21 items (Alligator mississippiensis) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	PLA2R1	Secretory phospholipase A2 receptor. (1303 aa)
	SMC5	Structural maintenance of chromosomes protein 5. (1028 aa)
	PML	Protein PML isoform B. (586 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B. (651 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (730 aa)
	BRCA2	Breast cancer type 2 susceptibility protein isoform A. (1174 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	TBX3	T-box transcription factor TBX3. (501 aa)
	WRN	Werner syndrome ATP-dependent helicase. (1443 aa)
	MNT	Max-binding protein MNT. (423 aa)
	TBX2	T-box transcription factor TBX2. (507 aa)
	PRELP	Prolargin. (385 aa)
	MAPKAPK5	MAP kinase-activated protein kinase 5 isoform B. (510 aa)
	OPA1	Dynamin-like protein, mitochondrial isoform A; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (905 aa)
	ECRG4A	Augurin-A. (149 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (634 aa)
	NSMCE2	E3 SUMO-protein ligase NSE2. (291 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (255 aa)
	HMGA2	High mobility group protein HMGI-C. (112 aa)
	SMC6	Structural maintenance of chromosomes protein 6. (1125 aa)
	Y1Q_0020266	SMC_N domain-containing protein. (1136 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	SIRT1	A0A151MBX1	A0A151P0R7	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B.	NAD-dependent protein deacetylase sirtuin-1.	0.821
BRCA2	SMC5	A0A151MPE0	A0A151M8E7	Breast cancer type 2 susceptibility protein isoform A.	Structural maintenance of chromosomes protein 5.	0.412
BRCA2	SMC6	A0A151MPE0	A0A151PJA3	Breast cancer type 2 susceptibility protein isoform A.	Structural maintenance of chromosomes protein 6.	0.432
BRCA2	TP53	A0A151MPE0	A0A151MW63	Breast cancer type 2 susceptibility protein isoform A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.876
BRCA2	TP63	A0A151MPE0	A0A151MM54	Breast cancer type 2 susceptibility protein isoform A.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.486
BRCA2	WRN	A0A151MPE0	A0A151N5D4	Breast cancer type 2 susceptibility protein isoform A.	Werner syndrome ATP-dependent helicase.	0.981
HMGA2	TP53	A0A151PFG5	A0A151MW63	High mobility group protein HMGI-C.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.478
MAPKAPK5	TP53	A0A151NS49	A0A151MW63	MAP kinase-activated protein kinase 5 isoform B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.520
NSMCE2	SMC5	A0A151P7U7	A0A151M8E7	E3 SUMO-protein ligase NSE2.	Structural maintenance of chromosomes protein 5.	0.999
NSMCE2	SMC6	A0A151P7U7	A0A151PJA3	E3 SUMO-protein ligase NSE2.	Structural maintenance of chromosomes protein 6.	0.957
NSMCE2	WRN	A0A151P7U7	A0A151N5D4	E3 SUMO-protein ligase NSE2.	Werner syndrome ATP-dependent helicase.	0.694
NSMCE2	Y1Q_0020266	A0A151P7U7	A0A151PJG6	E3 SUMO-protein ligase NSE2.	SMC_N domain-containing protein.	0.957
PML	TP53	A0A151MAJ2	A0A151MW63	Protein PML isoform B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.850
SIRT1	ARNTL	A0A151P0R7	A0A151MBX1	NAD-dependent protein deacetylase sirtuin-1.	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B.	0.821
SIRT1	TP53	A0A151P0R7	A0A151MW63	NAD-dependent protein deacetylase sirtuin-1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.991
SIRT1	WRN	A0A151P0R7	A0A151N5D4	NAD-dependent protein deacetylase sirtuin-1.	Werner syndrome ATP-dependent helicase.	0.742
SMC5	BRCA2	A0A151M8E7	A0A151MPE0	Structural maintenance of chromosomes protein 5.	Breast cancer type 2 susceptibility protein isoform A.	0.412
SMC5	NSMCE2	A0A151M8E7	A0A151P7U7	Structural maintenance of chromosomes protein 5.	E3 SUMO-protein ligase NSE2.	0.999
SMC5	SMC6	A0A151M8E7	A0A151PJA3	Structural maintenance of chromosomes protein 5.	Structural maintenance of chromosomes protein 6.	0.974
SMC5	WRN	A0A151M8E7	A0A151N5D4	Structural maintenance of chromosomes protein 5.	Werner syndrome ATP-dependent helicase.	0.811