF2AK2 EIF2AK2 TMX4 TMX4 SEL1L2 SEL1L2 ERLEC1 ERLEC1 Y1Q_0005598 Y1Q_0005598 MAN1B1 MAN1B1 RNF183 RNF183 CREB3L1 CREB3L1 EIF2S1 EIF2S1 YOD1 YOD1 PML PML FAM214A-1 FAM214A-1 VIMP VIMP PARP16 PARP16 ERMP1 ERMP1 CLGN CLGN USP5 USP5 AUP1 AUP1 SEL1L SEL1L UFC1 UFC1 FAF1 FAF1 PARK2L PARK2L PARK2 PARK2 JKAMP JKAMP BCL2L11-1 BCL2L11-1 UBXN4 UBXN4 NFE2L2 NFE2L2 DNAJC10 DNAJC10 APAF1 APAF1 ERP27 ERP27 TMTC3 TMTC3 ANKZF1 ANKZF1 c-jun c-jun ATF6B ATF6B RNF121 RNF121 PDIA3 PDIA3 RNF5 RNF5 CREB3L4 CREB3L4 RASGRF2 RASGRF2 ATG10 ATG10 Y1Q_0004044 Y1Q_0004044 SEC61B SEC61B MARCH6 MARCH6 ERP44 ERP44 JUND JUND ERLIN1 ERLIN1 FAM214B FAM214B UBE4A UBE4A TMEM117 TMEM117 DNAJB9 DNAJB9 CFTR CFTR EIF2B5 EIF2B5 ERO1B ERO1B PSMC6 PSMC6 TMUB2 TMUB2 CCDC47 CCDC47 SEL1L3 SEL1L3 TMEM33 TMEM33 WFS1 WFS1 RNF103 RNF103 EIF2AK3 EIF2AK3 PDIA2 PDIA2 CDK5RAP3 CDK5RAP3 BAK1 BAK1 ATF3 ATF3 PDIA4 PDIA4 UBA5 UBA5 HERPUD2 HERPUD2 CXCL8-3 CXCL8-3 TMEM259 TMEM259 DNAJB12 DNAJB12 PTPN1 PTPN1 CEBPB CEBPB VAPB VAPB NCK2 NCK2 Y1Q_0007000 Y1Q_0007000 BAG6 BAG6 CREB3L3-1 CREB3L3-1 Y1Q_0022324 Y1Q_0022324 TRIB3 TRIB3 UGGT1 UGGT1 SRPX SRPX ATF4-1 ATF4-1 Y1Q_0024190 Y1Q_0024190 Y1Q_0008411 Y1Q_0008411 BAX BAX PPP1R15A PPP1R15A DNAJB2 DNAJB2 XBP1 XBP1 DNAJB14 DNAJB14 AIFM1 AIFM1 DNAJC18 DNAJC18 Y1Q_0018103 Y1Q_0018103 DNAJC3 DNAJC3 UFD1L UFD1L UGGT2 UGGT2 TMED2 TMED2 FICD FICD TMTC4 TMTC4 ATF6 ATF6 UFL1 UFL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCPUncharacterized protein; Belongs to the AAA ATPase family. (880 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
FOXRED2FAD-dependent oxidoreductase domain-containing protein 2 isoform A. (758 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
PLA2G685/calcium-independent phospholipase A2. (840 aa)
ATF4-2Cyclic AMP-dependent transcription factor ATF-4. (124 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
CLGN-2Uncharacterized protein. (665 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
SESN2LSestrin 2. (509 aa)
FAM214BLProtein FAM214B. (361 aa)
QRICH1Glutamine-rich protein 1. (780 aa)
USP19Ubiquitin carboxyl-terminal hydrolase 19 isoform A. (1473 aa)
Y1Q_0001042Proteasome-associated ECM29-like protein. (1841 aa)
Y1Q_0017188Uncharacterized protein. (164 aa)
Y1Q_0021145Uncharacterized protein. (945 aa)
UFM1Ubiquitin-fold modifier 1. (149 aa)
ERLIN2Erlin-2. (364 aa)
RHBDD1Rhomboid-related protein 4. (221 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
TBL2Transducin beta-like protein 2. (441 aa)
IL8L1Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1043 aa)
RHBDD2Rhomboid domain-containing protein 2. (135 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (242 aa)
RNF185E3 ubiquitin-protein ligase RNF185. (194 aa)
FBXO2F-box only protein 2. (277 aa)
UBE4BUbiquitin conjugation factor E4 B. (1173 aa)
FBXO6F-box only protein 6. (257 aa)
TMX1Thioredoxin-related transmembrane protein 1. (275 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (1027 aa)
ANKS4BAnkyrin repeat and SAM domain-containing protein 4B. (438 aa)
GET4Golgi to ER traffic 4-like protein. (283 aa)
FAM8A1Protein FAM8A1 isoform A. (195 aa)
MBTPS2Membrane-bound transcription factor site-2 protease. (494 aa)
UBXN6UBX domain-containing protein 6. (439 aa)
HSPA5Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
FAF2FAS-associated factor 2. (416 aa)
P4HBProtein disulfide-isomerase. (512 aa)
DDRGK1DDRGK domain-containing protein 1. (297 aa)
