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POLD1-2 POLD1-2 DPYD DPYD IREB2 IREB2 SDHB SDHB CDK5RAP1 CDK5RAP1 Y1Q_0018529 Y1Q_0018529 CIAPIN1 CIAPIN1 Y1Q_0019557 Y1Q_0019557 ERCC2 ERCC2 TNFRSF6B TNFRSF6B NUBP1 NUBP1 NTHL1 NTHL1 RSAD1 RSAD1 NDUFV1 NDUFV1 TYW1 TYW1 EXO5 EXO5 BRIP1 BRIP1 NUBP2 NUBP2 RSAD2 RSAD2 NDUFS1 NDUFS1 INO80D INO80D SERP1 SERP1 DPH2 DPH2 ACO1 ACO1 E2F3 E2F3 ACO2 ACO2 Y1Q_0000842 Y1Q_0000842 Y1Q_0000841 Y1Q_0000841 POLE POLE ISCA2 ISCA2 NUBPL NUBPL DNA2 DNA2 Y1Q_0006787 Y1Q_0006787 ELP3 ELP3 Y1Q_0007595 Y1Q_0007595 MOCS1 MOCS1 NFU1 NFU1 LIAS LIAS PPAT PPAT ETFDH ETFDH DPH1 DPH1 PRIM2 PRIM2 NDUFS2 NDUFS2 NDUFS7 NDUFS7 MUTYH MUTYH POLD1 POLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD1-2DNA polymerase delta catalytic subunit. (392 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
IREB2Uncharacterized protein; Belongs to the aconitase/IPM isomerase family. (965 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (277 aa)
CDK5RAP1CDK5 regulatory subunit-associated protein 1. (555 aa)
Y1Q_0018529Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (275 aa)
Y1Q_0019557Uncharacterized protein. (106 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
TNFRSF6BRegulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1658 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1. (266 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (377 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (481 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial. (792 aa)
TYW1S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase. (721 aa)
EXO5Exonuclease V. (342 aa)
BRIP1Fanconi anemia group J protein isoform A. (1463 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (272 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (338 aa)
NDUFS1NADH-ubiquinone oxidoreductase subunit, mitochondrial; Belongs to the complex I 75 kDa subunit family. (766 aa)
INO80DINO80 complex subunit D. (1029 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
DPH22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (416 aa)
ACO1Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (889 aa)
E2F3Transcription factor E2F3 isoform C. (928 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
Y1Q_0000842DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (917 aa)
Y1Q_0000841DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (311 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
ISCA2Iron-sulfur cluster assembly 2-like protein, mitochondrial. (117 aa)
NUBPLIron-sulfur protein NUBPL. (311 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1052 aa)
Y1Q_0006787DNA polymerase delta catalytic subunit-like. (198 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (558 aa)
Y1Q_0007595DNA_pol_B_exo1 domain-containing protein. (86 aa)
MOCS1Molybdenum cofactor biosynthesis protein 1. (675 aa)
NFU1NFU1 iron-sulfur cluster scaffold-like protein, mitochondrial. (249 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (387 aa)
PPATAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (527 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (618 aa)
DPH1Diphthamide biosynthesis protein 1. (178 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (503 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Belongs to the complex I 49 kDa subunit family. (455 aa)
NDUFS7NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Belongs to the complex I 20 kDa subunit family. (204 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (505 aa)
POLD1DNA polymerase. (439 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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