STRINGSTRING
SOX18 SOX18 TGFBR2 TGFBR2 PDCD2 PDCD2 CDKN2C CDKN2C PTCH1 PTCH1 ATXN1L ATXN1L FGF4 FGF4 FERMT1 FERMT1 EIF2AK2 EIF2AK2 NR2E1 NR2E1 TP63 TP63 SOX17 SOX17 N4BP2L2 N4BP2L2 TGFBR2-2 TGFBR2-2 TP53 TP53 WNT1 WNT1 NF2 NF2 Y1Q_0007089 Y1Q_0007089 NF1 NF1 CCNE1 CCNE1 PTPRC PTPRC TERT TERT KDF1 KDF1 NPM3 NPM3 DGCR8 DGCR8 SIRT6 SIRT6 TGFB1 TGFB1 GLI3 GLI3 FBLN1 FBLN1 KDR KDR VEGFC VEGFC FERMT2 FERMT2 HMGA2 HMGA2 ZMPSTE24 ZMPSTE24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX18Transcription factor SOX-18. (392 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PDCD2Programmed cell death protein 2. (311 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (170 aa)
PTCH1Patched-like protein 1. (1479 aa)
ATXN1LAtaxin-1-like. (603 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
FERMT1PH domain-containing protein. (628 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (532 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
SOX17Sox C-terminal domain-containing protein. (232 aa)
N4BP2L2NEDD4-binding protein 2-like 2 isoform A. (768 aa)
TGFBR2-2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (546 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
NF2Merlin isoform A. (593 aa)
Y1Q_0007089FERM domain-containing protein. (665 aa)
NF1Neurofibromin isoform B. (2879 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (408 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform D. (1209 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (599 aa)
KDF1Keratinocyte differentiation factor 1. (401 aa)
NPM3Nucleoplasmin-3; Belongs to the heparin-binding growth factors family. (345 aa)
DGCR8Microprocessor complex subunit DGCR8. (775 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (357 aa)
TGFB1TGF_BETA_2 domain-containing protein. (242 aa)
GLI3Uncharacterized protein. (1572 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (713 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1353 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (414 aa)
FERMT2Fermitin family-like protein 2. (680 aa)
HMGA2High mobility group protein HMGI-C. (112 aa)
ZMPSTE24CAAX prenyl protease 1-like protein. (1233 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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