STRINGSTRING
ACVR2A ACVR2A SMAD2 SMAD2 JAG1-2 JAG1-2 Y1Q_0002384 Y1Q_0002384 TP63 TP63 CEBPD CEBPD IL6 IL6 BMPR1A-2 BMPR1A-2 IL6ST IL6ST CTHRC1 CTHRC1 ILK ILK FAM20C-2 FAM20C-2 BMPR2 BMPR2 WWTR1 WWTR1 BMP7 BMP7 CYR61 CYR61 WDR63 WDR63 ATRAID ATRAID BMPR1A BMPR1A SUCO-1 SUCO-1 Y1Q_0020183 Y1Q_0020183 DDR2-2 DDR2-2 LRP5 LRP5 CEBPB CEBPB ZHX3 ZHX3 FFAR4 FFAR4 ACVR1-2 ACVR1-2 GLI3 GLI3 CTNNB1 CTNNB1 YAP1 YAP1 SFRP2 SFRP2 SMAD1 SMAD1 ACVR2B ACVR2B BMP4 BMP4 GDPD2 GDPD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (498 aa)
SMAD2Mothers against decapentaplegic homolog. (474 aa)
JAG1-2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1147 aa)
Y1Q_0002384TGFb_propeptide domain-containing protein. (154 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
CEBPDCCAAT/enhancer-binding protein delta. (124 aa)
IL6Interleukin-6. (178 aa)
BMPR1A-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (600 aa)
IL6STInterleukin-6 receptor subunit beta. (854 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (239 aa)
ILKIntegrin-linked protein kinase. (452 aa)
FAM20C-2Fam20C domain-containing protein. (550 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
WWTR1WW domain-containing transcription regulator protein 1. (272 aa)
BMP7Bone morphogenetic protein 7. (416 aa)
CYR61Protein CYR61. (374 aa)
WDR63WD repeat-containing protein 63. (867 aa)
ATRAIDAll-trans retinoic acid-induced differentiation factor. (213 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SUCO-1SUN domain-containing ossification factor isoform A; Belongs to the tumor necrosis factor family. (1247 aa)
Y1Q_0020183PDZ and LIM domain protein 7. (272 aa)
DDR2-2Uncharacterized protein. (857 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
CEBPBCCAAT/enhancer-binding protein beta. (141 aa)
ZHX3Zinc fingers and homeoboxes protein 3. (932 aa)
FFAR4Free fatty acid receptor 4. (353 aa)
ACVR1-2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
GLI3Uncharacterized protein. (1572 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
YAP1Transcriptional coactivator YAP1 isoform A. (432 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP4Bone morphogenetic protein 4. (348 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2. (523 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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