STRINGSTRING
ERRFI1 ERRFI1 GPRC5A GPRC5A DUSP19 DUSP19 DTX3L DTX3L PARK2 PARK2 PARK2L PARK2L FGFR1OP-1 FGFR1OP-1 AGT AGT TNFAIP3 TNFAIP3 CDKN2C CDKN2C PIK3CB-2 PIK3CB-2 ADIPOQ ADIPOQ SPRY4 SPRY4 H2AFY H2AFY FAM72A FAM72A Y1Q_0000620 Y1Q_0000620 TSG101 TSG101 PTPRJ PTPRJ CDKN1C CDKN1C PTPN6 PTPN6 GSK3B-2 GSK3B-2 CBLB-2 CBLB-2 NPRL2 NPRL2 PARP3 PARP3 PHPT1 PHPT1 Y1Q_0002384 Y1Q_0002384 Y1Q_0015842 Y1Q_0015842 SMYD3 SMYD3 ITM2B ITM2B Y1Q_0004375 Y1Q_0004375 CAV3 CAV3 PRKAR2A PRKAR2A PIF1 PIF1 INPP5K INPP5K SH3BP5L SH3BP5L CDK5RAP1 CDK5RAP1 PKIA-1 PKIA-1 LYN LYN DTNBP1 DTNBP1 PAQR3 PAQR3 ADAR ADAR SH3BP5 SH3BP5 MIDNL MIDNL IBTK IBTK GNB2L1 GNB2L1 SPRED1 SPRED1 CHP1 CHP1 BUB1B BUB1B CHORDC1 CHORDC1 PINX1 PINX1 TP53 TP53 MIDN MIDN SMAD7 SMAD7 DEPTOR-1 DEPTOR-1 CAMK2N2 CAMK2N2 RUBCN RUBCN ZGPAT ZGPAT GSK3B GSK3B CEP85 CEP85 TMEM130 TMEM130 SMCR8 SMCR8 PRKAR1B PRKAR1B TSC2 TSC2 PRKAR1A PRKAR1A COX11 COX11 SOCS4 SOCS4 MAD2L2 MAD2L2 PIK3IP1 PIK3IP1 NF2 NF2 HSPB1 HSPB1 Y1Q_0007089 Y1Q_0007089 TFAP4 TFAP4 NF1 NF1 PPM1E PPM1E ITGB1BP1 ITGB1BP1 CDKN1A CDKN1A PTPRB PTPRB MEN1 MEN1 GBA GBA MSTN MSTN PTPRC PTPRC PYCARDL PYCARDL GDF11 GDF11 PTPN2 PTPN2 QARS QARS Y1Q_0010174 Y1Q_0010174 Y1Q_0020688 Y1Q_0020688 CBLB CBLB USP44-2 USP44-2 FBXO7 FBXO7 PTPRO PTPRO AKT1S1 AKT1S1 THY1 THY1 FBXO5 FBXO5 LATS1 LATS1 PRKAR2B PRKAR2B SORL1 SORL1 UBASH3B UBASH3B PPM1F PPM1F SH2B3 SH2B3 DDR2-2 DDR2-2 CDKN2D CDKN2D DBNDD1 DBNDD1 PRDX3-1 PRDX3-1 TRIB3 TRIB3 PLK1 PLK1 LRP5 LRP5 Y1Q_0004900 Y1Q_0004900 Y1Q_0004897 Y1Q_0004897 Y1Q_0002620 Y1Q_0002620 Y1Q_0004899 Y1Q_0004899 PTPN1 PTPN1 DBNDD2 DBNDD2 Y1Q_0020515 Y1Q_0020515 SIRT1 SIRT1 AIDA AIDA BUB3 BUB3 DUSP10 DUSP10 CHMP6 CHMP6 PIP4K2B PIP4K2B CDK5RAP3 CDK5RAP3 SRCIN1 SRCIN1 SMPD1 SMPD1 CDKN1B CDKN1B CDKN1D CDKN1D Y1Q_0022963 Y1Q_0022963 LRP6-2 LRP6-2 MYOCD MYOCD SPRY3 SPRY3 BAG5 BAG5 WARS WARS ZFYVE28 ZFYVE28 Y1Q_0021608 Y1Q_0021608 Y1Q_0021609 Y1Q_0021609 SFRP2 SFRP2 EPHA1 EPHA1 VPS25 VPS25 HEXIM1 HEXIM1 PIP4K2A PIP4K2A NCAPG2 NCAPG2 Y1Q_0019947 Y1Q_0019947 BAG2 BAG2 BMP4 BMP4 MAD2L1 MAD2L1 POT1 POT1 CAV1 CAV1 PTPRR PTPRR IFNG IFNG MXD3 MXD3 PIP4K2C PIP4K2C HMGCR HMGCR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERRFI1ERBB receptor feedback inhibitor 1. (453 aa)
GPRC5ARetinoic acid-induced protein 3. (391 aa)
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (178 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (669 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform A. (280 aa)
PARK2LRBR-type E3 ubiquitin transferase. (180 aa)
FGFR1OP-1FGFR1 oncogene partner isoform A. (397 aa)
AGTAngiotensinogen; Belongs to the serpin family. (474 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (853 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (170 aa)
PIK3CB-2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1071 aa)
ADIPOQAdiponectin. (263 aa)
SPRY4Sprouty-like protein 4. (299 aa)
H2AFYCore histone macro-H2A.1 isoform C; Belongs to the histone H2A family. (435 aa)
FAM72AProtein FAM72A. (146 aa)
Y1Q_0000620Protein kinase domain-containing protein. (901 aa)
TSG101Tumor susceptibility 101 protein. (392 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta isoform A. (1187 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (223 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
GSK3B-2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
CBLB-2Uncharacterized protein. (995 aa)
