20 items (Alligator mississippiensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

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Your Input:
	AAED1	Thioredoxin-like protein AAED1 isoform A. (244 aa)
	ZBTB20	Zinc finger and BTB domain-containing protein 20. (769 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (743 aa)
	HTR2A	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	SCARB2	Lysosome membrane protein 2; Belongs to the CD36 family. (482 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	PRKAA1-2	Non-specific serine/threonine protein kinase. (547 aa)
	FLCN	Folliculin. (629 aa)
	MLXIPL	Carbohydrate-responsive element-binding protein. (711 aa)
	CREBBP	CREB-binding protein isoform C. (2208 aa)
	Y1Q_0024039	KIX domain-containing protein. (131 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (469 aa)
	OGT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase subunit isoform B. (1075 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (245 aa)
	ZBTB7A	Zinc finger and BTB domain-containing protein 7A. (555 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (357 aa)
	DDIT4	DNA damage-inducible transcript 4 protein. (172 aa)
	TIGAR	Fructose-2,6-bisphosphatase TIGAR. (272 aa)
	PPARAB	Peroxisome proliferator-activated receptor alpha. (438 aa)
	STAT4	Signal transducer and activator of transcription. (849 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	CREBBP	A0A151MDY4	A0A151NHH3	BPTI/Kunitz inhibitor domain-containing protein.	CREB-binding protein isoform C.	0.447
APP	SCARB2	A0A151MDY4	A0A151MN87	BPTI/Kunitz inhibitor domain-containing protein.	Lysosome membrane protein 2; Belongs to the CD36 family.	0.491
APP	Y1Q_0024039	A0A151MDY4	A0A151NHX4	BPTI/Kunitz inhibitor domain-containing protein.	KIX domain-containing protein.	0.447
CREBBP	APP	A0A151NHH3	A0A151MDY4	CREB-binding protein isoform C.	BPTI/Kunitz inhibitor domain-containing protein.	0.447
CREBBP	PPARAB	A0A151NHH3	A0A151P784	CREB-binding protein isoform C.	Peroxisome proliferator-activated receptor alpha.	0.692
CREBBP	STAT4	A0A151NHH3	A0A151PC08	CREB-binding protein isoform C.	Signal transducer and activator of transcription.	0.897
CREBBP	TP53	A0A151NHH3	A0A151MW63	CREB-binding protein isoform C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.993
DDIT4	TP53	A0A151NZU3	A0A151MW63	DNA damage-inducible transcript 4 protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.519
PPARAB	CREBBP	A0A151P784	A0A151NHH3	Peroxisome proliferator-activated receptor alpha.	CREB-binding protein isoform C.	0.692
PPARAB	SCARB2	A0A151P784	A0A151MN87	Peroxisome proliferator-activated receptor alpha.	Lysosome membrane protein 2; Belongs to the CD36 family.	0.564
PPARAB	Y1Q_0024039	A0A151P784	A0A151NHX4	Peroxisome proliferator-activated receptor alpha.	KIX domain-containing protein.	0.692
PRKAA1-2	TP53	A0A151MX04	A0A151MW63	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.432
SCARB2	APP	A0A151MN87	A0A151MDY4	Lysosome membrane protein 2; Belongs to the CD36 family.	BPTI/Kunitz inhibitor domain-containing protein.	0.491
SCARB2	PPARAB	A0A151MN87	A0A151P784	Lysosome membrane protein 2; Belongs to the CD36 family.	Peroxisome proliferator-activated receptor alpha.	0.564
SIRT6	TP53	A0A151NX83	A0A151MW63	NAD-dependent protein deacetylase sirtuin-6.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.482
STAT4	CREBBP	A0A151PC08	A0A151NHH3	Signal transducer and activator of transcription.	CREB-binding protein isoform C.	0.897
STAT4	TP53	A0A151PC08	A0A151MW63	Signal transducer and activator of transcription.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.778
STAT4	Y1Q_0024039	A0A151PC08	A0A151NHX4	Signal transducer and activator of transcription.	KIX domain-containing protein.	0.897
TIGAR	TP53	A0A151P6J9	A0A151MW63	Fructose-2,6-bisphosphatase TIGAR.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.601
TP53	CREBBP	A0A151MW63	A0A151NHH3	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	CREB-binding protein isoform C.	0.993