STRINGSTRING
GOT2 GOT2 CATIP CATIP PNKD PNKD INDOL1 INDOL1 COQ7 COQ7 HAGHL HAGHL CACNA1I CACNA1I HAGH HAGH UBIAD1 UBIAD1 COQ5 COQ5 VKORC1L1 VKORC1L1 HSD17B1 HSD17B1 Y1Q_0008596 Y1Q_0008596 COQ10B COQ10B KMO KMO GLOD4 GLOD4 COQ8B COQ8B SRD5A1 SRD5A1 HSD11B2 HSD11B2 NQO2 NQO2 AFMID AFMID KDSR KDSR COQ6 COQ6 EDNRB EDNRB NQO1 NQO1 COQ3 COQ3 CYP17A1 CYP17A1 SCNN1B SCNN1B SIRT6 SIRT6 PDDC1-1 PDDC1-1 AIFM2 AIFM2 COQ2 COQ2 GLO1 GLO1 ADCK3 ADCK3 COQ10A COQ10A STARD3 STARD3 NDUFA9 NDUFA9 Y1Q_0007371 Y1Q_0007371 AKR1A1-1 AKR1A1-1 Y1Q_0004975 Y1Q_0004975 PDSS1 PDSS1 NMT1 NMT1 CBR4 CBR4 TDO2 TDO2 Y1Q_0021751 Y1Q_0021751 AADAT AADAT CYP46A1 CYP46A1 ALDH8A1 ALDH8A1 KYNU KYNU PARK7 PARK7 CCBL2 CCBL2 HSD17B10 HSD17B10 IDO1 IDO1 CYP21A2 CYP21A2 CRYZL1 CRYZL1 TPI1 TPI1 HSD17B3 HSD17B3 CCBL1 CCBL1 SRD5A2 SRD5A2 COQ4 COQ4 CBR1 CBR1 PDSS2 PDSS2 COQ9 COQ9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GOT2Aspartate aminotransferase. (589 aa)
CATIPCiliogenesis-associated TTC17-interacting protein isoform B. (731 aa)
PNKDPutative hydrolase PNKD. (119 aa)
INDOL1Indoleamine 2,3-dioxygenase 2. (240 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (207 aa)
HAGHLHydroxyacylglutathione hydrolase-like protein. (282 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha-1I isoform B. (2248 aa)
HAGHHydroxyacylglutathione hydrolase, mitochondrial. (308 aa)
UBIAD1UbiA prenyltransferase domain-containing protein 1. (345 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (317 aa)
VKORC1L1Vitamin K epoxide reductase complex subunit 1-like protein 1. (176 aa)
HSD17B1Estradiol 17-beta-dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (295 aa)
Y1Q_0008596Coenzyme Q-binding COQ10-like protein B, mitochondrial-like. (225 aa)
COQ10BCoenzyme Q-binding COQ10-like protein B, mitochondrial. (246 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (461 aa)
GLOD4Glyoxalase domain-containing protein 4. (270 aa)
COQ8BABC1 domain-containing protein. (365 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (263 aa)
HSD11B2Corticosteroid 11-beta-dehydrogenase isozyme 2 isoform A. (429 aa)
NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]. (281 aa)
AFMIDKynurenine formamidase. (171 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (333 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (424 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (275 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (341 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (507 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (655 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
PDDC1-1Parkinson disease 7 domain-containing protein 1 isoform B. (219 aa)
AIFM2Apoptosis-inducing factor 2 isoform B. (522 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial. (200 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (180 aa)
ADCK3Atypical kinase ADCK3, mitochondrial. (682 aa)
COQ10ACoenzyme Q-binding COQ10-like protein A, mitochondrial. (162 aa)
STARD3StAR-related lipid transfer protein 3. (444 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (382 aa)
Y1Q_0007371G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
AKR1A1-1Alcohol dehydrogenase [NADP(+)] isoform A. (381 aa)
Y1Q_0004975Vitamin K epoxide reductase complex subunit 1-like protein 1. (155 aa)
PDSS1Decaprenyl-diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (367 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (495 aa)
CBR4Carbonyl reductase family member 4. (237 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
Y1Q_0021751Uncharacterized protein. (131 aa)
AADATKynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform A. (435 aa)
CYP46A1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
ALDH8A1Aldehyde dehydrogenase family 8 member A1; Belongs to the aldehyde dehydrogenase family. (475 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (506 aa)
PARK7Protein deglycase DJ-1. (159 aa)
CCBL2Kynurenine--oxoglutarate transaminase 3 isoform B. (471 aa)
HSD17B103-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
IDO1Indoleamine 2,3-dioxygenase 2. (152 aa)
CYP21A2Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (320 aa)
CRYZL1Quinone oxidoreductase-like protein 1. (349 aa)
TPI1Triosephosphate isomerase. (248 aa)
HSD17B3Testosterone 17-beta-dehydrogenase 3 isoform C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (299 aa)
CCBL1Kynurenine--oxoglutarate transaminase 1. (305 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (261 aa)
COQ4Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (244 aa)
CBR1Carbonyl reductase [NADPH] 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
PDSS2Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (389 aa)
COQ9Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (311 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.