(26 nodes) Endodermal cell differentiation network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SETD2	Histone-lysine N-methyltransferase SETD2 isoform C. (1911 aa)
	ITGA4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1036 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	LEO1	RNA polymerase-associated protein LEO1. (653 aa)
	CTR9	RNA polymerase-associated CTR9-like protein. (1135 aa)
	COL8A1	Collagen alpha-1(VIII) chain. (761 aa)
	LAMB3	Laminin subunit beta-3 isoform B. (1232 aa)
	MMP9	Uncharacterized protein. (684 aa)
	EOMES	Eomesodermin-like protein isoform B. (404 aa)
	ITGA5	Integrin alpha-5. (671 aa)
	MMP15-2	ZnMc domain-containing protein. (709 aa)
	Y1Q_0014200	Nuclear receptor subfamily 0 group B member 2-like. (369 aa)
	RTF1	RNA polymerase-associated RTF1-like protein. (233 aa)
	MMP14	ZnMc domain-containing protein. (570 aa)
	PAF1	RNA polymerase II-associated factor 1-like protein. (503 aa)
	HNF1B	Homeobox domain-containing protein. (562 aa)
	FN1	Fibronectin isoform A. (2483 aa)
	ITGAV-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
	Y1Q_0018553	Integrin alpha-5-like. (167 aa)
	CDC73	Parafibromin. (531 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (130 aa)
	VTN	Vitronectin. (324 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	Y1Q_0017506	TGF_BETA_2 domain-containing protein. (424 aa)
	HMGA2	High mobility group protein HMGI-C. (112 aa)
	GATA6	Transcription factor GATA-6. (325 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC73	CTNNB1	A0A151NLW4	A0A151P2N9	Parafibromin.	Catenin beta-1 isoform B.	0.854
CDC73	CTR9	A0A151NLW4	A0A151MBW6	Parafibromin.	RNA polymerase-associated CTR9-like protein.	0.998
CDC73	LEO1	A0A151NLW4	A0A151M9Q8	Parafibromin.	RNA polymerase-associated protein LEO1.	0.999
CDC73	PAF1	A0A151NLW4	A0A151MZY1	Parafibromin.	RNA polymerase II-associated factor 1-like protein.	0.999
CDC73	RTF1	A0A151NLW4	A0A151MVA7	Parafibromin.	RNA polymerase-associated RTF1-like protein.	0.994
CDC73	SETD2	A0A151NLW4	A0A151MUS7	Parafibromin.	Histone-lysine N-methyltransferase SETD2 isoform C.	0.556
CTNNB1	CDC73	A0A151P2N9	A0A151NLW4	Catenin beta-1 isoform B.	Parafibromin.	0.854
CTNNB1	EOMES	A0A151P2N9	A0A151MQY6	Catenin beta-1 isoform B.	Eomesodermin-like protein isoform B.	0.501
CTNNB1	HMGA2	A0A151P2N9	A0A151PFG5	Catenin beta-1 isoform B.	High mobility group protein HMGI-C.	0.477
CTNNB1	LEO1	A0A151P2N9	A0A151M9Q8	Catenin beta-1 isoform B.	RNA polymerase-associated protein LEO1.	0.934
CTNNB1	MMP9	A0A151P2N9	A0A151MM81	Catenin beta-1 isoform B.	Uncharacterized protein.	0.462
CTR9	CDC73	A0A151MBW6	A0A151NLW4	RNA polymerase-associated CTR9-like protein.	Parafibromin.	0.998
CTR9	LEO1	A0A151MBW6	A0A151M9Q8	RNA polymerase-associated CTR9-like protein.	RNA polymerase-associated protein LEO1.	0.999
CTR9	PAF1	A0A151MBW6	A0A151MZY1	RNA polymerase-associated CTR9-like protein.	RNA polymerase II-associated factor 1-like protein.	0.998
CTR9	RTF1	A0A151MBW6	A0A151MVA7	RNA polymerase-associated CTR9-like protein.	RNA polymerase-associated RTF1-like protein.	0.994
CTR9	SETD2	A0A151MBW6	A0A151MUS7	RNA polymerase-associated CTR9-like protein.	Histone-lysine N-methyltransferase SETD2 isoform C.	0.686
EOMES	CTNNB1	A0A151MQY6	A0A151P2N9	Eomesodermin-like protein isoform B.	Catenin beta-1 isoform B.	0.501
EOMES	GATA6	A0A151MQY6	A0A151PGM5	Eomesodermin-like protein isoform B.	Transcription factor GATA-6.	0.496
FN1	ITGA4	A0A151N9H9	A0A151LZP9	Fibronectin isoform A.	Integrin alpha-4; Belongs to the integrin alpha chain family.	0.919
FN1	ITGA5	A0A151N9H9	A0A151MRH6	Fibronectin isoform A.	Integrin alpha-5.	0.935