(178 nodes) Synapse organization network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPRA	Receptor-type tyrosine-protein phosphatase alpha isoform A. (1898 aa)
	PALM-1	Paralemmin-1 isoform B. (406 aa)
	PTPRS	Uncharacterized protein. (1911 aa)
	Y1Q_0016916	Uncharacterized protein. (618 aa)
	DCTN1	Dynactin subunit 1 isoform B. (1257 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	TMEM108	Transmembrane protein 108. (130 aa)
	LRRTM4	Leucine-rich repeat transmembrane neuronal protein 4. (513 aa)
	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform A. (541 aa)
	ADD2	Beta-adducin. (745 aa)
	NLGN3	COesterase domain-containing protein. (610 aa)
	ITGA3-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1085 aa)
	Y1Q_0016618	Uncharacterized protein. (867 aa)
	NEFL	Neurofilament light polypeptide; Belongs to the intermediate filament family. (550 aa)
	LRRTM4-2	Uncharacterized protein. (518 aa)
	CACNB1-2	SH3 domain-containing protein. (646 aa)
	SNTA1	Alpha-1-syntrophin. (489 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	NLGN2	COesterase domain-containing protein. (826 aa)
	SHISA6	Shisa-6-like protein. (360 aa)
	CNTN5	Uncharacterized protein. (1100 aa)
	DLG1	Disks large-like protein 1 isoform D; Belongs to the MAGUK family. (1703 aa)
	LGMN	Legumain. (470 aa)
	DOK7-1	Protein Dok-7 isoform C. (489 aa)
	LGI3	Leucine-rich repeat LGI family member 3 isoform A. (545 aa)
	GABRA2	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
	GPM6A	Neuronal membrane glycoprotein M6-a isoform A. (293 aa)
	GLRB	Glycine receptor subunit beta isoform B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
	CACNB2	SH3 domain-containing protein. (612 aa)
	LRFN4	Ig-like domain-containing protein. (503 aa)
	LRFN5	Ig-like domain-containing protein. (736 aa)
	PDZRN3	E3 ubiquitin-protein ligase PDZRN3. (794 aa)
	PPFIA2	Uncharacterized protein. (123 aa)
	Y1Q_0019878	Uncharacterized protein. (1229 aa)
	Y1Q_0000001	COesterase domain-containing protein. (130 aa)
	DLGAP2	Disks large-associated protein 2 isoform C. (889 aa)
	HOMER1	Homer protein-like protein 1. (355 aa)
	EFNA5	Ephrin-A5; Belongs to the ephrin family. (189 aa)
	SNAPIN	SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (134 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (97 aa)
	BCAN	Brevican core protein isoform A. (1153 aa)
	CYFIP1-2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1289 aa)
	NLGN4X-2	COesterase domain-containing protein. (812 aa)
	EFNB2	Ephrin-B2; Belongs to the ephrin family. (333 aa)
	SEZ6L2	Uncharacterized protein. (670 aa)
	ARHGAP39	Rho GTPase-activating protein 39-like isoform A. (653 aa)
	NOS1AP	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform B. (697 aa)
	IL1RAPL1	TIR domain-containing protein. (213 aa)
	SLITRK6	SLIT and NTRK-like protein 6. (851 aa)
	DBN1	Drebrin. (729 aa)
	SEZ6	Seizure 6-like protein isoform A. (920 aa)
	FARP1	Uncharacterized protein. (1063 aa)
	Y1Q_0019911	Drebrin-like. (419 aa)
	PPFIA3	Uncharacterized protein. (503 aa)
	SEMA3E	Sema domain-containing protein; Belongs to the semaphorin family. (774 aa)
	RELN	Reelin. (3448 aa)
	PCLO	Protein piccolo isoform D. (659 aa)
	CNKSR2	Connector enhancer of kinase suppressor of ras 2 isoform A. (326 aa)
	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2. (2528 aa)
	Y1Q_0015683	PH domain-containing protein. (905 aa)
	PAK3	Non-specific serine/threonine protein kinase. (526 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (119 aa)
	Y1Q_0015577	Wiskott-Aldrich syndrome protein family member 3-like. (509 aa)
	RAB39B	Ras-related protein Rab-39B. (144 aa)
	IL1RAPL2	X-linked interleukin-1 receptor accessory protein-like 2 isoform A. (593 aa)
	DRP2-2	Uncharacterized protein. (911 aa)
	SPARCL1	SPARC-like protein 1. (694 aa)
	Y1Q_0014123	Uncharacterized protein. (1097 aa)
	Y1Q_0015245	Uncharacterized protein. (986 aa)
	SLITRK1-1	SLIT and NTRK-like protein 1 isoform B. (604 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains protein 1 isoform A. (1730 aa)
	ARHGAP39-2	Rho GTPase-activating protein 39. (992 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (464 aa)
