STRINGSTRING
PLA2R1 PLA2R1 SMC5 SMC5 PML PML ARNTL ARNTL TP63 TP63 BRCA2 BRCA2 TP53 TP53 TBX3 TBX3 WRN WRN MNT MNT TBX2 TBX2 PRELP PRELP MAPKAPK5 MAPKAPK5 OPA1 OPA1 ECRG4A ECRG4A SIRT1 SIRT1 NSMCE2 NSMCE2 WNT16 WNT16 HMGA2 HMGA2 SMC6 SMC6 Y1Q_0020266 Y1Q_0020266
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2R1Secretory phospholipase A2 receptor. (1303 aa)
SMC5Structural maintenance of chromosomes protein 5. (1028 aa)
PMLProtein PML isoform B. (586 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B. (651 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
BRCA2Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
TBX3T-box transcription factor TBX3. (501 aa)
WRNWerner syndrome ATP-dependent helicase. (1443 aa)
MNTMax-binding protein MNT. (423 aa)
TBX2T-box transcription factor TBX2. (507 aa)
PRELPProlargin. (385 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform B. (510 aa)
OPA1Dynamin-like protein, mitochondrial isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (905 aa)
ECRG4AAugurin-A. (149 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (634 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (291 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (255 aa)
HMGA2High mobility group protein HMGI-C. (112 aa)
SMC6Structural maintenance of chromosomes protein 6. (1125 aa)
Y1Q_0020266SMC_N domain-containing protein. (1136 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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