STRINGSTRING
ABI2 ABI2 ERRFI1 ERRFI1 GPRC5A GPRC5A Y1Q_0011722 Y1Q_0011722 PARP14 PARP14 PARP9 PARP9 CADM4 CADM4 FGFR1OP-1 FGFR1OP-1 AGT AGT IL22RA2 IL22RA2 PLPP3 PLPP3 CD74 CD74 KIT KIT HRG HRG SYK-2 SYK-2 SEMA4D SEMA4D LRRK1 LRRK1 FGF7-2 FGF7-2 FREM3-2 FREM3-2 IL34L IL34L IL19 IL19 FAM72A FAM72A TSG101 TSG101 IGF2-1 IGF2-1 PTPN6 PTPN6 TNFRSF1A TNFRSF1A SH2D1B SH2D1B CBLB-2 CBLB-2 SAMSN1-1 SAMSN1-1 APP APP SPINK1 SPINK1 IL11 IL11 VEGFA-1 VEGFA-1 HTR2A HTR2A STAP1 STAP1 CD24 CD24 PAK2-2 PAK2-2 GHRL-1 GHRL-1 CAV3 CAV3 ERCC6 ERCC6 RIPK3L RIPK3L SH3BP5L SH3BP5L IL7 IL7 LYN LYN IL6 IL6 ARL2BP ARL2BP SH3BP5 SH3BP5 ITGA5 ITGA5 EFNA1 EFNA1 IBTK IBTK CLCF1 CLCF1 GATA1 GATA1 GNB2L1 GNB2L1 GREM1 GREM1 LTK-2 LTK-2 NOX4 NOX4 CD40 CD40 TP53 TP53 RICTOR RICTOR Y1Q_0009901 Y1Q_0009901 IL6ST IL6ST ENPP2 ENPP2 ANGPT2-2 ANGPT2-2 TNK2 TNK2 ZGPAT ZGPAT NEDD9 NEDD9 SOCS1 SOCS1 PECAM1-1 PECAM1-1 MILR1 MILR1 SOCS4 SOCS4 Y1Q_0006015 Y1Q_0006015 MTOR MTOR LIF LIF NF2 NF2 BTC BTC EREG EREG EPGN EPGN Y1Q_0007089 Y1Q_0007089 ZZEF1 ZZEF1 FBXW9 FBXW9 FAM150B FAM150B ADAM17 ADAM17 FBXW7 FBXW7 IL12A IL12A DMTN DMTN Y1Q_0018553 Y1Q_0018553 PTPRC PTPRC BMP7 BMP7 IL23A IL23A DGKQ DGKQ NRG1-1 NRG1-1 PTPN2 PTPN2 Y1Q_0010174 Y1Q_0010174 HPX HPX IL18 IL18 CBLB CBLB IL15-1 IL15-1 PDGFB PDGFB ZC3HAV1L ZC3HAV1L IL34 IL34 PIBF1 PIBF1 BANK1 BANK1 NPM3 NPM3 RELN RELN HGF HGF HBEGF-1 HBEGF-1 NRG2-2 NRG2-2 NRG2 NRG2 SH2B3 SH2B3 INPP5F INPP5F NEURL1 NEURL1 CNTF CNTF UNC119 UNC119 VTN VTN MLST8 MLST8 SOCS3 SOCS3 GAS6 GAS6 ARHGEF1A ARHGEF1A ADNP ADNP PTPN1 PTPN1 CASS4 CASS4 HOMER3L HOMER3L CRLF1 CRLF1 ANGPT2-1 ANGPT2-1 LTK LTK CHMP6 CHMP6 TGFA TGFA CSF3 CSF3 SRCIN1 SRCIN1 ADRA1A ADRA1A Y1Q_0011001 Y1Q_0011001 PDGFD PDGFD FGFR3 FGFR3 DOK7-1 DOK7-1 ZFYVE28 ZFYVE28 BST1-1 BST1-1 CNOT7 CNOT7 KIT-2 KIT-2 PDGFC PDGFC SFRP2 SFRP2 FBXW7-2 FBXW7-2 VPS25 VPS25 ITGB3-2 ITGB3-2 NCAPG2 NCAPG2 NRP2 NRP2 CAV1 CAV1 IFNG IFNG MXD3 MXD3 IL6RA IL6RA RIPK2 RIPK2 EFNA5 EFNA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABI2Abl interactor 2. (463 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (453 aa)
GPRC5ARetinoic acid-induced protein 3. (391 aa)
Y1Q_0011722Poly [ADP-ribose] polymerase. (1246 aa)
PARP14Poly [ADP-ribose] polymerase. (1614 aa)
PARP9Poly [ADP-ribose] polymerase 9. (823 aa)
CADM4Cell adhesion molecule 4. (428 aa)
FGFR1OP-1FGFR1 oncogene partner isoform A. (397 aa)
AGTAngiotensinogen; Belongs to the serpin family. (474 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2 isoform A. (238 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (314 aa)
CD74HLA class II histocompatibility antigen gamma chain; Belongs to the universal ribosomal protein uS11 family. (513 aa)
KITMast/stem cell growth factor receptor Kit isoform B; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
HRGHistidine-rich glycoprotein. (428 aa)
SYK-2Tyrosine-protein kinase. (608 aa)
SEMA4DSemaphorin-4D; Belongs to the semaphorin family. (856 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1 isoform A. (2001 aa)
FGF7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
FREM3-2Chondroitin sulfate proteoglycan 4-like. (2381 aa)
IL34LInterleukin-20. (177 aa)
