STRINGSTRING
RASGRP1-2 RASGRP1-2 Y1Q_0009747 Y1Q_0009747 YWHAZ YWHAZ TRAF7 TRAF7 WNK2 WNK2 SPRED3 SPRED3 EMILIN1 EMILIN1 FLCN FLCN FGFR4 FGFR4 Y1Q_0006103 Y1Q_0006103 LIF LIF FBXW9 FBXW9 Y1Q_0013039 Y1Q_0013039 Y1Q_0013038 Y1Q_0013038 VRK3-1 VRK3-1 CCL1 CCL1 FAM150B FAM150B ITGB1BP1 ITGB1BP1 CIB1 CIB1 CCL21 CCL21 FBXW7 FBXW7 FN1 FN1 ACKR3 ACKR3 CCL20 CCL20 CUNH3orf33 CUNH3orf33 DUSP26 DUSP26 PTPRC PTPRC PKHD1 PKHD1 PYCARDL PYCARDL TEK TEK ADCYAP1 ADCYAP1 PTPN2 PTPN2 TNFRSF11A TNFRSF11A TIRAP TIRAP PDGFB PDGFB TIMP3 TIMP3 BRAF-2 BRAF-2 CYR61 CYR61 FGF21 FGF21 AKAP12 AKAP12 Y1Q_0011870 Y1Q_0011870 NPM3 NPM3 FGF18 FGF18 PTPN11 PTPN11 CCL38A.5 CCL38A.5 CCL4 CCL4 DDR2-2 DDR2-2 Y1Q_0013293 Y1Q_0013293 Y1Q_0013292 Y1Q_0013292 PIN1 PIN1 GAS6 GAS6 PTPN1 PTPN1 FAM83D FAM83D FAM83DL FAM83DL TGFB1 TGFB1 FFAR4 FFAR4 DNAJC27 DNAJC27 RAMP3 RAMP3 BMPER BMPER SLC30A10 SLC30A10 ATF3 ATF3 DUSP10 DUSP10 Y1Q_0004713 Y1Q_0004713 PHB PHB FGF23 FGF23 FBLN1 FBLN1 LRRC30 LRRC30 SPRY3 SPRY3 PSCA PSCA FGFR3 FGFR3 KDR KDR HAND2 HAND2 PDGFC PDGFC FGG FGG RAPGEF2-2 RAPGEF2-2 DUSP3 DUSP3 FBXW7-2 FBXW7-2 ITGB3-2 ITGB3-2 FGB FGB STYX STYX BMP4 BMP4 ANKRD26 ANKRD26 TNIP3 TNIP3 FRS2 FRS2 RIPK2 RIPK2 JUND JUND GLIPR2 GLIPR2 P2RY6 P2RY6 SMAD4 SMAD4 NDRG2 NDRG2 c-jun c-jun SERPINF2 SERPINF2 ERRFI1 ERRFI1 MARCO MARCO OPRM1 OPRM1 EZR EZR MAP2K7 MAP2K7 ROS1 ROS1 CTGF CTGF DUSP9 DUSP9 SEMA7AL SEMA7AL ADIPOQ ADIPOQ SPRY4 SPRY4 FGF1-1 FGF1-1 CD74 CD74 FLT1 FLT1 PDGFRA PDGFRA KIT KIT SLAMF1 SLAMF1 SYK-2 SYK-2 AAED1 AAED1 TNFAIP8L3 TNFAIP8L3 SEMA7A SEMA7A SYNJ2BP-1 SYNJ2BP-1 DSTYK DSTYK APIP APIP FGF4 FGF4 FGF19 FGF19 PTPN6 PTPN6 CD4 CD4 Y1Q_0002953 Y1Q_0002953 XCL1 XCL1 APP APP ABL1-2 ABL1-2 CARD9 CARD9 Y1Q_0002384 Y1Q_0002384 HTR2A HTR2A TNFSF11 TNFSF11 ABL1 ABL1 PLA2G5 PLA2G5 EPHA2 EPHA2 NPTN NPTN RIPK3L RIPK3L IL1BL IL1BL Y1Q_0001844 Y1Q_0001844 GAREM1 GAREM1 LYN LYN MFHAS1 MFHAS1 GPNMB GPNMB NEK10 NEK10 CCL17 CCL17 GAREM2 GAREM2 NOD1 NOD1 CX3CL1 CX3CL1 NDRG4 NDRG4 TBC1D10C TBC1D10C TNIP1 TNIP1 SPRED1 SPRED1 NOX4 NOX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASGRP1-2Uncharacterized protein. (744 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (319 aa)
TRAF7E3 ubiquitin-protein ligase TRAF7. (670 aa)
WNK2Protein kinase domain-containing protein. (2096 aa)
SPRED3Sprouty-related, EVH1 domain-containing protein 3. (700 aa)
EMILIN1EMILIN-1. (1017 aa)
FLCNFolliculin. (629 aa)
FGFR4Uncharacterized protein. (518 aa)
Y1Q_0006103Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LIFLeukemia inhibitory factor. (211 aa)
FBXW9F-box/WD repeat-containing protein 9. (457 aa)
Y1Q_0013039C-C motif chemokine. (90 aa)
Y1Q_0013038C-C motif chemokine. (90 aa)
VRK3-1Inactive serine/threonine-protein kinase VRK3 isoform A. (407 aa)
CCL1Chemokine (C-C motif) ligand 1. (96 aa)
FAM150BProtein FAM150B. (124 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
CIB1Calcium and integrin-binding protein 1. (190 aa)
CCL21SCY domain-containing protein. (93 aa)
FBXW7F-box/WD repeat-containing protein 7. (665 aa)
FN1Fibronectin isoform A. (2483 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CCL20C-C motif chemokine. (86 aa)
CUNH3orf33Uncharacterized protein. (120 aa)
DUSP26Dual specificity protein phosphatase 26; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (245 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
PKHD1Fibrocystin isoform B. (4049 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
TEKAngiopoietin-1 receptor. (1114 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (184 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (429 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (669 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (230 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
TIMP3Metalloproteinase inhibitor 3. (212 aa)
BRAF-2Uncharacterized protein. (791 aa)
CYR61Protein CYR61. (374 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
AKAP12A-kinase anchor protein 12. (1999 aa)
Y1Q_0011870Pkinase_Tyr domain-containing protein. (94 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
CCL38A.5SCY domain-containing protein. (83 aa)
CCL4C-C motif chemokine. (91 aa)
DDR2-2Uncharacterized protein. (857 aa)
Y1Q_0013293C-C motif chemokine. (102 aa)
Y1Q_0013292C-C motif chemokine 5-like. (91 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (159 aa)
GAS6Growth arrest-specific protein 6. (676 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
FAM83DProtein FAM83D. (456 aa)
FAM83DLProtein FAM83D-B. (307 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
FFAR4Free fatty acid receptor 4. (353 aa)
DNAJC27DnaJ-like protein subfamily C member 27. (273 aa)
