(49 nodes) NADP binding network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	ME1	Malic enzyme. (574 aa)
	TP53I3	Quinone oxidoreductase PIG3. (340 aa)
	DHFR	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (173 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (914 aa)
	SNAPC2L	Dimethylaniline monooxygenase [N-oxide-forming]. (550 aa)
	DECR1	2,4-dienoyl-CoA reductase, mitochondrial. (336 aa)
	CBR4	Carbonyl reductase family member 4. (237 aa)
	QDPR	Dihydropteridine reductase. (242 aa)
	Y1Q_0016689	Uncharacterized protein. (94 aa)
	NOS2	Nitric oxide synthase, inducible. (877 aa)
	LBR	Lamin-B receptor. (597 aa)
	Y1Q_0007230	NOS domain-containing protein. (211 aa)
	ASPDH	Putative L-aspartate dehydrogenase. (299 aa)
	FMO1	Flavin-containing monooxygenase. (636 aa)
	FMO5	Flavin-containing monooxygenase. (464 aa)
	Y1Q_0006679	Flavin-containing monooxygenase. (446 aa)
	PLPP6-2	Flavin-containing monooxygenase. (479 aa)
	Y1Q_0006677	Flavin-containing monooxygenase. (132 aa)
	Y1Q_0006678	Flavin-containing monooxygenase. (126 aa)
	ME3	Malic enzyme. (573 aa)
	CRYZ	Quinone oxidoreductase. (367 aa)
	GMDS	GDP-mannose 4,6 dehydratase. (353 aa)
	Y1Q_0008000	Glyoxylate/hydroxypyruvate reductase B-like. (694 aa)
	GRHPR	Glyoxylate reductase/hydroxypyruvate reductase. (618 aa)
	MTRR	Methionine synthase reductase. (704 aa)
	HSD17B1	Estradiol 17-beta-dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (295 aa)
	GLYR1	Putative oxidoreductase GLYR1. (565 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (657 aa)
	NOS2-2	Nitric oxide synthase; Produces nitric oxide (NO). (1120 aa)
	NOS1	Uncharacterized protein. (1441 aa)
	Y1Q_0022796	Uncharacterized protein. (109 aa)
	Y1Q_0022798	Hydroxysteroid 11-beta-dehydrogenase 1-like protein A. (105 aa)
	H6PD	GDH/6PGL endoplasmic bifunctional protein. (715 aa)
	PGD	6-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (637 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (463 aa)
	CRYM	Ketimine reductase mu-crystallin. (314 aa)
	TM7SF2	Delta(14)-sterol reductase. (418 aa)
	DUS2	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like. (525 aa)
	HIBADH	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (328 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (545 aa)
	HSD11B1	Corticosteroid 11-beta-dehydrogenase isozyme 1. (317 aa)
	FMO2	Flavin-containing monooxygenase. (431 aa)
	FMO3	Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
	NDOR1	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (615 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	DHCR7	7-dehydrocholesterol reductase isoform A. (392 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
	Y1Q_0005850	Glyceraldehyde-3-phosphate dehydrogenase. (394 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT	G6PD	A0A151MBG0	A0A151MQ94	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.416
CAT	GSR	A0A151MBG0	A0A151N359	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.767
CAT	H6PD	A0A151MBG0	A0A151N3W0	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	GDH/6PGL endoplasmic bifunctional protein.	0.649
CAT	HMGCR	A0A151MBG0	A0A151PHL8	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.542
CAT	MTRR	A0A151MBG0	A0A151ND40	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Methionine synthase reductase.	0.452
CAT	NDOR1	A0A151MBG0	A0A151MEU1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.445
CAT	NOS1	A0A151MBG0	A0A151N582	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.452
CAT	NOS2	A0A151MBG0	A0A151P443	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase, inducible.	0.452
CAT	NOS2-2	A0A151MBG0	A0A151N5R3	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Nitric oxide synthase; Produces nitric oxide (NO).	0.452
CAT	POR	A0A151MBG0	A0A151N603	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.452
CAT	Y1Q_0007230	A0A151MBG0	A0A151P2S1	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	NOS domain-containing protein.	0.452
CBR4	H6PD	A0A151PB60	A0A151N3W0	Carbonyl reductase family member 4.	GDH/6PGL endoplasmic bifunctional protein.	0.411
CRYM	CRYZ	A0A151N1U1	A0A151NJ71	Ketimine reductase mu-crystallin.	Quinone oxidoreductase.	0.521
CRYZ	CRYM	A0A151NJ71	A0A151N1U1	Quinone oxidoreductase.	Ketimine reductase mu-crystallin.	0.521
CRYZ	H6PD	A0A151NJ71	A0A151N3W0	Quinone oxidoreductase.	GDH/6PGL endoplasmic bifunctional protein.	0.408
DHCR7	HMGCR	A0A151MBL2	A0A151PHL8	7-dehydrocholesterol reductase isoform A.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.684
DHFR	DPYD	A0A151PHR9	A0A151M4W2	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.412
DHFR	GAPDH	A0A151PHR9	A0A151MCM1	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.531
DHFR	GRHPR	A0A151PHR9	A0A151NDW1	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Glyoxylate reductase/hydroxypyruvate reductase.	0.582
DHFR	GSR	A0A151PHR9	A0A151N359	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.621