(64 nodes) Multi-multicellular organism process network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MST1	Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
	Y1Q_0021687	Uncharacterized protein. (139 aa)
	CORIN	Atrial natriuretic peptide-converting enzyme isoform A. (1045 aa)
	Y1Q_0007360	Uncharacterized protein. (493 aa)
	MED1-2	Uncharacterized protein. (259 aa)
	EPOR	Erythropoietin receptor isoform B. (458 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1104 aa)
	VDR	Vitamin D3 receptor isoform B. (480 aa)
	Y1Q_0017513	Mediator of RNA polymerase II transcription subunit 1-like. (204 aa)
	Y1Q_0017512	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (345 aa)
	ENDOU	Poly(U)-specific endoribonuclease. (274 aa)
	A1CF	APOBEC1 complementation factor isoform A. (595 aa)
	JUNB	Transcription factor jun-B. (292 aa)
	PPARD	Uncharacterized protein. (442 aa)
	STS	Steryl-sulfatase. (355 aa)
	TEKT3	Tektin-3 isoform B. (536 aa)
	PRDX3-1	Thioredoxin-dependent peroxide reductase, mitochondrial isoform A. (385 aa)
	TMED2	Transmembrane emp24 domain-containing protein 2 isoform B. (201 aa)
	ACSL3	Long-chain-fatty-acid--CoA ligase 3. (670 aa)
	HYAL3-1	Hyaluronidase. (644 aa)
	DDR2	Discoidin domain-containing receptor 2 isoform A. (941 aa)
	PTGS2	Prostaglandin G/H synthase 2. (605 aa)
	PRDM1	PR domain zinc finger protein 1. (833 aa)
	GHRL-1	Appetite-regulating hormone isoform B. (145 aa)
	PGF-1	Placenta growth factor isoform A; Belongs to the PDGF/VEGF growth factor family. (219 aa)
	MMP9	Uncharacterized protein. (684 aa)
	PITHD1	PITH domain-containing protein 1. (192 aa)
	PRDM14	PR domain zinc finger protein 14. (193 aa)
	TCF24	Transcription factor 24. (171 aa)
	OXT	Neurophysin 1; Belongs to the vasopressin/oxytocin family. (124 aa)
	FOSL1	Fos-related antigen 1. (272 aa)
	Y1Q_0022503	Steryl-sulfatase-like. (187 aa)
	Y1Q_0015648	G_PROTEIN_RECEP_F1_2 domain-containing protein. (154 aa)
	Y1Q_0023549	Uncharacterized protein. (378 aa)
	ITGB4	Integrin beta. (1833 aa)
	LIF	Leukemia inhibitory factor. (211 aa)
	VMP1	Vacuole membrane protein 1. (392 aa)
	ASH1L	Histone-lysine N-methyltransferase ASH1L isoform A. (1798 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	SERPINE2	Glia-derived nexin; Belongs to the serpin family. (428 aa)
	THBD	Thrombomodulin isoform A. (545 aa)
	HSD11B2	Corticosteroid 11-beta-dehydrogenase isozyme 2 isoform A. (429 aa)
	TPPP3	Tubulin polymerization-promoting protein family member 3 isoform B. (254 aa)
	Y1Q_0010480	Uncharacterized protein. (311 aa)
	PRL	Prolactin. (236 aa)
	PLA2G6	85/calcium-independent phospholipase A2. (840 aa)
	PTN	Pleiotrophin. (165 aa)
	IRG1	Cis-aconitate decarboxylase. (474 aa)
	AR	Androgen receptor. (634 aa)
	SP3	Transcription factor Sp3. (766 aa)
	IGFBP5-2	IGFBP N-terminal domain-containing protein. (144 aa)
	IGFBP5	Insulin-like growth factor-binding protein 5. (184 aa)
	Y1Q_0009490	Poly(U)-specific endoribonuclease-like. (90 aa)
	GHSR	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (341 aa)
	ABCC8-2	Uncharacterized protein. (1594 aa)
	POLR1B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1078 aa)
	PAM	Peptidyl-glycine alpha-amidating monooxygenase isoform B. (871 aa)
	HEXB-2	Uncharacterized protein. (441 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	RECK	Reversion-inducing cysteine-rich protein with Kazal motifs. (937 aa)
	Y1Q_0019754	Prolactin-like. (99 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	RXFP1-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (619 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	MED1	A0A151NNF7	A0A151P5B9	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.488
AR	MED1-2	A0A151NNF7	A0A151P5D7	Androgen receptor.	Uncharacterized protein.	0.488
AR	Y1Q_0017512	A0A151NNF7	A0A151P277	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.488
AR	Y1Q_0017513	A0A151NNF7	A0A151P278	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1-like.	0.488
BMPR2	TMED2	A0A151N9A5	A0A151NRY5	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transmembrane emp24 domain-containing protein 2 isoform B.	0.523
FOSL1	JUNB	A0A151MZX8	A0A151NZQ2	Fos-related antigen 1.	Transcription factor jun-B.	0.889
GHRL-1	GHSR	A0A151MK48	A0A151M6E9	Appetite-regulating hormone isoform B.	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.998
GHRL-1	OXT	A0A151MK48	A0A151MY84	Appetite-regulating hormone isoform B.	Neurophysin 1; Belongs to the vasopressin/oxytocin family.	0.485
GHRL-1	Y1Q_0015648	A0A151MK48	A0A151NNI3	Appetite-regulating hormone isoform B.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.995
GHSR	GHRL-1	A0A151M6E9	A0A151MK48	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	Appetite-regulating hormone isoform B.	0.998
GHSR	Y1Q_0015648	A0A151M6E9	A0A151NNI3	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.902
HPGD	HSD11B2	A0A151PB84	A0A151NDE2	15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Corticosteroid 11-beta-dehydrogenase isozyme 2 isoform A.	0.618
HSD11B2	HPGD	A0A151NDE2	A0A151PB84	Corticosteroid 11-beta-dehydrogenase isozyme 2 isoform A.	15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.618
IRG1	Y1Q_0007360	A0A151NKW0	A0A151P7P3	Cis-aconitate decarboxylase.	Uncharacterized protein.	0.902
ITGB3-2	ITGB4	A0A151PBV2	A0A151N3K7	Integrin beta; Belongs to the integrin beta chain family.	Integrin beta.	0.664
ITGB4	ITGB3-2	A0A151N3K7	A0A151PBV2	Integrin beta.	Integrin beta; Belongs to the integrin beta chain family.	0.664
ITGB4	MMP9	A0A151N3K7	A0A151MM81	Integrin beta.	Uncharacterized protein.	0.414
JUNB	FOSL1	A0A151NZQ2	A0A151MZX8	Transcription factor jun-B.	Fos-related antigen 1.	0.889
MED1	AR	A0A151P5B9	A0A151NNF7	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Androgen receptor.	0.488
MED1	MED1-2	A0A151P5B9	A0A151P5D7	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.947