	ADGRL2	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family. (1465 aa)
	Y1Q_0024298	Uncharacterized protein. (232 aa)
	ERC1-2	FIP-RBD domain-containing protein. (865 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
	KY	Kyphoscoliosis peptidase. (678 aa)
	PICK1	PRKCA-binding protein isoform A. (428 aa)
	Y1Q_0000159	Rho GTPase-activating protein 39-like. (178 aa)
	EPHB3	Ephrin type-B receptor 3 isoform B. (1003 aa)
	UNC13A	Unc-13-like protein A isoform B. (1779 aa)
	NPAS4	Neuronal PAS domain-containing protein 4. (483 aa)
	Y1Q_0024442	Unc-13-like protein A. (2195 aa)
	CBLN2	C1q domain-containing protein. (117 aa)
	MUSK	Muscle, skeletal receptor tyrosine-protein kinase. (898 aa)
	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha isoform B. (380 aa)
	Y1Q_0004744	Protein kinase domain-containing protein. (161 aa)
	DOCK10	Uncharacterized protein; Belongs to the DOCK family. (2202 aa)
	DIP2A-2	DMAP-interaction domain-containing protein. (1509 aa)
	ALS2	Alsin. (1647 aa)
	WASF2	Wiskott-Aldrich syndrome protein family member 2. (347 aa)
	PPFIA1	Liprin-alpha-1 isoform B. (1240 aa)
	DLG3	Uncharacterized protein; Belongs to the MAGUK family. (905 aa)
	Y1Q_0003445	Uncharacterized protein. (169 aa)
	Y1Q_0003447	Disks large 1 tumor suppressor protein-like. (80 aa)
	DLG2	Uncharacterized protein. (615 aa)
	AGRN	Agrin isoform C. (2031 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
	SDK2	Uncharacterized protein. (1668 aa)
	SDK1	Uncharacterized protein. (2113 aa)
	SLC6A1	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
	CNKSR2-2	Uncharacterized protein. (837 aa)
	Y1Q_0022425	Uncharacterized protein. (171 aa)
	C1QC	Complement C1q subcomponent subunit C. (264 aa)
	C1QB	Complement C1q subcomponent subunit B. (249 aa)
	CDC42	Cell division control 42-like protein. (235 aa)
	C1QA	Complement C1q subcomponent subunit A. (273 aa)
	EPHB2	Uncharacterized protein. (1003 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	ERC1	ELKS/Rab6-interacting/CAST family member 1 isoform B. (578 aa)
	Y1Q_0023148	Uncharacterized protein. (200 aa)
	KYL	Kyphoscoliosis peptidase. (749 aa)
	LRRTM1	Leucine-rich repeat transmembrane neuronal protein 1. (455 aa)
	SYBU	Syntabulin. (642 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (185 aa)
	DLG4	Uncharacterized protein; Belongs to the MAGUK family. (783 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
	FILIP1L	Filamin A-interacting protein 1-like. (910 aa)
	Y1Q_0017371	Uncharacterized protein. (172 aa)
	SNCG	Gamma-synuclein; Belongs to the synuclein family. (132 aa)
	WASF3	Wiskott-Aldrich syndrome protein family member 3 isoform B. (566 aa)
	CBLN1	Cerebellin-1. (192 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains protein 3-like. (1242 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains protein 2. (524 aa)
	COLQ-1	Acetylcholinesterase collagenic tail peptide isoform B. (508 aa)
	ADGRL3	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1378 aa)
	Y1Q_0002127	SUEL-type lectin domain-containing protein. (93 aa)
	REST	RE1-silencing transcription factor. (913 aa)
	Y1Q_0019411	COesterase domain-containing protein. (181 aa)
	PPFIBP2	Liprin-beta-2 isoform A. (1034 aa)
	Y1Q_0018528	Uncharacterized protein. (907 aa)
	IL1RAP-1	Interleukin-1 receptor accessory protein isoform B. (852 aa)
	NPTN	Neuroplastin. (270 aa)
	PDZRN3-2	Uncharacterized protein. (933 aa)
	PLXND1-2	Sema domain-containing protein. (1744 aa)
	GHRL-1	Appetite-regulating hormone isoform B. (145 aa)
	FBXO45	F-box/SPRY domain-containing protein 1. (255 aa)
	WASF1	Wiskott-Aldrich syndrome protein family member 1. (454 aa)
	TNN	Tenascin-N. (1357 aa)
	SHISA7	Protein shisa-7. (510 aa)
	Y1Q_0005813	Serine/threonine-protein kinase LMTK3-like. (610 aa)
	TSC1	Hamartin isoform B. (1115 aa)
	NTNG2	Netrin-G2 isoform B. (552 aa)
	ZDHHC12	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (254 aa)
	Y1Q_0005609	Uncharacterized protein. (1687 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (743 aa)