NPRL2Nitrogen permease regulator 2-like protein. (405 aa)
PARP3Poly [ADP-ribose] polymerase. (549 aa)
PHPT1Phosphohistidine phosphatase. (117 aa)
Y1Q_0002384TGFb_propeptide domain-containing protein. (154 aa)
Y1Q_0015842Histone-lysine N-methyltransferase SMYD3-like. (164 aa)
SMYD3Histone-lysine N-methyltransferase SMYD3. (254 aa)
ITM2BIntegral membrane protein 2B isoform B. (1151 aa)
Y1Q_0004375Phosphohistidine phosphatase-like. (119 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (355 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (479 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform B. (472 aa)
SH3BP5LSH3 domain-binding protein 5-like. (366 aa)
CDK5RAP1CDK5 regulatory subunit-associated protein 1. (555 aa)
PKIA-1cAMP-dependent protein kinase inhibitor alpha isoform A. (138 aa)
LYNTyrosine-protein kinase. (562 aa)
DTNBP1Dysbindin. (352 aa)
PAQR3Progestin and adipoQ receptor family member 3. (244 aa)
ADARDouble-stranded RNA-specific adenosine deaminase. (1059 aa)
SH3BP5SH3 domain-binding protein 5 isoform B. (432 aa)
MIDNLMidnolin. (361 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1353 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
CHP1Calcineurin B-like proteinous protein 1. (195 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (997 aa)
CHORDC1Cysteine and histidine-rich domain-containing protein 1. (329 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (232 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
MIDNMidnolin. (80 aa)
SMAD7Mothers against decapentaplegic homolog. (384 aa)
DEPTOR-1DEP domain-containing mTOR-interacting protein isoform B. (397 aa)
CAMK2N2Calcium/calmodulin-dependent protein kinase II inhibitor 2. (78 aa)
RUBCNRun domain Beclin-1 interacting and cysteine-rich containing protein isoform A. (1001 aa)
ZGPATZinc finger CCCH-type with G patch domain-containing protein. (543 aa)
GSK3BGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (413 aa)
CEP85Centrosomal protein of. (785 aa)
TMEM130Transmembrane protein 130. (487 aa)
SMCR8Smith-Magenis syndrome chromosomal region candidate 8 protein. (935 aa)
PRKAR1BUncharacterized protein. (413 aa)
TSC2Tuberin isoform D. (1829 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
COX11Cytochrome c oxidase assembly protein COX11, mitochondrial. (171 aa)
SOCS4Suppressor of cytokine signaling 4. (321 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (228 aa)
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1. (262 aa)
NF2Merlin isoform A. (593 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (217 aa)
Y1Q_0007089FERM domain-containing protein. (665 aa)
TFAP4Transcription factor AP-4. (344 aa)
NF1Neurofibromin isoform B. (2879 aa)
PPM1EProtein phosphatase 1E isoform B. (677 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (232 aa)
PTPRBReceptor-type tyrosine-protein phosphatase beta. (2275 aa)
MEN1Menin. (456 aa)
GBAGlucosylceramidase. (779 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
GDF11Growth/differentiation factor 11. (375 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (429 aa)
QARSGlutamine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (782 aa)
Y1Q_0010174UBA domain-containing protein. (189 aa)
Y1Q_0020688Glucosylceramidase. (347 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (526 aa)
USP44-2USP domain-containing protein; Belongs to the peptidase C19 family. (309 aa)
