50 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RARRES2	Retinoic acid receptor responder protein 2. (156 aa)
	Y1Q_0010680	Uncharacterized protein. (176 aa)
	CARM1	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (458 aa)
	TPH1	Uncharacterized protein. (482 aa)
	Y1Q_0024399	Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	Y1Q_0024403	Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A. (1011 aa)
	HTR2A	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	PTGS2	Prostaglandin G/H synthase 2. (605 aa)
	FNDC5	Fibronectin type III domain-containing protein 5. (225 aa)
	ASXL3	Putative Polycomb group protein ASXL3. (942 aa)
	MEDAG-1	Mesenteric estrogen-dependent adipogenesis protein isoform C. (313 aa)
	ASXL2-1	Putative Polycomb group protein ASXL2 isoform B. (1144 aa)
	ADIRF	Adipogenesis regulatory factor. (76 aa)
	Y1Q_0015232	UBA_6 domain-containing protein. (145 aa)
	ZBTB7C	Zinc finger and BTB domain-containing protein 7C. (663 aa)
	STK4	Serine/threonine-protein kinase 4. (490 aa)
	SYAP1	Synapse-associated protein 1. (312 aa)
	Y1Q_0014316	Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	SAV1	Salvador-like protein 1. (391 aa)
	AAMDC	Mth938 domain-containing protein. (135 aa)
	CREB1	Cyclic AMP-responsive element-binding protein 1. (327 aa)
	SOX13	Transcription factor SOX-13. (643 aa)
	WDFY2-2	Uncharacterized protein. (400 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (389 aa)
	RREB1	Ras-responsive element-binding protein 1 isoform B. (1726 aa)
	NOCT	Nocturnin. (420 aa)
	KLF5	Krueppel-like factor 5. (365 aa)
	XBP1	X-box-binding protein 1. (286 aa)
	CCDC71L-1	Coiled-coil domain-containing protein 71L isoform B. (79 aa)
	NAPEPLD	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D. (413 aa)
	CMKLR1	Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	CARM1-2	CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (548 aa)
	METRNL	Meteorin-like protein. (292 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (357 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
	CEBPB	CCAAT/enhancer-binding protein beta. (141 aa)
	ZBTB7B	Zinc finger and BTB domain-containing protein 7B. (485 aa)
	STK4-2	Protein kinase domain-containing protein. (416 aa)
	Y1Q_0002793	SARAH domain-containing protein. (108 aa)
	FFAR4	Free fatty acid receptor 4. (353 aa)
	VSTM2A-1	V-set and transmembrane domain-containing protein 2A isoform A. (240 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16. (666 aa)
	KLF8L	Krueppel-like factor 5. (451 aa)
	CREBL2	cAMP-responsive element-binding protein-like 2 isoform B. (139 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	WIF1	Wnt inhibitory factor 1. (377 aa)
	TMEM64	Transmembrane protein 64 isoform A. (566 aa)
	Y1Q_0010122	Uncharacterized protein. (300 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (453 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIRF	SIRT6	A0A151MTB9	A0A151NX83	Adipogenesis regulatory factor.	NAD-dependent protein deacetylase sirtuin-6.	0.410
CEBPB	CREB1	A0A151NYY9	A0A151N9K7	CCAAT/enhancer-binding protein beta.	Cyclic AMP-responsive element-binding protein 1.	0.632
CEBPB	KLF5	A0A151NYY9	A0A151NL62	CCAAT/enhancer-binding protein beta.	Krueppel-like factor 5.	0.693
CEBPB	KLF8L	A0A151NYY9	A0A151P7J3	CCAAT/enhancer-binding protein beta.	Krueppel-like factor 5.	0.588
CEBPB	PPARG	A0A151NYY9	A0A151PJ63	CCAAT/enhancer-binding protein beta.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.792
CREB1	CEBPB	A0A151N9K7	A0A151NYY9	Cyclic AMP-responsive element-binding protein 1.	CCAAT/enhancer-binding protein beta.	0.632
FNDC3A	Y1Q_0010680	A0A151MGC8	A0A151M6H1	Fibronectin type-III domain-containing protein 3A.	Uncharacterized protein.	0.908
HTR2A	TPH1	A0A151MHJ2	A0A151MC75	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.542
KLF5	CEBPB	A0A151NL62	A0A151NYY9	Krueppel-like factor 5.	CCAAT/enhancer-binding protein beta.	0.693
KLF5	PPARG	A0A151NL62	A0A151PJ63	Krueppel-like factor 5.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.517
KLF8L	CEBPB	A0A151P7J3	A0A151NYY9	Krueppel-like factor 5.	CCAAT/enhancer-binding protein beta.	0.588
KLF8L	PPARG	A0A151P7J3	A0A151PJ63	Krueppel-like factor 5.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.517
LRP5	SFRP2	A0A151NXF3	A0A151PB47	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Secreted frizzled-related protein 2.	0.478
LRP5	WIF1	A0A151NXF3	A0A151PF32	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Wnt inhibitory factor 1.	0.489
PPARG	CEBPB	A0A151PJ63	A0A151NYY9	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	CCAAT/enhancer-binding protein beta.	0.792
PPARG	KLF5	A0A151PJ63	A0A151NL62	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Krueppel-like factor 5.	0.517
PPARG	KLF8L	A0A151PJ63	A0A151P7J3	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Krueppel-like factor 5.	0.517
PPARG	PTGS2	A0A151PJ63	A0A151MIJ3	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Prostaglandin G/H synthase 2.	0.401
PTGS2	PPARG	A0A151MIJ3	A0A151PJ63	Prostaglandin G/H synthase 2.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.401
SAV1	STK4	A0A151N3H9	A0A151MY95	Salvador-like protein 1.	Serine/threonine-protein kinase 4.	0.931