(97 nodes) Leukocyte migration network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGA3	Integrin alpha-3 isoform A; Belongs to the integrin alpha chain family. (1047 aa)
	LGALS3	Galectin. (167 aa)
	CCR6	Uncharacterized protein. (97 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (331 aa)
	SYK-2	Tyrosine-protein kinase. (608 aa)
	ROR1L	Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (934 aa)
	ANXA1	Annexin. (362 aa)
	DOCK8	Dedicator of cytokinesis protein 8 isoform B; Belongs to the DOCK family. (2131 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1474 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (233 aa)
	MDK	Midkine. (156 aa)
	Y1Q_0002953	Uncharacterized protein. (68 aa)
	XCL1	Lymphotactin. (192 aa)
	JAM2	Junctional adhesion molecule B. (298 aa)
	CXADR	Coxsackievirus and adenovirus receptor. (355 aa)
	UMODL1-1	Uromodulin-like 1 isoform B. (1195 aa)
	DBH	Dopamine beta-hydroxylase. (598 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (271 aa)
	AIMP1	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1. (366 aa)
	Y1Q_0023273	Uncharacterized protein. (599 aa)
	CD34	Hematopoietic progenitor cell antigen CD34. (386 aa)
	PODXL2	Podocalyxin-like protein 2. (630 aa)
	FAM19A4	Protein FAM19A4. (162 aa)
	CRK	Adapter molecule crk. (291 aa)
	Y1Q_0005880	Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	Y1Q_0005879	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	MMP9	Uncharacterized protein. (684 aa)
	CYP7B1	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
	F11R	Junctional adhesion molecule A. (310 aa)
	CCL17	C-C motif chemokine. (137 aa)
	CX3CL1	Fractalkine. (118 aa)
	FLT1-2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
	SLC37A4	Glucose-6-phosphate translocase. (429 aa)
	GOLPH3	Golgi phosphoprotein 3. (224 aa)
	ITGA1	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1137 aa)
	NEDD9	Enhancer of filamentation 1. (802 aa)
	UMOD	Uromodulin. (677 aa)
	PECAM1-1	Platelet endothelial cell adhesion molecule isoform A. (728 aa)
	MILR1	Allergin-1 isoform A. (337 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (620 aa)
	CXCL11	C-X-C motif chemokine. (83 aa)
	RABGEF1	Rab5 GDP/GTP exchange factor isoform C. (554 aa)
	SPNS2	Spinster-like protein 2 isoform B. (487 aa)
	NF1	Neurofibromin isoform B. (2879 aa)
	CKLF	Chemokine-like factor. (139 aa)
	CD99L2	CD99 antigen-like protein 2 isoform B. (305 aa)
	CCL21	SCY domain-containing protein. (93 aa)
	PIKFYVE	1-phosphatidylinositol 3-phosphate 5-kinase isoform A. (2159 aa)
	CCL20	C-C motif chemokine. (86 aa)
	SCG2	Secretogranin-2. (681 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
	TRPM5	Transient receptor potential cation channel subfamily M member 5. (1476 aa)
	PDGFB	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
	PTN	Pleiotrophin. (165 aa)
	IL17RA	Interleukin-17 receptor A. (832 aa)
	PTPRO	Receptor-type tyrosine-protein phosphatase O isoform B. (1189 aa)
	MCOLN2	PKD_channel domain-containing protein. (465 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (548 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14; Belongs to the tumor necrosis factor family. (236 aa)
	ITGA7	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (808 aa)
	MSN	Moesin. (602 aa)
	Y1Q_0015586	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
	IL17RE	Interleukin-17 receptor E. (1282 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
	JAM3	Junctional adhesion molecule C. (319 aa)
	TNF	Tumor necrosis factor. (231 aa)
	Y1Q_0006729	P-selectin. (763 aa)