IL19Interleukin-20. (208 aa)
FAM72AProtein FAM72A. (146 aa)
TSG101Tumor susceptibility 101 protein. (392 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (412 aa)
SH2D1BSH2 domain-containing protein 1B. (138 aa)
CBLB-2Uncharacterized protein. (995 aa)
SAMSN1-1SAM domain-containing protein SAMSN-1 isoform C. (784 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (743 aa)
SPINK1Serine protease inhibitor Kazal-type 1. (84 aa)
IL11Interleukin-11. (182 aa)
VEGFA-1Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
STAP1Signal-transducing adaptor protein 1. (164 aa)
CD24CD24 molecule. (84 aa)
PAK2-2Non-specific serine/threonine protein kinase. (741 aa)
GHRL-1Appetite-regulating hormone isoform B. (145 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ERCC6DNA excision repair protein ERCC-6. (1491 aa)
RIPK3LReceptor-interacting serine/threonine-protein kinase 2. (564 aa)
SH3BP5LSH3 domain-binding protein 5-like. (366 aa)
IL7Interleukin 7. (175 aa)
LYNTyrosine-protein kinase. (562 aa)
IL6Interleukin-6. (178 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (158 aa)
SH3BP5SH3 domain-binding protein 5 isoform B. (432 aa)
ITGA5Integrin alpha-5. (671 aa)
EFNA1Ephrin-A1; Belongs to the ephrin family. (205 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (232 aa)
GATA1Erythroid transcription factor. (485 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
GREM1Gremlin-1. (216 aa)
LTK-2Tyrosine-protein kinase receptor. (1443 aa)
NOX4NADPH oxidase 4 isoform B. (628 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (300 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RICTORRapamycin-insensitive companion of mTOR. (1439 aa)
Y1Q_0009901Uncharacterized protein. (1418 aa)
IL6STInterleukin-6 receptor subunit beta. (854 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform A. (890 aa)
ANGPT2-2Angiopoietin-2. (498 aa)
TNK2Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
ZGPATZinc finger CCCH-type with G patch domain-containing protein. (543 aa)
NEDD9Enhancer of filamentation 1. (802 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
PECAM1-1Platelet endothelial cell adhesion molecule isoform A. (728 aa)
MILR1Allergin-1 isoform A. (337 aa)
SOCS4Suppressor of cytokine signaling 4. (321 aa)
Y1Q_0006015TNFR-Cys domain-containing protein. (85 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2538 aa)
LIFLeukemia inhibitory factor. (211 aa)
NF2Merlin isoform A. (593 aa)
BTCProbetacellulin. (170 aa)
EREGProepiregulin. (159 aa)
EPGNEpigen isoform B. (150 aa)
Y1Q_0007089FERM domain-containing protein. (665 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain-containing protein 1. (2904 aa)
FBXW9F-box/WD repeat-containing protein 9. (457 aa)
FAM150BProtein FAM150B. (124 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
FBXW7F-box/WD repeat-containing protein 7. (665 aa)
IL12AInterleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (144 aa)
DMTNDematin. (401 aa)
Y1Q_0018553Integrin alpha-5-like. (167 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
BMP7Bone morphogenetic protein 7. (416 aa)
IL23AInterleukin-23 subunit alpha. (126 aa)
DGKQDiacylglycerol kinase. (973 aa)
