STRINGSTRING
MST1 MST1 TGFB1 TGFB1 DDIT4 DDIT4 SIRT6 SIRT6 SOGA1 SOGA1 LEPR-1 LEPR-1 CRY1 CRY1 Y1Q_0024039 Y1Q_0024039 CREBBP CREBBP CLTC CLTC FAM132A FAM132A COX11 COX11 FLCN FLCN AP2A2 AP2A2 MIDN MIDN TP53 TP53 MIDNL MIDNL SMPD3 SMPD3 CLTCL1 CLTCL1 INPP5K INPP5K PASK PASK PLEK PLEK ADIPOQ ADIPOQ PARK2L PARK2L PARK2 PARK2 FAM3A FAM3A FAM3C FAM3C STAT4 STAT4 Y1Q_0015122 Y1Q_0015122 PPARAB PPARAB TIGAR TIGAR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
DDIT4DNA damage-inducible transcript 4 protein. (172 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
SOGA1Protein SOGA1 isoform A. (1537 aa)
LEPR-1Leptin receptor isoform B. (528 aa)
CRY1Cryptochrome 4. (665 aa)
Y1Q_0024039KIX domain-containing protein. (131 aa)
CREBBPCREB-binding protein isoform C. (2208 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1744 aa)
FAM132AAdipolin. (569 aa)
COX11Cytochrome c oxidase assembly protein COX11, mitochondrial. (171 aa)
FLCNFolliculin. (629 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa)
MIDNMidnolin. (80 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
MIDNLMidnolin. (361 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (642 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1672 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform B. (472 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1329 aa)
PLEKPleckstrin. (352 aa)
ADIPOQAdiponectin. (263 aa)
PARK2LRBR-type E3 ubiquitin transferase. (180 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform A. (280 aa)
FAM3AProtein FAM3A. (232 aa)
FAM3CProtein FAM3C. (227 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
Y1Q_0015122Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (246 aa)
PPARABPeroxisome proliferator-activated receptor alpha. (438 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (272 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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