STRINGSTRING
NOTCH2 NOTCH2 DLL1 DLL1 NUP133 NUP133 TCF21 TCF21 AHI1 AHI1 HS2ST1 HS2ST1 LAMB2 LAMB2 FGF1-1 FGF1-1 PTCH1 PTCH1 Y1Q_0000589 Y1Q_0000589 WT1 WT1 JAG1-2 JAG1-2 Y1Q_0002384 Y1Q_0002384 KIF26B KIF26B NPHS2 NPHS2 ENPEP ENPEP CD24 CD24 NUP160 NUP160 SULF1-2 SULF1-2 NOTCH3 NOTCH3 IRX3 IRX3 GREM1 GREM1 Y1Q_0009747 Y1Q_0009747 GDNF GDNF ILK ILK WNT1 WNT1 SOX8 SOX8 DLL3 DLL3 PECAM1-1 PECAM1-1 MILR1 MILR1 PKD1 PKD1 Y1Q_0016466 Y1Q_0016466 NUP85 NUP85 AQP11 AQP11 HNF1B HNF1B GREB1 GREB1 WNT9B WNT9B MPV17 MPV17 NPHS1L NPHS1L IRX1 IRX1 ZNF568-2 ZNF568-2 WNT6 WNT6 ZNF568 ZNF568 GREB1L GREB1L Y1Q_0008043 Y1Q_0008043 PDGFB PDGFB PTPRO PTPRO EDNRB EDNRB NPHS1 NPHS1 FOXC2-1 FOXC2-1 DSPP DSPP PKD2 PKD2 COMMD5 COMMD5 NPM3 NPM3 Y1Q_0023392 Y1Q_0023392 GATA3 GATA3 MAGI2 MAGI2 PODXL-1 PODXL-1 SMO SMO PAX8 PAX8 DCHS1 DCHS1 FOXQ2 FOXQ2 BASP1 BASP1 PLCE1 PLCE1 SULF1 SULF1 TMEM59L TMEM59L GLI3 GLI3 CTNNB1 CTNNB1 Y1Q_0017744 Y1Q_0017744 ITGA3-2 ITGA3-2 Y1Q_0007371 Y1Q_0007371 MTSS1 MTSS1 Y1Q_0021823 Y1Q_0021823 DCHS2-2 DCHS2-2 EDNRA EDNRA AQP1 AQP1 BMP4 BMP4 FGF2 FGF2 SMAD4 SMAD4 NUP107 NUP107 Y1Q_0017122 Y1Q_0017122 CALB1 CALB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH2Neurogenic locus notch-like protein 2. (1373 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (735 aa)
NUP133Nuclear pore complex protein Nup133. (1154 aa)
TCF21Transcription factor 21. (179 aa)
AHI1Jouberin isoform A. (1231 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (352 aa)
LAMB2Uncharacterized protein. (1523 aa)
FGF1-1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PTCH1Patched-like protein 1. (1479 aa)
Y1Q_0000589LRRNT domain-containing protein. (686 aa)
WT1Wilms tumor protein-like protein isoform A. (409 aa)
JAG1-2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1147 aa)
Y1Q_0002384TGFb_propeptide domain-containing protein. (154 aa)
KIF26BKinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1988 aa)
NPHS2Podocin. (385 aa)
ENPEPAminopeptidase. (970 aa)
CD24CD24 molecule. (84 aa)
NUP160Nuclear pore complex protein Nup160. (1373 aa)
SULF1-2Extracellular sulfatase. (898 aa)
NOTCH3Neurogenic locus notch-like protein 3-like. (409 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (246 aa)
GREM1Gremlin-1. (216 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
ILKIntegrin-linked protein kinase. (452 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
SOX8Transcription factor SOX-8. (471 aa)
DLL3Delta-like protein 3. (230 aa)
PECAM1-1Platelet endothelial cell adhesion molecule isoform A. (728 aa)
MILR1Allergin-1 isoform A. (337 aa)
PKD1Polycystin-1. (4307 aa)
Y1Q_0016466Uncharacterized protein. (4317 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (620 aa)
AQP11Aquaporin-11. (128 aa)
HNF1BHomeobox domain-containing protein. (562 aa)
GREB1Protein GREB1. (1950 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
MPV17Protein Mpv17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (82 aa)
NPHS1LNephrin. (513 aa)
IRX1Iroquois-class homeodomain protein IRX-1. (307 aa)
ZNF568-2GDNF-inducible zinc finger protein 1-like. (794 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
ZNF568GDNF-inducible zinc finger protein 1. (702 aa)
GREB1LUncharacterized protein. (1993 aa)
Y1Q_0008043Fork-head domain-containing protein. (90 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (234 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform B. (1189 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (383 aa)
NPHS1Nephrin isoform B. (597 aa)
FOXC2-1Forkhead box protein C2 isoform B. (462 aa)
DSPPDentin sialophosphoprotein isoform A. (931 aa)
PKD2EF-hand domain-containing protein. (818 aa)
COMMD5COMM domain-containing protein 5. (189 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
Y1Q_0023392PDZ domain-containing protein. (102 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
MAGI2Uncharacterized protein. (1393 aa)
PODXL-1Podocalyxin isoform A. (328 aa)
SMOSmoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (804 aa)
PAX8Paired box protein Pax-8. (373 aa)
DCHS1Uncharacterized protein. (1707 aa)
FOXQ2Forkhead box Q2. (207 aa)
BASP1Brain acid soluble protein 1. (244 aa)
PLCE1Phosphoinositide phospholipase C. (1921 aa)
SULF1Extracellular sulfatase. (950 aa)
TMEM59LTransmembrane protein 59-like. (297 aa)
GLI3Uncharacterized protein. (1572 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
Y1Q_0017744Uncharacterized protein. (85 aa)
ITGA3-2Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1085 aa)
Y1Q_0007371G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
MTSS1Metastasis suppressor protein 1 isoform B. (788 aa)
Y1Q_0021823CA domain-containing protein. (135 aa)
DCHS2-2Uncharacterized protein. (2835 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
BMP4Bone morphogenetic protein 4. (348 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (859 aa)
Y1Q_0017122Uncharacterized protein. (469 aa)
CALB1Calbindin. (262 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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