node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | CREBBP | A0A151MDY4 | A0A151NHH3 | BPTI/Kunitz inhibitor domain-containing protein. | CREB-binding protein isoform C. | 0.447 |
APP | SCARB2 | A0A151MDY4 | A0A151MN87 | BPTI/Kunitz inhibitor domain-containing protein. | Lysosome membrane protein 2; Belongs to the CD36 family. | 0.491 |
APP | Y1Q_0024039 | A0A151MDY4 | A0A151NHX4 | BPTI/Kunitz inhibitor domain-containing protein. | KIX domain-containing protein. | 0.447 |
CREBBP | APP | A0A151NHH3 | A0A151MDY4 | CREB-binding protein isoform C. | BPTI/Kunitz inhibitor domain-containing protein. | 0.447 |
CREBBP | PPARAB | A0A151NHH3 | A0A151P784 | CREB-binding protein isoform C. | Peroxisome proliferator-activated receptor alpha. | 0.692 |
CREBBP | STAT4 | A0A151NHH3 | A0A151PC08 | CREB-binding protein isoform C. | Signal transducer and activator of transcription. | 0.897 |
CREBBP | TP53 | A0A151NHH3 | A0A151MW63 | CREB-binding protein isoform C. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.993 |
DDIT4 | TP53 | A0A151NZU3 | A0A151MW63 | DNA damage-inducible transcript 4 protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.519 |
PPARAB | CREBBP | A0A151P784 | A0A151NHH3 | Peroxisome proliferator-activated receptor alpha. | CREB-binding protein isoform C. | 0.692 |
PPARAB | SCARB2 | A0A151P784 | A0A151MN87 | Peroxisome proliferator-activated receptor alpha. | Lysosome membrane protein 2; Belongs to the CD36 family. | 0.564 |
PPARAB | Y1Q_0024039 | A0A151P784 | A0A151NHX4 | Peroxisome proliferator-activated receptor alpha. | KIX domain-containing protein. | 0.692 |
PRKAA1-2 | TP53 | A0A151MX04 | A0A151MW63 | Non-specific serine/threonine protein kinase. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.432 |
SCARB2 | APP | A0A151MN87 | A0A151MDY4 | Lysosome membrane protein 2; Belongs to the CD36 family. | BPTI/Kunitz inhibitor domain-containing protein. | 0.491 |
SCARB2 | PPARAB | A0A151MN87 | A0A151P784 | Lysosome membrane protein 2; Belongs to the CD36 family. | Peroxisome proliferator-activated receptor alpha. | 0.564 |
SIRT6 | TP53 | A0A151NX83 | A0A151MW63 | NAD-dependent protein deacetylase sirtuin-6. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.482 |
STAT4 | CREBBP | A0A151PC08 | A0A151NHH3 | Signal transducer and activator of transcription. | CREB-binding protein isoform C. | 0.897 |
STAT4 | TP53 | A0A151PC08 | A0A151MW63 | Signal transducer and activator of transcription. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.778 |
STAT4 | Y1Q_0024039 | A0A151PC08 | A0A151NHX4 | Signal transducer and activator of transcription. | KIX domain-containing protein. | 0.897 |
TIGAR | TP53 | A0A151P6J9 | A0A151MW63 | Fructose-2,6-bisphosphatase TIGAR. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.601 |
TP53 | CREBBP | A0A151MW63 | A0A151NHH3 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | CREB-binding protein isoform C. | 0.993 |