STRINGSTRING
CHEK2 CHEK2 SIRT1 SIRT1 DDIT4 DDIT4 TMEM109 TMEM109 MSH2 MSH2 BAG6 BAG6 Y1Q_0024039 Y1Q_0024039 CREBBP CREBBP CDIP1 CDIP1 PYCARDL PYCARDL Y1Q_0017188 Y1Q_0017188 Y1Q_0006003 Y1Q_0006003 ATAD5 ATAD5 LITAFL LITAFL TP53 TP53 BRCA2 BRCA2 TP63 TP63 PML PML SNW1 SNW1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Serine/threonine-protein kinase Chk2 isoform B. (433 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
DDIT4DNA damage-inducible transcript 4 protein. (172 aa)
TMEM109Transmembrane protein 109. (182 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa)
BAG6Large proline-rich protein BAG6. (945 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
CDIP1Cell death-inducing p53-target protein 1. (259 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
Y1Q_0017188Uncharacterized protein. (164 aa)
Y1Q_0006003Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (688 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1673 aa)
LITAFLLipopolysaccharide-induced tumor necrosis factor-alpha factor. (174 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
BRCA2Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
PMLProtein PML isoform B. (586 aa)
SNW1SNW domain-containing protein 1. (536 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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