	CLSTN3-2	Uncharacterized protein. (980 aa)
	Y1Q_0002937	CortBP2 domain-containing protein. (251 aa)
	CACNB3	SH3 domain-containing protein. (479 aa)
	PPFIBP2-2	Uncharacterized protein. (972 aa)
	SHANK2-2	Uncharacterized protein. (1191 aa)
	PRMT3	Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (517 aa)
	CTTN	Src substrate protein p85 isoform A. (1779 aa)
	Y1Q_0000547	ANK_REP_REGION domain-containing protein. (435 aa)
	GPHN	Gephyrin. (1005 aa)
	CNTN2-2	Uncharacterized protein. (1032 aa)
	Y1Q_0003388	Uncharacterized protein. (1341 aa)
	RAB29	Ras-related protein Rab-7L1. (205 aa)
	SEZ6-2	Uncharacterized protein. (1014 aa)
	ADAM10	Disintegrin and metalloproteinase domain-containing protein 10. (748 aa)
	UNC13C	Uncharacterized protein. (386 aa)
	Y1Q_0001496	Unc-13-like protein C-like. (271 aa)
	CBLN4	C1q domain-containing protein. (181 aa)
	EPHB3-2	Uncharacterized protein. (979 aa)
	GABRA1	Gamma-aminobutyric acid receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
	Y1Q_0010673	COesterase domain-containing protein. (237 aa)
	NLGN4X	Neuroligin-4, X-linked isoform B. (533 aa)
	LAMB2	Uncharacterized protein. (1523 aa)
	Y1Q_0015214	Uncharacterized protein. (749 aa)
	NTNG1	Netrin-G1. (458 aa)
	PAK2	Non-specific serine/threonine protein kinase. (546 aa)
	SYNPO	Synaptopodin. (1109 aa)
	GNPAT	Dihydroxyacetone phosphate acyltransferase. (671 aa)
	CACNB1	Voltage-dependent L-type calcium channel subunit beta-1 isoform A. (486 aa)
	TANC1	Protein TANC1 isoform A. (1496 aa)
	PRRT1	Proline-rich transmembrane protein 1. (112 aa)
	DBNL	Drebrin-like protein isoform B. (481 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	APP	A0A151MAB5	A0A151MDY4	Disintegrin and metalloproteinase domain-containing protein 10.	BPTI/Kunitz inhibitor domain-containing protein.	0.639
ADGRL2	CACNG2	A0A151NJE8	A0A151NHV4	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.595
ADGRL2	CACNG4	A0A151NJE8	A0A151N2A9	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.595
ADGRL2	LRFN4	A0A151NJE8	A0A151PCH3	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Ig-like domain-containing protein.	0.686
ADGRL2	LRFN5	A0A151NJE8	A0A151PDX0	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Ig-like domain-containing protein.	0.686
ADGRL2	LRRK2	A0A151NJE8	A0A151NP48	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat serine/threonine-protein kinase 2.	0.686
ADGRL2	LRRTM1	A0A151NJE8	A0A151MYL5	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat transmembrane neuronal protein 1.	0.688
ADGRL2	LRRTM4	A0A151NJE8	A0A151P406	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat transmembrane neuronal protein 4.	0.705
ADGRL2	LRRTM4-2	A0A151NJE8	A0A151P5Z5	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.706
ADGRL2	SLITRK1-1	A0A151NJE8	A0A151NKY5	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK-like protein 1 isoform B.	0.690
ADGRL2	SLITRK6	A0A151NJE8	A0A151NTG8	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK-like protein 6.	0.686
ADGRL2	Y1Q_0017371	A0A151NJE8	A0A151MTI2	Adhesion G protein-coupled receptor L2 isoform E; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.706
ADGRL3	CACNG2	A0A151MPZ2	A0A151NHV4	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.595
ADGRL3	CACNG4	A0A151MPZ2	A0A151N2A9	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.595
ADGRL3	LRFN4	A0A151MPZ2	A0A151PCH3	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Ig-like domain-containing protein.	0.686
ADGRL3	LRFN5	A0A151MPZ2	A0A151PDX0	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Ig-like domain-containing protein.	0.686
ADGRL3	LRRK2	A0A151MPZ2	A0A151NP48	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat serine/threonine-protein kinase 2.	0.686
ADGRL3	LRRTM1	A0A151MPZ2	A0A151MYL5	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat transmembrane neuronal protein 1.	0.690
ADGRL3	LRRTM4	A0A151MPZ2	A0A151P406	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Leucine-rich repeat transmembrane neuronal protein 4.	0.690
ADGRL3	LRRTM4-2	A0A151MPZ2	A0A151P5Z5	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.695