(64 nodes) Nephron epithelium development network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (735 aa)
	TCF21	Transcription factor 21. (179 aa)
	AHI1	Jouberin isoform A. (1231 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (352 aa)
	LAMB2	Uncharacterized protein. (1523 aa)
	FGF1-1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	PTCH1	Patched-like protein 1. (1479 aa)
	Y1Q_0000589	LRRNT domain-containing protein. (686 aa)
	WT1	Wilms tumor protein-like protein isoform A. (409 aa)
	JAG1-2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1147 aa)
	Y1Q_0002384	TGFb_propeptide domain-containing protein. (154 aa)
	KIF26B	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1988 aa)
	NPHS2	Podocin. (385 aa)
	CD24	CD24 molecule. (84 aa)
	IRX3	Iroquois-class homeodomain protein IRX-3. (246 aa)
	GREM1	Gremlin-1. (216 aa)
	Y1Q_0009747	Mothers against decapentaplegic homolog. (517 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (185 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
	SOX8	Transcription factor SOX-8. (471 aa)
	DLL3	Delta-like protein 3. (230 aa)
	PECAM1-1	Platelet endothelial cell adhesion molecule isoform A. (728 aa)
	MILR1	Allergin-1 isoform A. (337 aa)
	PKD1	Polycystin-1. (4307 aa)
	Y1Q_0016466	Uncharacterized protein. (4317 aa)
	AQP11	Aquaporin-11. (128 aa)
	HNF1B	Homeobox domain-containing protein. (562 aa)
	GREB1	Protein GREB1. (1950 aa)
	NPHS1L	Nephrin. (513 aa)
	IRX1	Iroquois-class homeodomain protein IRX-1. (307 aa)
	ZNF568-2	GDNF-inducible zinc finger protein 1-like. (794 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
	ZNF568	GDNF-inducible zinc finger protein 1. (702 aa)
	GREB1L	Uncharacterized protein. (1993 aa)
	Y1Q_0008043	Fork-head domain-containing protein. (90 aa)
	PTPRO	Receptor-type tyrosine-protein phosphatase O isoform B. (1189 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	NPHS1	Nephrin isoform B. (597 aa)
	FOXC2-1	Forkhead box protein C2 isoform B. (462 aa)
	DSPP	Dentin sialophosphoprotein isoform A. (931 aa)
	PKD2	EF-hand domain-containing protein. (818 aa)
	COMMD5	COMM domain-containing protein 5. (189 aa)
	NPM3	Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
	Y1Q_0023392	PDZ domain-containing protein. (102 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (379 aa)
	MAGI2	Uncharacterized protein. (1393 aa)
	PODXL-1	Podocalyxin isoform A. (328 aa)
	SMO	Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family. (804 aa)
	PAX8	Paired box protein Pax-8. (373 aa)
	FOXQ2	Forkhead box Q2. (207 aa)
	BASP1	Brain acid soluble protein 1. (244 aa)
	TMEM59L	Transmembrane protein 59-like. (297 aa)
	GLI3	Uncharacterized protein. (1572 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	Y1Q_0007371	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	MTSS1	Metastasis suppressor protein 1 isoform B. (788 aa)
	EDNRA	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	AQP1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	BMP4	Bone morphogenetic protein 4. (348 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	CALB1	Calbindin. (262 aa)
	SMAD4	Mothers against decapentaplegic homolog. (559 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP1	AQP11	A0A151PD70	A0A151N4T6	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin-11.	0.599
AQP11	AQP1	A0A151N4T6	A0A151PD70	Aquaporin-11.	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.599
BASP1	WT1	A0A151NXF7	A0A151MBS6	Brain acid soluble protein 1.	Wilms tumor protein-like protein isoform A.	0.416
BMP4	GREM1	A0A151PDY0	A0A151MUT8	Bone morphogenetic protein 4.	Gremlin-1.	0.918
BMP4	PTCH1	A0A151PDY0	A0A151M873	Bone morphogenetic protein 4.	Patched-like protein 1.	0.525
BMP4	SMAD4	A0A151PDY0	A0A151PJG8	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.820
BMP4	SMO	A0A151PDY0	A0A151NPV6	Bone morphogenetic protein 4.	Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.501
BMP4	WNT1	A0A151PDY0	A0A151N0A0	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.431
BMP4	Y1Q_0009747	A0A151PDY0	A0A151MWM4	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.707
CTNNB1	DLL1	A0A151P2N9	A0A151M2K3	Catenin beta-1 isoform B.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.413
CTNNB1	ILK	A0A151P2N9	A0A151MYS5	Catenin beta-1 isoform B.	Integrin-linked protein kinase.	0.418
CTNNB1	JAG1-2	A0A151P2N9	A0A151MGW0	Catenin beta-1 isoform B.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.423
CTNNB1	MAGI2	A0A151P2N9	A0A151NPN6	Catenin beta-1 isoform B.	Uncharacterized protein.	0.507
CTNNB1	MILR1	A0A151P2N9	A0A151N2G9	Catenin beta-1 isoform B.	Allergin-1 isoform A.	0.617
CTNNB1	NPM3	A0A151P2N9	A0A151NP53	Catenin beta-1 isoform B.	Nucleoplasmin-3; Belongs to the heparin-binding growth factors family.	0.408
CTNNB1	PECAM1-1	A0A151P2N9	A0A151N2D4	Catenin beta-1 isoform B.	Platelet endothelial cell adhesion molecule isoform A.	0.617
CTNNB1	SMAD4	A0A151P2N9	A0A151PJG8	Catenin beta-1 isoform B.	Mothers against decapentaplegic homolog.	0.621
CTNNB1	SMO	A0A151P2N9	A0A151NPV6	Catenin beta-1 isoform B.	Smoothened-like protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.427
CTNNB1	SOX8	A0A151P2N9	A0A151N207	Catenin beta-1 isoform B.	Transcription factor SOX-8.	0.591
CTNNB1	WNT1	A0A151P2N9	A0A151N0A0	Catenin beta-1 isoform B.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.801