STRINGSTRING
Y1Q_0022355 Y1Q_0022355 LEXM LEXM PIK3CB PIK3CB AAED1 AAED1 FAM214A-1 FAM214A-1 PTH PTH IGF2-1 IGF2-1 ZBTB20 ZBTB20 APP APP IFNAR1 IFNAR1 TACO1 TACO1 PNPT1 PNPT1 OPN3 OPN3 Y1Q_0004590 Y1Q_0004590 HTR2A HTR2A DNAJC15 DNAJC15 PINK1 PINK1 PASK PASK INPP5K INPP5K IFNLR1 IFNLR1 Y1Q_0018542 Y1Q_0018542 NOA1 NOA1 PPP1R3B PPP1R3B NDUFA4 NDUFA4 COX7A2 COX7A2 CDK1 CDK1 TP53 TP53 PRKAA1-2 PRKAA1-2 GLTSCR2 GLTSCR2 PDE12 PDE12 FLCN FLCN GTF2IRD2 GTF2IRD2 PRDM16 PRDM16 MTOR MTOR MLXIPL MLXIPL FAM214BL FAM214BL CREBBP CREBBP Y1Q_0024039 Y1Q_0024039 METTL20 METTL20 AK4 AK4 P2RX7 P2RX7 OGT OGT Y1Q_0006556 Y1Q_0006556 KHK-1 KHK-1 EIF6 EIF6 ZBTB7A ZBTB7A SIRT6 SIRT6 PPP1R3D PPP1R3D PPP1R3C PPP1R3C DDIT4 DDIT4 IDE IDE COX7A2L COX7A2L MNF1 MNF1 TIGAR TIGAR PPARAB PPARAB NKX1-1 NKX1-1 PPARGC1A PPARGC1A STAT4 STAT4 Y1Q_0013170 Y1Q_0013170 PPP1R3A PPP1R3A PRELID1 PRELID1 FAM214B FAM214B HSP75 HSP75
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y1Q_0022355General transcription factor II-I repeat domain-containing protein 2B-like. (502 aa)
LEXMUncharacterized protein. (404 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AAED1Thioredoxin-like protein AAED1 isoform A. (244 aa)
FAM214A-1Protein FAM214A isoform B. (937 aa)
PTHParathyroid hormone. (126 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20. (769 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (743 aa)
IFNAR1Interferon alpha/beta receptor 1. (569 aa)
TACO1Translational activator of cytochrome c oxidase 1. (358 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (769 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
Y1Q_0004590DUF4206 domain-containing protein. (677 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
DNAJC15DnaJ-like protein subfamily C member 15. (145 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial; Belongs to the arginase family. (851 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1329 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform B. (472 aa)
IFNLR1Interferon lambda receptor 1. (570 aa)
Y1Q_0018542Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (627 aa)
NOA1Nitric oxide-associated protein 1. (659 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (301 aa)
NDUFA4Cytochrome c oxidase subunit NDUFA4. (82 aa)
COX7A2Cytochrome c oxidase subunit 7A2, mitochondrial. (89 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
PRKAA1-2Non-specific serine/threonine protein kinase. (547 aa)
GLTSCR2Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (409 aa)
PDE122',5'-phosphodiesterase 12. (423 aa)
FLCNFolliculin. (629 aa)
GTF2IRD2General transcription factor II-I repeat domain-containing protein 2A isoform A. (496 aa)
PRDM16Uncharacterized protein. (1167 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
MLXIPLCarbohydrate-responsive element-binding protein. (711 aa)
FAM214BLProtein FAM214B. (361 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
METTL20Protein N-lysine methyltransferase METTL20. (241 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (469 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit isoform B. (1075 aa)
Y1Q_0006556Uncharacterized protein. (176 aa)
KHK-1Ketohexokinase isoform B. (304 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
ZBTB7AZinc finger and BTB domain-containing protein 7A. (555 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (202 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (330 aa)
DDIT4DNA damage-inducible transcript 4 protein. (172 aa)
IDEInsulin-degrading enzyme isoform A; Belongs to the peptidase M16 family. (1026 aa)
COX7A2LCytochrome c oxidase subunit VIIa polypeptide 2 like. (116 aa)
MNF1Ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform A. (123 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (272 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
NKX1-1Homeobox protein SAX-1. (386 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform A. (555 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
Y1Q_0013170Uncharacterized protein. (100 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1235 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial. (215 aa)
FAM214BProtein FAM214B. (195 aa)
HSP75Heat shock protein, mitochondrial. (708 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (18%) [HD]