TMEM67Meckelin isoform A. (984 aa)
RNF139Uncharacterized protein. (83 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (252 aa)
SGTBSmall glutamine-rich tetratricopeptide repeat-containing protein beta. (356 aa)
TTC23LTetratricopeptide repeat protein 23-like. (416 aa)
TTC33Tetratricopeptide repeat protein 33. (319 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
OS9Protein OS-9. (461 aa)
Y1Q_0019558Protein OS-9-like. (118 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1613 aa)
THBS2Thrombospondin-2. (1224 aa)
NRBF2-1Nuclear receptor-binding factor 2 isoform B. (298 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform B. (1198 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin. (661 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (578 aa)
PDX1Pancreas/duodenum homeobox protein 1. (206 aa)
HERPUD1annotation not available (342 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (368 aa)
STT3B-2Uncharacterized protein. (804 aa)
NHLRC1E3 ubiquitin-protein ligase NHLRC1. (400 aa)
Y1Q_0018529Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
CALRCalreticulin. (356 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (516 aa)
RNF186RING finger protein 186. (289 aa)
TMCO1Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (188 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (857 aa)
HM13Minor histocompatibility antigen H13. (369 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (532 aa)
TMX4Thioredoxin-related transmembrane protein 4. (267 aa)
SEL1L2Uncharacterized protein. (658 aa)
ERLEC1Endoplasmic reticulum lectin 1. (537 aa)
Y1Q_0005598alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (822 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (668 aa)
RNF183RING finger protein 183. (235 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (502 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (352 aa)
YOD1Ubiquitin thioesterase OTU1. (304 aa)
PMLProtein PML isoform B. (586 aa)
FAM214A-1Protein FAM214A isoform B. (937 aa)
VIMPSelenoprotein S. (189 aa)
PARP16Poly [ADP-ribose] polymerase. (268 aa)
ERMP1Endoplasmic reticulum metallopeptidase 1. (813 aa)
CLGNCalmegin. (1443 aa)
USP5Ubiquitin carboxyl-terminal hydrolase. (875 aa)
AUP1Ancient ubiquitous protein 1. (369 aa)
SEL1LSel-1-like protein 1. (791 aa)
UFC1Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage. (164 aa)
FAF1FAS-associated factor 1. (745 aa)
PARK2LRBR-type E3 ubiquitin transferase. (180 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform A. (280 aa)
JKAMPJNK1/MAPK8-associated membrane protein. (312 aa)
BCL2L11-1Bcl-2-like protein 11 isoform C. (178 aa)
UBXN4UBX domain-containing protein 4. (507 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (482 aa)
DNAJC10DnaJ-like protein subfamily C member 10. (813 aa)
APAF1Apoptotic protease-activating factor 1. (1276 aa)
ERP27Endoplasmic reticulum resident protein 27. (265 aa)
TMTC3Transmembrane and TPR repeat-containing protein 3 isoform A. (693 aa)
ANKZF1Ankyrin repeat and zinc finger domain-containing protein 1. (488 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (666 aa)
RNF121RING finger protein 121. (353 aa)
PDIA3Protein disulfide-isomerase. (450 aa)
RNF5E3 ubiquitin-protein ligase RNF5-like. (90 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform A. (417 aa)
RASGRF2Uncharacterized protein. (1171 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10. (263 aa)