NRG1-1Pro-neuregulin-1, membrane-bound isoform C. (636 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (429 aa)
Y1Q_0010174UBA domain-containing protein. (189 aa)
HPXHemopexin. (460 aa)
IL18Interleukin-18. (239 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (526 aa)
IL15-1Interleukin; Belongs to the IL-15/IL-21 family. (196 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
ZC3HAV1LPoly [ADP-ribose] polymerase. (368 aa)
IL34Interleukin-34 isoform B. (247 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform B. (756 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform B. (788 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
RELNReelin. (3448 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (723 aa)
HBEGF-1Proheparin-binding EGF-like growth factor isoform B. (205 aa)
NRG2-2Uncharacterized protein. (261 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform D. (675 aa)
SH2B3SH2B adapter protein 3. (600 aa)
INPP5FPhosphatidylinositide phosphatase SAC2. (1108 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (555 aa)
CNTFCiliary neurotrophic factor. (194 aa)
UNC119Unc-119-like protein A. (207 aa)
VTNVitronectin. (324 aa)
MLST8Target of rapamycin complex subunit LST8. (403 aa)
SOCS3Suppressor of cytokine signaling 3. (196 aa)
GAS6Growth arrest-specific protein 6. (676 aa)
ARHGEF1ARho guanine nucleotide exchange factor 2 isoform B. (970 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1122 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CASS4Cas scaffolding protein family member 4. (860 aa)
HOMER3LHomer protein-like protein 3 isoform A; Belongs to the semaphorin family. (569 aa)
CRLF1Cytokine receptor-like factor 1 isoform B. (388 aa)
ANGPT2-1Angiopoietin-2. (495 aa)
LTKTyrosine-protein kinase receptor. (1425 aa)
CHMP6Charged multivesicular body protein 6. (187 aa)
TGFAProtransforming growth factor alpha. (159 aa)
CSF3Granulocyte colony-stimulating factor. (154 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1697 aa)
ADRA1AAlpha-1A adrenergic receptor. (335 aa)
Y1Q_0011001Suppressor of cytokine signaling 3-like. (189 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
FGFR3Fibroblast growth factor receptor. (837 aa)
DOK7-1Protein Dok-7 isoform C. (489 aa)
ZFYVE28Lateral signaling target 2-like protein. (961 aa)
BST1-1ADP-ribosyl cyclase 2 isoform C. (339 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (262 aa)
KIT-2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (947 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FBXW7-2Uncharacterized protein. (674 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (174 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
NCAPG2Condensin-2 complex subunit G2. (1146 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (925 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
MXD3Lateral signaling target 2-like protein. (583 aa)
IL6RAInterleukin-6 receptor subunit alpha. (443 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (561 aa)
EFNA5Ephrin-A5; Belongs to the ephrin family. (189 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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