49 items (Alligator mississippiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRY1	Cryptochrome 4. (665 aa)
	CREBBP	CREB-binding protein isoform C. (2208 aa)
	PDZD3	Na(+)/H(+) exchange regulatory cofactor NHE-RF4. (413 aa)
	Y1Q_0017061	Uncharacterized protein. (161 aa)
	ATP2B4-2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1293 aa)
	ERLIN2	Erlin-2. (364 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein. (217 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial. (305 aa)
	FAM132A	Adipolin. (569 aa)
	FLCN	Folliculin. (629 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	MST1	Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
	REST	RE1-silencing transcription factor. (913 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	MFSD2A	Sodium-dependent lysophosphatidylcholine symporter 1 isoform A. (503 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (125 aa)
	PLEK	Pleckstrin. (352 aa)
	SLC27A4	AMP-binding domain-containing protein. (650 aa)
	DKK3	Dickkopf-related protein 3. (312 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	PRMT3	Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (517 aa)
	ADIPOQ	Adiponectin. (263 aa)
	ACMSD	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (338 aa)
	FAM3A	Protein FAM3A. (232 aa)
	ERLIN1	Erlin-1. (335 aa)
	FAM3C	Protein FAM3C. (227 aa)
	STAT4	Signal transducer and activator of transcription. (849 aa)
	BRCA1	Breast cancer type 1 susceptibility protein. (832 aa)
	Y1Q_0015122	Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (246 aa)
	TSPO	Translocator protein. (244 aa)
	PPARAB	Peroxisome proliferator-activated receptor alpha. (438 aa)
	TIGAR	Fructose-2,6-bisphosphatase TIGAR. (272 aa)
	TSPO2	Translocator protein 2. (164 aa)
	RD3	Protein RD3. (174 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1000 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	SNAI1	Zinc finger protein SNAI1. (420 aa)
	DDIT4	DNA damage-inducible transcript 4 protein. (172 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (357 aa)
	ATCAY	Caytaxin. (425 aa)
	SOGA1	Protein SOGA1 isoform A. (1537 aa)
	TRIB3	Tribbles-like protein 3. (340 aa)
	PIBF1	Progesterone-induced-blocking factor 1 isoform B. (756 aa)
	DKKL1	Dickkopf-like protein 1. (368 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1. (664 aa)
	LEPR-1	Leptin receptor isoform B. (528 aa)
	METTL20	Protein N-lysine methyltransferase METTL20. (241 aa)
	APPL2	Uncharacterized protein. (659 aa)
	Y1Q_0024039	KIX domain-containing protein. (131 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL2	A0A151M626	A0A151NI35	Adiponectin.	Uncharacterized protein.	0.716
ADIPOQ	LEPR-1	A0A151M626	A0A151NJP3	Adiponectin.	Leptin receptor isoform B.	0.542
ADIPOQ	PPARAB	A0A151M626	A0A151P784	Adiponectin.	Peroxisome proliferator-activated receptor alpha.	0.595
ADIPOQ	SIRT1	A0A151M626	A0A151P0R7	Adiponectin.	NAD-dependent protein deacetylase sirtuin-1.	0.541
APPL2	ADIPOQ	A0A151NI35	A0A151M626	Uncharacterized protein.	Adiponectin.	0.716
BRCA1	CREBBP	A0A151PBW5	A0A151NHH3	Breast cancer type 1 susceptibility protein.	CREB-binding protein isoform C.	0.696
BRCA1	PARP1	A0A151PBW5	A0A151P373	Breast cancer type 1 susceptibility protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.683
BRCA1	STAT4	A0A151PBW5	A0A151PC08	Breast cancer type 1 susceptibility protein.	Signal transducer and activator of transcription.	0.466
BRCA1	TP53	A0A151PBW5	A0A151MW63	Breast cancer type 1 susceptibility protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.968
BRCA1	Y1Q_0024039	A0A151PBW5	A0A151NHX4	Breast cancer type 1 susceptibility protein.	KIX domain-containing protein.	0.696
CREBBP	BRCA1	A0A151NHH3	A0A151PBW5	CREB-binding protein isoform C.	Breast cancer type 1 susceptibility protein.	0.696
CREBBP	PARP1	A0A151NHH3	A0A151P373	CREB-binding protein isoform C.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.516
CREBBP	PPARAB	A0A151NHH3	A0A151P784	CREB-binding protein isoform C.	Peroxisome proliferator-activated receptor alpha.	0.692
CREBBP	PRMT3	A0A151NHH3	A0A151MBK9	CREB-binding protein isoform C.	Protein arginine N-methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.428
CREBBP	SIRT1	A0A151NHH3	A0A151P0R7	CREB-binding protein isoform C.	NAD-dependent protein deacetylase sirtuin-1.	0.563
CREBBP	STAT4	A0A151NHH3	A0A151PC08	CREB-binding protein isoform C.	Signal transducer and activator of transcription.	0.897
CREBBP	TP53	A0A151NHH3	A0A151MW63	CREB-binding protein isoform C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.993
CRY1	SIRT1	A0A151NHX9	A0A151P0R7	Cryptochrome 4.	NAD-dependent protein deacetylase sirtuin-1.	0.458
CRY1	TSPO	A0A151NHX9	A0A151P8B6	Cryptochrome 4.	Translocator protein.	0.460
CRY1	TSPO2	A0A151NHX9	A0A151P4P2	Cryptochrome 4.	Translocator protein 2.	0.460