STRINGSTRING
MED15L MED15L MNAT1 MNAT1 HLF HLF MED9 MED9 TRRAP TRRAP MED25 MED25 MED8 MED8 FOSL1 FOSL1 ERCC2 ERCC2 TAF10 TAF10 MED11 MED11 MED30 MED30 TAF2 TAF2 SMAD7 SMAD7 SMAD2-2 SMAD2-2 Y1Q_0009747 Y1Q_0009747 NFE2 NFE2 BACH2 BACH2 ATF1 ATF1 TAF6-1 TAF6-1 CREB3 CREB3 Y1Q_0019270 Y1Q_0019270 SMAD5 SMAD5 RFXAP RFXAP CEBPD CEBPD MAX MAX RFXANK RFXANK CBFB CBFB FOS FOS LEF1 LEF1 RXRA RXRA GTF2F2 GTF2F2 ITM2B ITM2B MED4 MED4 CEBPZ CEBPZ DBP DBP NR5A1 NR5A1 Y1Q_0005761 Y1Q_0005761 MED22 MED22 MED7 MED7 GEMIN5 GEMIN5 BACH1 BACH1 BCL9 BCL9 GTF2E1 GTF2E1 TAF13 TAF13 GTF2H1 GTF2H1 Y1Q_0000673 Y1Q_0000673 ARNTL ARNTL E2F8-1 E2F8-1 NR1H3 NR1H3 MED6 MED6 TRIP4 TRIP4 GTF2A2 GTF2A2 SMAD3 SMAD3 SMAD6 SMAD6 SMAD2 SMAD2 TCF7 TCF7 NKX2-5 NKX2-5 GTF2H4 GTF2H4 GTF2A1 GTF2A1 GTF2B GTF2B DR1 DR1 TAF6L TAF6L TBPL1 TBPL1 MED23 MED23 TAF5L TAF5L GTF2H5 GTF2H5 ERCC3 ERCC3 ATF2 ATF2 NFE2L2 NFE2L2 DRAP1 DRAP1 MAFG MAFG TCF7L1 TCF7L1 Y1Q_0007599 Y1Q_0007599 TFDP2 TFDP2 HLTF HLTF STAT1 STAT1 SUPT3H SUPT3H TAF8-1 TAF8-1 NR5A2 NR5A2 MED10 MED10 Y1Q_0016705 Y1Q_0016705 E2F2-1 E2F2-1 POU2AF1 POU2AF1 ATF4-2 ATF4-2 MAFF MAFF NFYB-1 NFYB-1 ASCL4 ASCL4 ATF4-1 ATF4-1 ASCL1 ASCL1 XBP1 XBP1 HAND1 HAND1 WWOX WWOX IRF9 IRF9 Y1Q_0010299 Y1Q_0010299 TAF7L TAF7L TAF9B TAF9B TAF3 TAF3 CEBPE CEBPE MED14 MED14 GTF2H3 GTF2H3 ATF6 ATF6 ASCC3-2 ASCC3-2 TAF1 TAF1 TCF7L2 TCF7L2 TAF5 TAF5 GTF2F1 GTF2F1 MXI1-1 MXI1-1 GTF2A1L GTF2A1L NPAS2 NPAS2 TAF11 TAF11 MED26 MED26 ATF7 ATF7 BATF2 BATF2 TAF4 TAF4 ADNP ADNP CEBPB CEBPB NFATC1L NFATC1L Y1Q_0022523 Y1Q_0022523 JUNB JUNB MED16 MED16 BCL9L-1 BCL9L-1 Y1Q_0012446 Y1Q_0012446 Y1Q_0017512 Y1Q_0017512 Y1Q_0017513 Y1Q_0017513 CTNNB1 CTNNB1 MED17 MED17 FOSL2 FOSL2 ATF3 ATF3 FOXH1 FOXH1 Y1Q_0020693 Y1Q_0020693 NFYA-1 NFYA-1 VDR VDR MED1 MED1 MED1-2 MED1-2 HOXB9-1 HOXB9-1 MED24 MED24 STAT3 STAT3 E2F1 E2F1 Y1Q_0021645 Y1Q_0021645 ING2 ING2 PASD1 PASD1 SMAD1 SMAD1 STAT4 STAT4 CREM-1 CREM-1 E2F7 E2F7 Y1Q_0024421 Y1Q_0024421 NFYC NFYC TAF4B TAF4B JUND JUND E2F5 E2F5 ATF5 ATF5 CDK7 CDK7 GTF2H2 GTF2H2 CCNH CCNH MED18 MED18 SMAD4 SMAD4 ATF6B ATF6B Y1Q_0006875 Y1Q_0006875 c-jun c-jun PYGO2 PYGO2 STAT4-2 STAT4-2 CREB1 CREB1 Y1Q_0008677 Y1Q_0008677 E2F6-1 E2F6-1 RXRB RXRB PASD1-2 PASD1-2 Y1Q_0007802 Y1Q_0007802 CEBPG CEBPG CEBPA CEBPA MED31 MED31 ASCC2-1 ASCC2-1 ASCC2-2 ASCC2-2 MED15 MED15
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
MED15LMediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (162 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
HLFHepatic leukemia factor. (294 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (97 aa)
TRRAPTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3770 aa)
MED25Mediator of RNA polymerase II transcription subunit 25 isoform A. (612 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (343 aa)
FOSL1Fos-related antigen 1. (272 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit. (795 aa)
TAF10Transcription initiation factor TFIID subunit 10. (121 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (117 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (179 aa)
TAF2Transcription initiation factor TFIID subunit 2. (1145 aa)
SMAD7Mothers against decapentaplegic homolog. (384 aa)
SMAD2-2Mothers against decapentaplegic homolog. (512 aa)
Y1Q_0009747Mothers against decapentaplegic homolog. (517 aa)
NFE2Transcription factor NF-E2 subunit. (484 aa)
BACH2Transcription regulator protein BACH2. (605 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (330 aa)
TAF6-1Transcription initiation factor TFIID subunit 6 isoform A. (666 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (368 aa)
Y1Q_0019270Uncharacterized protein. (164 aa)
SMAD5Mothers against decapentaplegic homolog. (490 aa)
RFXAPRegulatory factor X-associated protein. (116 aa)
CEBPDCCAAT/enhancer-binding protein delta. (124 aa)
MAXProtein max. (151 aa)
RFXANKDNA-binding protein RFXANK. (309 aa)
CBFBCore-binding factor subunit beta. (187 aa)
FOSProto-oncogene c-Fos isoform A. (530 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform B. (391 aa)
