(63 nodes) Regulation of receptor-mediated endocytosis network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAP1	Stromal membrane-associated protein 1. (472 aa)
	GSG1	Germ cell-specific 1 protein isoform A. (372 aa)
	NEU3	Sialidase-3. (451 aa)
	LRRC1-2	Uncharacterized protein. (798 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	LRPAP1	Alpha-2-macroglobulin receptor-associated protein. (340 aa)
	WDR54	WD repeat-containing protein 54. (174 aa)
	RIN3	Ras and Rab interactor 3. (963 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (404 aa)
	APLN	Apelin. (70 aa)
	BMP2K	BMP-2-inducible protein kinase isoform B. (1003 aa)
	ATAD1	ATPase family AAA domain-containing protein 1; Belongs to the AAA ATPase family. (409 aa)
	SERPINE1	Serpin E3-like; Belongs to the serpin family. (527 aa)
	DKK1	Dickkopf-related protein 1. (103 aa)
	DRD4	D(4) dopamine receptor isoform A; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	EFNB2	Ephrin-B2; Belongs to the ephrin family. (333 aa)
	Y1Q_0014591	Uncharacterized protein. (95 aa)
	VTN	Vitronectin. (324 aa)
	UNC119	Unc-119-like protein A. (207 aa)
	NEU2	Sialidase-2. (423 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein isoform A. (1040 aa)
	ANKRD13A	Ankyrin repeat domain-containing protein 13A. (587 aa)
	ATXN2	Uncharacterized protein. (1620 aa)
	HIP1R-2	Uncharacterized protein. (1065 aa)
	MKLN1	Muskelin. (736 aa)
	MAGI2	Uncharacterized protein. (1393 aa)
	Y1Q_0023392	PDZ domain-containing protein. (102 aa)
	PICALM	Phosphatidylinositol-binding clathrin assembly protein isoform A. (669 aa)
	PICALM-2	ENTH domain-containing protein. (609 aa)
	CD63	Tetraspanin. (240 aa)
	GAK	Cyclin-G-associated kinase isoform A. (878 aa)
	SGIP1	SH3-containing GRB2-like protein 3-interacting protein 1 isoform D. (861 aa)
	PICK1	PRKCA-binding protein isoform A. (428 aa)
	RSPO1	R-spondin-1. (260 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (435 aa)
	Y1Q_0002505	Uncharacterized protein. (135 aa)
	ITGAV-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
	ANKRD13B	ANK_REP_REGION domain-containing protein. (332 aa)
	CCL21	SCY domain-containing protein. (93 aa)
	FMR1-2	Uncharacterized protein. (761 aa)
	CLU	Clusterin; Belongs to the clusterin family. (467 aa)
	RABGEF1	Rab5 GDP/GTP exchange factor isoform C. (554 aa)
	USH1G	Usher syndrome type-1G protein. (468 aa)
	TNK2	Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	LRRTM1	Leucine-rich repeat transmembrane neuronal protein 1. (455 aa)
	LRRC1	Leucine-rich repeat-containing protein 1 isoform G. (1689 aa)
	Y1Q_0011409	Basic proline-rich protein-like. (131 aa)
	GREM1	Gremlin-1. (216 aa)
	ANKRD13D	ANK_REP_REGION domain-containing protein. (610 aa)
	SNAP91	Clathrin coat assembly protein AP180 isoform A. (857 aa)
	TBC1D5	TBC1 domain family member 5. (775 aa)
	BMP2K-2	Protein kinase domain-containing protein. (1055 aa)
	DTNBP1	Dysbindin. (352 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (266 aa)
	LDLRAP1	Low density lipoprotein receptor adapter protein 1. (302 aa)
	VEGFA-1	Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
	PPP3R1	Calcineurin subunit B type 1. (170 aa)
	SYNJ1	PAX3-and PAX7-binding protein 1. (2276 aa)
	SYK-2	Tyrosine-protein kinase. (608 aa)
	ADIPOQ	Adiponectin. (263 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (882 aa)
	AHI1	Jouberin isoform A. (1231 aa)
	SCYL2	SCY1-like protein 2 isoform A. (991 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	SERPINE1	A0A151M626	A0A151P049	Adiponectin.	Serpin E3-like; Belongs to the serpin family.	0.470
ARC	FMR1-2	A0A151P8B8	A0A151N7M5	Activity-regulated cytoskeleton-associated protein.	Uncharacterized protein.	0.406
ATXN2	FMR1-2	A0A151NSD3	A0A151N7M5	Uncharacterized protein.	Uncharacterized protein.	0.593
ATXN2	GAK	A0A151NSD3	A0A151NJE3	Uncharacterized protein.	Cyclin-G-associated kinase isoform A.	0.584
ATXN2	SYNJ1	A0A151NSD3	A0A151ME17	Uncharacterized protein.	PAX3-and PAX7-binding protein 1.	0.545
BMP2K	GAK	A0A151P509	A0A151NJE3	BMP-2-inducible protein kinase isoform B.	Cyclin-G-associated kinase isoform A.	0.791
BMP2K	HIP1R	A0A151P509	A0A151NTK3	BMP-2-inducible protein kinase isoform B.	Huntingtin-interacting protein 1-related protein isoform A.	0.604
BMP2K	HIP1R-2	A0A151P509	A0A151NSB7	BMP-2-inducible protein kinase isoform B.	Uncharacterized protein.	0.630
BMP2K	PICALM	A0A151P509	A0A151NNA6	BMP-2-inducible protein kinase isoform B.	Phosphatidylinositol-binding clathrin assembly protein isoform A.	0.636
BMP2K	PICALM-2	A0A151P509	A0A151NMC7	BMP-2-inducible protein kinase isoform B.	ENTH domain-containing protein.	0.609
BMP2K	SGIP1	A0A151P509	A0A151NJD5	BMP-2-inducible protein kinase isoform B.	SH3-containing GRB2-like protein 3-interacting protein 1 isoform D.	0.567
BMP2K	SNAP91	A0A151P509	A0A151MTY6	BMP-2-inducible protein kinase isoform B.	Clathrin coat assembly protein AP180 isoform A.	0.609
BMP2K-2	GAK	A0A151MQ01	A0A151NJE3	Protein kinase domain-containing protein.	Cyclin-G-associated kinase isoform A.	0.791
BMP2K-2	HIP1R	A0A151MQ01	A0A151NTK3	Protein kinase domain-containing protein.	Huntingtin-interacting protein 1-related protein isoform A.	0.604
BMP2K-2	HIP1R-2	A0A151MQ01	A0A151NSB7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.604
BMP2K-2	PICALM	A0A151MQ01	A0A151NNA6	Protein kinase domain-containing protein.	Phosphatidylinositol-binding clathrin assembly protein isoform A.	0.582
BMP2K-2	PICALM-2	A0A151MQ01	A0A151NMC7	Protein kinase domain-containing protein.	ENTH domain-containing protein.	0.582
BMP2K-2	SGIP1	A0A151MQ01	A0A151NJD5	Protein kinase domain-containing protein.	SH3-containing GRB2-like protein 3-interacting protein 1 isoform D.	0.459
BMP2K-2	SNAP91	A0A151MQ01	A0A151MTY6	Protein kinase domain-containing protein.	Clathrin coat assembly protein AP180 isoform A.	0.582
CLUL1	VTN	A0A151NEK0	A0A151NVP9	Clusterin; Belongs to the clusterin family.	Vitronectin.	0.548