Y1Q_0004044PH domain-containing protein. (118 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
MARCH6E3 ubiquitin-protein ligase MARCH6 isoform B. (839 aa)
ERP44Endoplasmic reticulum resident protein 44. (426 aa)
JUNDBZIP domain-containing protein. (87 aa)
ERLIN1Erlin-1. (335 aa)
FAM214BProtein FAM214B. (195 aa)
UBE4AUbiquitin conjugation factor E4 A. (1072 aa)
TMEM117Transmembrane protein 117 isoform B. (574 aa)
DNAJB9DnaJ-like protein subfamily B member 9. (274 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1500 aa)
EIF2B5Translation initiation factor eIF-2B subunit epsilon. (714 aa)
ERO1BERO1-like protein beta. (446 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
TMUB2Transmembrane and ubiquitin-like domain-containing protein 2. (277 aa)
CCDC47Coiled-coil domain-containing protein 47 isoform B. (533 aa)
SEL1L3Sel-1-like protein 3. (1070 aa)
TMEM33Transmembrane protein 33. (251 aa)
WFS1Wolframin. (387 aa)
RNF103E3 ubiquitin-protein ligase RNF103. (314 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform B. (976 aa)
PDIA2Protein disulfide-isomerase. (539 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3. (534 aa)
BAK1Bcl-2-like proteinous antagonist/killer. (222 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (220 aa)
PDIA4Protein disulfide-isomerase. (669 aa)
UBA5Ubiquitin-like modifier-activating enzyme 5. (402 aa)
HERPUD2Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein. (399 aa)
CXCL8-3Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
TMEM259Membralin isoform B. (746 aa)
DNAJB12DnaJ-like protein subfamily B member 12. (364 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CEBPBCCAAT/enhancer-binding protein beta. (141 aa)
VAPBVesicle-associated membrane protein-associated protein B/C. (228 aa)
NCK2Cytoplasmic protein NCK2. (301 aa)
Y1Q_0007000Uncharacterized protein. (504 aa)
BAG6Large proline-rich protein BAG6. (945 aa)
CREB3L3-1Cyclic AMP-responsive element-binding protein 3-like protein 3 isoform B. (499 aa)
Y1Q_0022324Uncharacterized protein. (900 aa)
TRIB3Tribbles-like protein 3. (340 aa)
UGGT1UDP-glucose:glycoprotein glucosyltransferase 1 isoform A. (1595 aa)
SRPXSushi repeat-containing protein SRPX isoform A. (451 aa)
ATF4-1Cyclic AMP-dependent transcription factor ATF-4. (117 aa)
Y1Q_0024190HATPase_c domain-containing protein. (755 aa)
Y1Q_0008411Apoptosis regulator BAX-like. (187 aa)
BAXApoptosis regulator BAX. (209 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (374 aa)
DNAJB2DnaJ-like protein subfamily B member 2. (204 aa)
XBP1X-box-binding protein 1. (286 aa)
DNAJB14DnaJ-like protein subfamily B member 14. (380 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial. (603 aa)
DNAJC18DnaJ-like protein subfamily C member 18. (301 aa)
Y1Q_0018103Ankyrin repeat and zinc finger domain-containing protein 1-like. (118 aa)
DNAJC3DnaJ-like protein subfamily C member 3. (488 aa)
UFD1LUbiquitin fusion degradation 1-like protein. (307 aa)
UGGT2Uncharacterized protein. (1490 aa)
TMED2Transmembrane emp24 domain-containing protein 2 isoform B. (201 aa)
FICDAdenosine monophosphate-protein transferase FICD. (456 aa)
TMTC4Transmembrane and TPR repeat-containing protein 4. (740 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (673 aa)
UFL1E3 UFM1-protein ligase 1. (793 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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