STRINGSTRING
ARMC5-1 ARMC5-1 FGF1-1 FGF1-1 FGF19 FGF19 DKK3 DKK3 IGF2-1 IGF2-1 Y1Q_0002897 Y1Q_0002897 LPCAT3 LPCAT3 SNAI2 SNAI2 CYP7A1 CYP7A1 LEP LEP REST REST DDX20 DDX20 Y1Q_0014200 Y1Q_0014200 WNT4 WNT4 FGFR4 FGFR4 H6PD H6PD SEC14L2 SEC14L2 SEC14L5 SEC14L5 SCAP SCAP ERLIN2 ERLIN2 STAR STAR BMP7 BMP7 DGKQ DGKQ SF1 SF1 ABCG1 ABCG1 SREBF2 SREBF2 DKKL1 DKKL1 ARMC5-2 ARMC5-2 Y1Q_0011870 Y1Q_0011870 ABCG1-2 ABCG1-2 TNF TNF NR0B1 NR0B1 SNAI1 SNAI1 SIRT1 SIRT1 SREBF1 SREBF1 ASAH1 ASAH1 NR1D1 NR1D1 IFNG IFNG ERLIN1 ERLIN1 STARD4 STARD4 APOB APOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARMC5-1Armadillo repeat-containing protein 5. (628 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
DKK3Dickkopf-related protein 3. (312 aa)
IGF2-1Insulin-like growth factor II isoform B. (217 aa)
Y1Q_0002897Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (474 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (278 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (168 aa)
RESTRE1-silencing transcription factor. (913 aa)
DDX20Putative ATP-dependent RNA helicase DDX20; Belongs to the DEAD box helicase family. (475 aa)
Y1Q_0014200Nuclear receptor subfamily 0 group B member 2-like. (369 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FGFR4Uncharacterized protein. (518 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein. (715 aa)
SEC14L2SEC14-like protein 2. (409 aa)
SEC14L5Uncharacterized protein. (755 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein. (1313 aa)
ERLIN2Erlin-2. (364 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (287 aa)
BMP7Bone morphogenetic protein 7. (416 aa)
DGKQDiacylglycerol kinase. (973 aa)
SF1Splicing factor 1 isoform B. (668 aa)
ABCG1ATP-binding cassette sub-family G member 1. (861 aa)
SREBF2Sterol regulatory element-binding protein 2 isoform A. (1079 aa)
DKKL1Dickkopf-like protein 1. (368 aa)
ARMC5-2Armadillo repeat-containing protein 5. (207 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
ABCG1-2ABC transporter domain-containing protein. (666 aa)
TNFTumor necrosis factor. (231 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (130 aa)
SNAI1Zinc finger protein SNAI1. (420 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
SREBF1BHLH domain-containing protein. (1085 aa)
ASAH1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (555 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
ERLIN1Erlin-1. (335 aa)
STARD4StAR-related lipid transfer protein 4. (233 aa)
APOBApolipoprotein B-100. (4482 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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