RXRARetinoic acid receptor RXR-alpha. (467 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (261 aa)
ITM2BIntegral membrane protein 2B isoform B. (1151 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (256 aa)
CEBPZCCAAT/enhancer-binding protein zeta. (1049 aa)
DBPD site-binding protein. (307 aa)
NR5A1Uncharacterized protein. (466 aa)
Y1Q_0005761Uncharacterized protein. (485 aa)
MED22Mediator of RNA polymerase II transcription subunit 22. (214 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (230 aa)
GEMIN5Gem-associated protein 5 isoform A. (1507 aa)
BACH1Transcription regulator protein BACH1 isoform A. (665 aa)
BCL9B-cell CLL/lymphoma 9 protein. (1427 aa)
GTF2E1General transcription factor IIE subunit 1. (391 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
GTF2H1L-lactate dehydrogenase. (910 aa)
Y1Q_0000673Uncharacterized protein. (110 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform B. (651 aa)
E2F8-1Transcription factor E2F8 isoform B. (882 aa)
NR1H3Oxysterols receptor LXR-alpha. (408 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (246 aa)
TRIP4Activating signal cointegrator 1. (572 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
SMAD6Mothers against decapentaplegic homolog. (265 aa)
SMAD2Mothers against decapentaplegic homolog. (474 aa)
TCF7Transcription factor 7 isoform A. (452 aa)
NKX2-5Homeobox protein Nkx-2.5. (257 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (404 aa)
GTF2A1Transcription initiation factor IIA subunit 1. (375 aa)
GTF2BTranscription initiation factor IIB. (316 aa)
DR1Protein Dr1. (176 aa)
TAF6LTAF6-like RNA polymerase II p300/CBP-associated factor-associated factor subunit 6L. (629 aa)
TBPL1TATA box-binding protein-like protein 1. (255 aa)
MED23Mediator of RNA polymerase II transcription subunit 23. (1377 aa)
TAF5LTAF5-like RNA polymerase II p300/CBP-associated factor-associated factor subunit 5L. (576 aa)
GTF2H5General transcription factor IIH subunit 5. (115 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (779 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (458 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2. (482 aa)
DRAP1Dr1-associated corepressor. (219 aa)
MAFGTranscription factor MafG. (162 aa)
TCF7L1Transcription factor 7-like 1 isoform D. (567 aa)
Y1Q_0007599Uncharacterized protein. (420 aa)
TFDP2Transcription factor. (447 aa)
HLTFHelicase-like transcription factor. (990 aa)
STAT1Signal transducer and activator of transcription. (753 aa)
SUPT3HTranscription initiation SPT3-like protein. (346 aa)
TAF8-1Transcription initiation factor TFIID subunit 8 isoform B; Belongs to the glycosyl hydrolase 18 family. (774 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (539 aa)
MED10Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (134 aa)
Y1Q_0016705Mothers against decapentaplegic-like protein 6-like. (215 aa)
E2F2-1Transcription factor E2F2 isoform A. (382 aa)
POU2AF1POU domain class 2-associating factor 1 isoform B. (563 aa)
ATF4-2Cyclic AMP-dependent transcription factor ATF-4. (124 aa)
MAFFTranscription factor MafF. (149 aa)
NFYB-1Nuclear transcription factor Y subunit beta isoform B. (229 aa)
ASCL4Achaete-scute-like protein 4. (187 aa)
ATF4-1Cyclic AMP-dependent transcription factor ATF-4. (117 aa)
ASCL1Achaete-scute-like protein 1. (208 aa)
XBP1X-box-binding protein 1. (286 aa)
HAND1Heart-and neural crest derivatives-expressed protein 1. (183 aa)
WWOXWW domain-containing oxidoreductase isoform B. (440 aa)
IRF9Interferon regulatory factor 9 isoform A. (401 aa)
Y1Q_0010299Uncharacterized protein. (88 aa)
TAF7LTranscription initiation factor TFIID subunit 7-like. (353 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (255 aa)
TAF3Transcription initiation factor TFIID subunit 3 isoform C. (1040 aa)
CEBPECCAAT/enhancer-binding protein epsilon. (109 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1451 aa)
GTF2H3General transcription factor IIH subunit 3. (328 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (673 aa)
ASCC3-2Uncharacterized protein. (2288 aa)
