STRINGSTRING
ECM1 ECM1 FGF4 FGF4 FGF19 FGF19 PTPRJ PTPRJ IL11 IL11 VEGFA-1 VEGFA-1 NPTN NPTN PGF-1 PGF-1 IL1RAP-1 IL1RAP-1 Y1Q_0001846 Y1Q_0001846 IL1BL IL1BL Y1Q_0001844 Y1Q_0001844 IL7 IL7 LYN LYN FGF5 FGF5 IL6 IL6 GREM1 GREM1 GDNF GDNF FGF10 FGF10 ESM1 ESM1 TNK2 TNK2 FGF21 FGF21 PDGFB PDGFB PYCARDL PYCARDL FRS3 FRS3 FGF17-1 FGF17-1 TLR5 TLR5 IL12A IL12A RQCD1 RQCD1 ADAM17 ADAM17 CDH5 CDH5 EPGN EPGN EREG EREG BTC BTC GRB2 GRB2 TIMM50 TIMM50 GRAP GRAP FIGF FIGF SNX4 SNX4 FGF16 FGF16 NPM3 NPM3 GATA3 GATA3 FGF18 FGF18 ATXN2 ATXN2 IL1RN IL1RN CNTF CNTF NRTN NRTN PDCL3 PDCL3 Y1Q_0006438 Y1Q_0006438 MS4A1 MS4A1 MS4A8 MS4A8 RNF126 RNF126 FGF22 FGF22 RNF41 RNF41 TGFA TGFA CSF3 CSF3 FGF23 FGF23 FGF6 FGF6 FGF9 FGF9 PDGFD PDGFD FLRT3 FLRT3 FGF20 FGF20 PDGFC PDGFC VEGFC VEGFC PDCL2 PDCL2 ITGB3-2 ITGB3-2 MYD88 MYD88 FGF2 FGF2 FRS2 FRS2 IRAK4 IRAK4 PIBF1 PIBF1 CADM4 CADM4 GLMN GLMN FGF1-1 FGF1-1 PDGFRA PDGFRA NCSTN NCSTN SNX1 SNX1 FGF7-2 FGF7-2 LINGO1 LINGO1 SNX1-2 SNX1-2 FGF3 FGF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ECM1Extracellular matrix protein 1. (420 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta isoform A. (1187 aa)
IL11Interleukin-11. (182 aa)
VEGFA-1Vascular endothelial growth factor A isoform A; Belongs to the PDGF/VEGF growth factor family. (216 aa)
NPTNNeuroplastin. (270 aa)
PGF-1Placenta growth factor isoform A; Belongs to the PDGF/VEGF growth factor family. (219 aa)
IL1RAP-1Interleukin-1 receptor accessory protein isoform B. (852 aa)
Y1Q_0001846Uncharacterized protein. (71 aa)
IL1BLInterleukin-1. (280 aa)
Y1Q_0001844Interleukin-1. (129 aa)
IL7Interleukin 7. (175 aa)
LYNTyrosine-protein kinase. (562 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
IL6Interleukin-6. (178 aa)
GREM1Gremlin-1. (216 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
ESM1Endothelial cell-specific molecule 1. (185 aa)
TNK2Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
PYCARDLApoptosis-associated speck-like protein containing a CARD. (192 aa)
FRS3Fibroblast growth factor receptor substrate 3. (556 aa)
FGF17-1Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
TLR5Toll-like receptor 5. (443 aa)
IL12AInterleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (144 aa)
RQCD1Cell differentiation RCD1-like protein isoform A. (309 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (733 aa)
EPGNEpigen isoform B. (150 aa)
EREGProepiregulin. (159 aa)
BTCProbetacellulin. (170 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (338 aa)
GRAPGRB2-related adapter protein. (217 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
SNX4Sorting nexin-4 isoform A. (423 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (179 aa)
ATXN2Uncharacterized protein. (1620 aa)
IL1RNInterleukin-1. (177 aa)
CNTFCiliary neurotrophic factor. (194 aa)
NRTNNeurturin. (196 aa)
PDCL3Phosducin-like protein 3. (241 aa)
Y1Q_0006438Membrane-spanning 4-domains subfamily A member 12-like. (203 aa)
MS4A1B-lymphocyte antigen CD20. (189 aa)
MS4A8Membrane-spanning 4-domains subfamily A member 8. (292 aa)
RNF126E3 ubiquitin-protein ligase RNF126. (313 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (141 aa)
RNF41E3 ubiquitin-protein ligase NRDP1. (261 aa)
TGFAProtransforming growth factor alpha. (159 aa)
CSF3Granulocyte colony-stimulating factor. (154 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFDPlatelet-derived growth factor D. (370 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (661 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (347 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
PDCL2Phosducin-like protein 2. (249 aa)
ITGB3-2Integrin beta; Belongs to the integrin beta chain family. (783 aa)
MYD88Myeloid differentiation primary response protein MyD88. (203 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FRS2Fibroblast growth factor receptor substrate 2. (510 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (468 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform B. (756 aa)
CADM4Cell adhesion molecule 4. (428 aa)
GLMNGlomulin isoform A. (643 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1097 aa)
NCSTNNicastrin. (718 aa)
SNX1Sorting nexin-1. (516 aa)
FGF7-2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
LINGO1Ig-like domain-containing protein. (606 aa)
SNX1-2PX domain-containing protein. (518 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.