STRINGSTRING
AR AR c-jun c-jun Y1Q_0020256 Y1Q_0020256 AGGF1 AGGF1 TGFBR1 TGFBR1 JUND JUND AMICA1 AMICA1 CAV2 CAV2 WNT2 WNT2 FGF2 FGF2 BMP4 BMP4 Y1Q_0014445 Y1Q_0014445 STAT4 STAT4 GRN-1 GRN-1 ITGB3-2 ITGB3-2 VEGFC VEGFC KDR KDR MYC MYC MED1-2 MED1-2 MED1 MED1 TGFA TGFA SP1 SP1 RPTOR RPTOR VASH2 VASH2 HLX-1 HLX-1 CTNNB1 CTNNB1 Y1Q_0017513 Y1Q_0017513 Y1Q_0017512 Y1Q_0017512 SIRT1 SIRT1 MYDGF MYDGF SIRT6 SIRT6 APLNR APLNR TNF TNF SMO SMO VIP VIP XBP1 XBP1 Y1Q_0017259 Y1Q_0017259 ST8SIA1-1 ST8SIA1-1 PTN PTN PDGFB PDGFB RREB1 RREB1 GPR25L GPR25L BMP7 BMP7 PKHD1 PKHD1 SCG2 SCG2 PROK1 PROK1 BMPR2 BMPR2 ADAM17 ADAM17 NF1 NF1 EPGN EPGN PIK3CD PIK3CD STXBP4 STXBP4 FIGF FIGF OSR2-1 OSR2-1 WNT2B WNT2B MST1 MST1 PDX1 PDX1 ESRP2-2 ESRP2-2 ACVR1 ACVR1 DLX5 DLX5 HPN HPN CYP7B1 CYP7B1 TP63 TP63 CLDN1 CLDN1 PGF-1 PGF-1 PROK2 PROK2 VEGFA-1 VEGFA-1 Y1Q_0002384 Y1Q_0002384 LRG1 LRG1 IGF2-1 IGF2-1 MDK MDK IL10 IL10 ECM1 ECM1 FGF7-2 FGF7-2 MAP2K5 MAP2K5 GAS1 GAS1 CRNN CRNN FLT1 FLT1 FGF1-1 FGF1-1 NKX2-5 NKX2-5 EMC10 EMC10 Y1Q_0016277 Y1Q_0016277 TNFAIP3 TNFAIP3 ITGA4 ITGA4 NR4A1 NR4A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARAndrogen receptor. (634 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
Y1Q_0020256Uncharacterized protein. (236 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1 isoform A. (673 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
JUNDBZIP domain-containing protein. (87 aa)
AMICA1Junctional adhesion molecule-like. (277 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
BMP4Bone morphogenetic protein 4. (348 aa)
Y1Q_0014445Junctional protein associated with coronary artery disease. (1337 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
GRN-1Granulins isoform B. (1084 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1353 aa)
MYCMyc proto-oncogene protein. (169 aa)
MED1-2Uncharacterized protein. (259 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1104 aa)
TGFAProtransforming growth factor alpha. (159 aa)
SP1Transcription factor Sp1. (746 aa)
RPTORRegulatory-associated protein of mTOR isoform A. (1352 aa)
VASH2Vasohibin-2. (290 aa)
HLX-1H2.0-like homeobox protein isoform A. (362 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
Y1Q_0017513Mediator of RNA polymerase II transcription subunit 1-like. (204 aa)
Y1Q_0017512Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (345 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
MYDGFMyeloid-derived growth factor. (124 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
TNFTumor necrosis factor. (231 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (804 aa)
VIPVIP peptides. (234 aa)
XBP1X-box-binding protein 1. (286 aa)
Y1Q_0017259Myc_N domain-containing protein. (77 aa)
ST8SIA1-1Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform A; Belongs to the glycosyltransferase 29 family. (381 aa)
PTNPleiotrophin. (165 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
RREB1Ras-responsive element-binding protein 1 isoform B. (1726 aa)
GPR25LApelin receptor A-like isoform A; Belongs to the G-protein coupled receptor 1 family. (329 aa)
BMP7Bone morphogenetic protein 7. (416 aa)
PKHD1Fibrocystin isoform B. (4049 aa)
SCG2Secretogranin-2. (681 aa)
PROK1Prokineticin-1. (223 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
NF1Neurofibromin isoform B. (2879 aa)
EPGNEpigen isoform B. (150 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1030 aa)
STXBP4Syntaxin-binding protein 4. (681 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
OSR2-1Protein odd-skipped-related 2 isoform A. (281 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
PDX1Pancreas/duodenum homeobox protein 1. (206 aa)
ESRP2-2RRM domain-containing protein. (732 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
DLX5Homeobox protein DLX-5. (266 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (424 aa)
CYP7B125-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
PGF-1Placenta growth factor isoform A; Belongs to the PDGF/VEGF growth factor family. (219 aa)
PROK2Prokineticin-2. (72 aa)
VEGFA-1Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
Y1Q_0002384TGFb_propeptide domain-containing protein. (154 aa)
LRG1Leucine-rich alpha-2-glycoprotein. (406 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
MDKMidkine. (156 aa)
IL10Interleukin-10. (93 aa)
ECM1Extracellular matrix protein 1. (420 aa)
FGF7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (446 aa)
GAS1Growth arrest-specific protein 1. (113 aa)
CRNNCornulin. (456 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1725 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NKX2-5Homeobox protein Nkx-2.5. (257 aa)
EMC10ER membrane protein complex subunit 10 isoform B. (283 aa)
Y1Q_0016277Uncharacterized protein. (377 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (853 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1036 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (579 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.