TAF1Transcription initiation factor TFIID subunit. (1966 aa)
TCF7L2Transcription factor 7-like 2 isoform A. (411 aa)
TAF5Transcription initiation factor TFIID subunit 5. (655 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (627 aa)
MXI1-1Max-interacting protein 1 isoform A. (274 aa)
GTF2A1LTFIIA-alpha and beta-like factor. (488 aa)
NPAS2Uncharacterized protein. (936 aa)
TAF11Transcription initiation factor TFIID subunit 11. (153 aa)
MED26Mediator of RNA polymerase II transcription subunit 26. (164 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7. (482 aa)
BATF2Basic leucine zipper transcriptional factor ATF-like 2 isoform B. (120 aa)
TAF4Transcription initiation factor TFIID subunit 4. (976 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1122 aa)
CEBPBCCAAT/enhancer-binding protein beta. (141 aa)
NFATC1LNuclear factor of activated T-cells, cytoplasmic 1. (929 aa)
Y1Q_0022523Uncharacterized protein. (291 aa)
JUNBTranscription factor jun-B. (292 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (830 aa)
BCL9L-1B-cell CLL/lymphoma 9-like protein isoform B. (1409 aa)
Y1Q_0012446Uncharacterized protein. (535 aa)
Y1Q_0017512Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (345 aa)
Y1Q_0017513Mediator of RNA polymerase II transcription subunit 1-like. (204 aa)
CTNNB1Catenin beta-1 isoform B. (783 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (644 aa)
FOSL2Fos-related antigen 2. (253 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (220 aa)
FOXH1Forkhead box protein H1. (310 aa)
Y1Q_0020693Forkhead box protein H1. (75 aa)
NFYA-1Nuclear transcription factor Y subunit alpha isoform C. (346 aa)
VDRVitamin D3 receptor isoform B. (480 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1104 aa)
MED1-2Uncharacterized protein. (259 aa)
HOXB9-1Homeobox protein Hox-B9 isoform A. (255 aa)
MED24Mediator of RNA polymerase II transcription subunit 24 isoform B. (988 aa)
STAT3Signal transducer and activator of transcription. (727 aa)
E2F1Transcription factor E2F1. (426 aa)
Y1Q_0021645General transcription factor IIE subunit 1-like. (221 aa)
ING2Inhibitor of growth protein. (228 aa)
PASD1Circadian clock protein PASD1. (732 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
STAT4Signal transducer and activator of transcription. (849 aa)
CREM-1cAMP-responsive element modulator isoform B. (370 aa)
E2F7Transcription factor E2F7. (906 aa)
Y1Q_0024421Med25_NR-box domain-containing protein. (150 aa)
NFYCNuclear transcription factor Y subunit gamma isoform A. (367 aa)
TAF4BProteasome endopeptidase complex; Belongs to the peptidase T1A family. (1010 aa)
JUNDBZIP domain-containing protein. (87 aa)
E2F5Transcription factor E2F5. (386 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (293 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
CCNHCyclin-H; Belongs to the cyclin family. (247 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (559 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (666 aa)
Y1Q_0006875TFIIE-A_C domain-containing protein. (604 aa)
c-junTranscription factor AP-1; Belongs to the bZIP family. (320 aa)
PYGO2Pygopus-like protein 2. (371 aa)
STAT4-2Signal transducer and activator of transcription. (742 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
Y1Q_0008677WD_REPEATS_REGION domain-containing protein. (94 aa)
E2F6-1Transcription factor E2F6 isoform C. (429 aa)
RXRBUncharacterized protein. (449 aa)
PASD1-2Uncharacterized protein. (822 aa)
Y1Q_0007802Transcription initiation factor TFIID subunit 4-like. (750 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (150 aa)
CEBPACCAAT/enhancer-binding protein. (317 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (125 aa)
ASCC2-1Activating signal cointegrator 1 complex subunit 2 isoform A. (340 aa)
ASCC2-2Activating signal cointegrator 1 complex subunit 2. (400 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (412 aa)
Your Current Organism:
Alligator mississippiensis
NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator
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