FBXO7F-box only protein 7. (531 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform B. (1189 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
THY1Thy-1 membrane glycoprotein. (195 aa)
FBXO5F-box only protein 5. (431 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform A. (867 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit isoform B. (408 aa)
SORL1Sortilin-related receptor isoform B. (2170 aa)
UBASH3BUbiquitin-associated and SH3 domain-containing protein B. (638 aa)
PPM1FProtein phosphatase 1F isoform B. (502 aa)
SH2B3SH2B adapter protein 3. (600 aa)
DDR2-2Uncharacterized protein. (857 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (167 aa)
DBNDD1Dysbindin domain-containing protein 1. (156 aa)
PRDX3-1Thioredoxin-dependent peroxide reductase, mitochondrial isoform A. (385 aa)
TRIB3Tribbles-like protein 3. (340 aa)
PLK1Serine/threonine-protein kinase PLK. (664 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1594 aa)
Y1Q_0004900Uncharacterized protein. (226 aa)
Y1Q_0004897Uncharacterized protein. (202 aa)
Y1Q_0002620Uncharacterized protein. (466 aa)
Y1Q_0004899Death domain-containing protein. (80 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
DBNDD2Dysbindin domain-containing protein 2. (125 aa)
Y1Q_0020515Pyrin domain-containing protein. (72 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
AIDAAxin interactor, dorsalization-associated protein. (306 aa)
BUB3Mitotic checkpoint protein BUB3. (384 aa)
DUSP10Dual specificity protein phosphatase 10. (479 aa)
CHMP6Charged multivesicular body protein 6. (187 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (411 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3. (534 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1697 aa)
SMPD1Sphingomyelin phosphodiesterase. (287 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (131 aa)
CDKN1DCyclin-dependent kinase inhibitor 1D. (153 aa)
Y1Q_0022963Non-specific serine/threonine protein kinase. (692 aa)
LRP6-2Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
MYOCDMyocardin isoform A. (934 aa)
SPRY3Sprouty-like protein 3 isoform A. (305 aa)
BAG5BAG family molecular chaperone regulator 5. (450 aa)
WARSTryptophan--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (473 aa)
ZFYVE28Lateral signaling target 2-like protein. (961 aa)
Y1Q_0021608Cyclic nucleotide-binding domain-containing protein. (327 aa)
Y1Q_0021609Uncharacterized protein. (110 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
EPHA1Uncharacterized protein. (983 aa)
VPS25Vacuolar protein-sorting-associated protein 25. (174 aa)
HEXIM1Protein HEXIM1. (139 aa)
PIP4K2APIPK domain-containing protein. (405 aa)
NCAPG2Condensin-2 complex subunit G2. (1146 aa)
Y1Q_0019947Uncharacterized protein. (264 aa)
BAG2BAG family molecular chaperone regulator 2. (208 aa)
BMP4Bone morphogenetic protein 4. (348 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
POT1Protection of telomeres protein 1. (821 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PTPRRReceptor-type tyrosine-protein phosphatase R. (2872 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (125 aa)
MXD3Lateral signaling target 2-like protein. (583 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (458 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (914 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (28%) [HD]