RAMP3Receptor activity-modifying protein 3. (159 aa)
BMPERBMP-binding endothelial regulator protein isoform A. (677 aa)
SLC30A10Zinc transporter 10. (197 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (220 aa)
DUSP10Dual specificity protein phosphatase 10. (479 aa)
Y1Q_0004713C-C motif chemokine 19-like. (72 aa)
PHBProhibitin. (273 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (713 aa)
LRRC30Leucine-rich repeat-containing protein 30. (263 aa)
SPRY3Sprouty-like protein 3 isoform A. (305 aa)
PSCAProstate stem cell antigen. (125 aa)
FGFR3Fibroblast growth factor receptor. (837 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1353 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (121 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
FGGFibrinogen gamma chain. (431 aa)
RAPGEF2-2Uncharacterized protein. (1669 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
FBXW7-2Uncharacterized protein. (674 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
FGBFibrinogen beta chain. (493 aa)
STYXSerine/threonine/tyrosine-interacting protein. (223 aa)
BMP4Bone morphogenetic protein 4. (348 aa)
ANKRD26Ankyrin repeat domain-containing protein 26 isoform A. (824 aa)
TNIP3TNFAIP3-interacting protein 3 isoform B. (427 aa)
FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (561 aa)
JUNDBZIP domain-containing protein. (87 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (137 aa)
P2RY6p2Y purinoceptor 6. (329 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
NDRG2Protein NDRG2 isoform B. (394 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
SERPINF2Alpha-2-antiplasmin; Belongs to the serpin family. (428 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (453 aa)
MARCOMacrophage receptor MARCO. (532 aa)
OPRM1Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (399 aa)
EZRFERM domain-containing protein. (561 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform C. (488 aa)
ROS1Tyrosine-protein kinase receptor. (2310 aa)
CTGFConnective tissue growth factor. (341 aa)
DUSP9Dual specificity protein phosphatase 9. (429 aa)
SEMA7ALSemaphorin-7A isoform B; Belongs to the semaphorin family. (629 aa)
ADIPOQAdiponectin. (263 aa)
SPRY4Sprouty-like protein 4. (299 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CD74HLA class II histocompatibility antigen gamma chain; Belongs to the universal ribosomal protein uS11 family. (513 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1725 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1097 aa)
KITMast/stem cell growth factor receptor Kit isoform B; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (962 aa)
SLAMF1Signaling lymphocytic activation molecule. (331 aa)
SYK-2Tyrosine-protein kinase. (608 aa)
AAED1Thioredoxin-like protein AAED1 isoform A. (244 aa)
TNFAIP8L3Tumor necrosis factor alpha-induced protein 8-like protein 3. (255 aa)
SEMA7ASemaphorin-7A; Belongs to the semaphorin family. (629 aa)
SYNJ2BP-1Synaptojanin-2-binding protein. (145 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform B. (908 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (240 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (613 aa)
CD4T-cell surface glycoprotein CD4. (551 aa)
Y1Q_0002953Uncharacterized protein. (68 aa)
XCL1Lymphotactin. (192 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (743 aa)
ABL1-2Tyrosine-protein kinase. (1139 aa)
CARD9Caspase recruitment domain-containing protein 9. (532 aa)
Y1Q_0002384TGFb_propeptide domain-containing protein. (154 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (489 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (271 aa)
ABL1Tyrosine-protein kinase. (665 aa)
PLA2G5Phospholipase A(2). (137 aa)
EPHA2Uncharacterized protein. (979 aa)
NPTNNeuroplastin. (270 aa)
RIPK3LReceptor-interacting serine/threonine-protein kinase 2. (564 aa)
IL1BLInterleukin-1. (280 aa)
Y1Q_0001844Interleukin-1. (129 aa)
GAREM1GRB2-associated and regulator of MAPK protein. (574 aa)
LYNTyrosine-protein kinase. (562 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1. (868 aa)
GPNMBTransmembrane glycoprotein NMB. (575 aa)
NEK10Serine/threonine-protein kinase Nek10 isoform A. (1162 aa)
CCL17C-C motif chemokine. (137 aa)
GAREM2GRB2-associated and regulator of MAPK protein-like isoform B. (798 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (951 aa)
CX3CL1Fractalkine. (118 aa)
NDRG4Protein NDRG4 isoform C. (403 aa)
TBC1D10CCarabin. (526 aa)
TNIP1TNFAIP3-interacting protein 1. (586 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (314 aa)
NOX4NADPH oxidase 4 isoform B. (628 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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