STRINGSTRING
BTRC BTRC OPN5 OPN5 SFPQ SFPQ THRAP3 THRAP3 NR1D1 NR1D1 FBXW7-2 FBXW7-2 PPARGC1A PPARGC1A PSPC1 PSPC1 PPARAB PPARAB Y1Q_0019415 Y1Q_0019415 NPS NPS Y1Q_0020627 Y1Q_0020627 PPP1CA PPP1CA ADCY1 ADCY1 CRTC1 CRTC1 DDB1 DDB1 UBE3A UBE3A DRD4 DRD4 SIRT6 SIRT6 PER1 PER1 FBL12 FBL12 NONO NONO PPP1CC PPP1CC HDAC3 HDAC3 Y1Q_0004859 Y1Q_0004859 SUV39H2 SUV39H2 Y1Q_0019536 Y1Q_0019536 OPN4 OPN4 FBXL3-2 FBXL3-2 CRY1 CRY1 CSNK1E-2 CSNK1E-2 NOCT NOCT RORAL RORAL CRY2 CRY2 PHLPP1 PHLPP1 TIMELESS TIMELESS SLC39A14 SLC39A14 NR1D4A NR1D4A FBXW7 FBXW7 ROCK2 ROCK2 FBXW9 FBXW9 TARDBP TARDBP MTOR MTOR USP7 USP7 KLF10 KLF10 PRKAA1-2 PRKAA1-2 TP53 TP53 CDK1 CDK1 SRRD SRRD PPP1CA-2 PPP1CA-2 NR1D2 NR1D2 FBXL8 FBXL8 ATG7 ATG7 CIPC CIPC MAPK8 MAPK8 BHLHE40 BHLHE40 GHRL-1 GHRL-1 Y1Q_0018245 Y1Q_0018245 ARNTL ARNTL CRY2-2 CRY2-2 PML PML RORA RORA FBXL22 FBXL22 RORB RORB CSNK1E CSNK1E MAPK9 MAPK9 FBXL3 FBXL3 Y1Q_0021893 Y1Q_0021893 RORC RORC PRKAA1 PRKAA1 SUV39H1 SUV39H1 PPARG PPARG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTRCF-box/WD repeat-containing protein 1A isoform B. (626 aa)
OPN5Opsin-5; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SFPQSplicing factor, proline-and glutamine-rich isoform B. (717 aa)
THRAP3Thyroid hormone receptor-associated protein 3. (659 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (555 aa)
FBXW7-2Uncharacterized protein. (674 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform A. (555 aa)
PSPC1Paraspeckle component 1 isoform A. (526 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
Y1Q_0019415Uncharacterized protein. (85 aa)
NPSNeuropeptide S. (162 aa)
Y1Q_0020627Uncharacterized protein. (92 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (347 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform A. (584 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (877 aa)
DRD4D(4) dopamine receptor isoform A; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
PER1Period circadian protein-like protein 3. (1366 aa)
FBL12F-box/LRR-repeat protein 12. (319 aa)
NONONon-POU domain-containing octamer-binding protein. (618 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
Y1Q_0004859Uncharacterized protein. (512 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (407 aa)
Y1Q_0019536Mitogen-activated protein kinase. (505 aa)
OPN4Opsin 4xa. (553 aa)
FBXL3-2F-box domain-containing protein. (455 aa)
CRY1Cryptochrome 4. (665 aa)
CSNK1E-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa)
NOCTNocturnin. (420 aa)
RORALNuclear receptor ROR-alpha. (465 aa)
CRY2Cryptochrome-2. (506 aa)
PHLPP1PPM-type phosphatase domain-containing protein. (1207 aa)
TIMELESSTimeless-like protein. (616 aa)
SLC39A14Zinc transporter ZIP14. (1452 aa)
NR1D4ANuclear receptor subfamily 1, group D, member 4a. (431 aa)
FBXW7F-box/WD repeat-containing protein 7. (665 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
FBXW9F-box/WD repeat-containing protein 9. (457 aa)
TARDBPTAR DNA-binding protein 43. (481 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1080 aa)
KLF10Krueppel-like factor 10. (121 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
SRRDSRR1-like protein. (201 aa)
PPP1CA-2Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform B. (589 aa)
FBXL8F-box/LRR-repeat protein 8. (385 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (815 aa)
CIPCCLOCK-interacting pacemaker. (185 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BHLHE40Class E basic helix-loop-helix protein 40 isoform B. (283 aa)
GHRL-1Appetite-regulating hormone isoform B. (145 aa)
Y1Q_0018245Timeless-like protein. (364 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B. (651 aa)
CRY2-2Photolyase/cryptochrome alpha/beta domain-containing protein. (547 aa)
PMLProtein PML isoform B. (586 aa)
RORANuclear receptor ROR-alpha isoform B. (468 aa)
FBXL22F-box and leucine-rich protein 22. (141 aa)
RORBUncharacterized protein. (459 aa)
CSNK1ECasein kinase I isoform B; Belongs to the protein kinase superfamily. (446 aa)
MAPK9Mitogen-activated protein kinase. (430 aa)
FBXL3F-box/LRR-repeat protein 3. (397 aa)
Y1Q_0021893PAS domain-containing protein. (1057 aa)
RORCNuclear receptor ROR-gamma. (521 aa)
PRKAA1Non-specific serine/threonine protein kinase. (527 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (346 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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