	CCL4	C-C motif chemokine. (91 aa)
	FFAR2	Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	Y1Q_0013293	C-C motif chemokine. (102 aa)
	Y1Q_0013292	C-C motif chemokine 5-like. (91 aa)
	CD99	CD99 antigen isoform A. (194 aa)
	GAS6	Growth arrest-specific protein 6. (676 aa)
	MADCAM1	Mucosal addressin cell adhesion molecule 1. (506 aa)
	CXCL8-3	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	CXCR5	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	ITGA9	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1002 aa)
	Y1Q_0013332	Integrin_alpha2 domain-containing protein. (279 aa)
	CXCR1	C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (615 aa)
	ADD2	Beta-adducin. (745 aa)
	Y1Q_0004713	C-C motif chemokine 19-like. (72 aa)
	TBX21	T-box transcription factor TBX21. (582 aa)
	ITGA3-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1085 aa)
	NKX2-6	Homeobox protein Nkx-2.6. (289 aa)
	ANO6	Anoctamin. (930 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (468 aa)
	AMICA1	Junctional adhesion molecule-like. (277 aa)
	CSF3R	Granulocyte colony-stimulating factor receptor. (916 aa)
	EDN2	Endothelin-2. (181 aa)
	GBF1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform C. (1865 aa)
	Y1Q_0007371	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5 isoform B. (1796 aa)
	ASB2	Ankyrin repeat and SOCS box protein 2. (687 aa)
	KIT-2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (947 aa)
	CCR7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (376 aa)
	ITGA4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1036 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIMP1	SRP54	A0A151MIY1	A0A151NKE1	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1.	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.467
AMICA1	CXADR	A0A151PFX6	A0A151ME65	Junctional adhesion molecule-like.	Coxsackievirus and adenovirus receptor.	0.964
ANXA1	LGALS3	A0A151M8F4	A0A151M1X2	Annexin.	Galectin.	0.454
ARHGEF5	ROCK1	A0A151P7J2	A0A151NEK7	Rho guanine nucleotide exchange factor 5 isoform B.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.520
CCL17	CCL20	A0A151MR85	A0A151NAR5	C-C motif chemokine.	C-C motif chemokine.	0.602
CCL17	CCL4	A0A151MR85	A0A151NT95	C-C motif chemokine.	C-C motif chemokine.	0.625
CCL17	CCR7	A0A151MR85	A0A151PCI6	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.584
CCL17	CX3CL1	A0A151MR85	A0A151MRK4	C-C motif chemokine.	Fractalkine.	0.516
CCL17	CXCL11	A0A151MR85	A0A151N550	C-C motif chemokine.	C-X-C motif chemokine.	0.523
CCL17	CXCL8-3	A0A151MR85	A0A151P1Y5	C-C motif chemokine.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.596
CCL17	Y1Q_0004713	A0A151MR85	A0A151P5C2	C-C motif chemokine.	C-C motif chemokine 19-like.	0.436
CCL17	Y1Q_0013292	A0A151MR85	A0A151NU53	C-C motif chemokine.	C-C motif chemokine 5-like.	0.941
CCL17	Y1Q_0013293	A0A151MR85	A0A151NTX1	C-C motif chemokine.	C-C motif chemokine.	0.424
CCL20	CCL17	A0A151NAR5	A0A151MR85	C-C motif chemokine.	C-C motif chemokine.	0.602
CCL20	CCL21	A0A151NAR5	A0A151N8H2	C-C motif chemokine.	SCY domain-containing protein.	0.649
CCL20	CCL4	A0A151NAR5	A0A151NT95	C-C motif chemokine.	C-C motif chemokine.	0.606
CCL20	CCR6	A0A151NAR5	A0A151M2G3	C-C motif chemokine.	Uncharacterized protein.	0.993
CCL20	CCR7	A0A151NAR5	A0A151PCI6	C-C motif chemokine.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.741
CCL20	CX3CL1	A0A151NAR5	A0A151MRK4	C-C motif chemokine.	Fractalkine.	0.610
CCL20	CXCL11	A0A151NAR5	A0A151N550	C-C motif chemokine.	C-X-C motif chemokine.	0.448