(50 nodes) Protein complex involved in cell adhesion network (Alligator mississippiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGAV	Integrin alpha-V; Belongs to the integrin alpha chain family. (1030 aa)
	ITGA4	Integrin alpha-4; Belongs to the integrin alpha chain family. (1036 aa)
	ITGA3	Integrin alpha-3 isoform A; Belongs to the integrin alpha chain family. (1047 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (789 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	LAMB2	Uncharacterized protein. (1523 aa)
	ITGA10	Integrin alpha-10 isoform A; Belongs to the integrin alpha chain family. (1191 aa)
	TSPAN32	Tetraspanin-32; Belongs to the tetraspanin (TM4SF) family. (220 aa)
	JAM2	Junctional adhesion molecule B. (298 aa)
	Y1Q_0005609	Uncharacterized protein. (1687 aa)
	TNN	Tenascin-N. (1357 aa)
	Y1Q_0018549	Uncharacterized protein. (202 aa)
	TNW	Tenascin-N isoform A. (1314 aa)
	LYN	Tyrosine-protein kinase. (562 aa)
	ITGB8-1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	ITGA5	Integrin alpha-5. (671 aa)
	Y1Q_0010258	Integrin beta. (267 aa)
	ITGAL	Integrin alpha-L isoform C; Belongs to the integrin alpha chain family. (921 aa)
	ITGA1	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1137 aa)
	ITGA2	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1223 aa)
	EMILIN1	EMILIN-1. (1017 aa)
	ITGB4	Integrin beta. (1833 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4. (245 aa)
	ITGB2	Integrin beta. (778 aa)
	ITGAV-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1046 aa)
	ITGAE	Integrin alpha-E isoform A; Belongs to the integrin alpha chain family. (1215 aa)
	Y1Q_0016046	UPAR/Ly6 domain-containing protein. (123 aa)
	PLAUR	Urokinase plasminogen activator surface receptor. (945 aa)
	Y1Q_0018553	Integrin alpha-5-like. (167 aa)
	Y1Q_0008554	Uncharacterized protein. (295 aa)
	Y1Q_0008553	UPAR/Ly6 domain-containing protein. (221 aa)
	LGALS2	Galectin. (131 aa)
	MMRN1	Multimerin-1 isoform A. (1155 aa)
	ITGA7	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (808 aa)
	JAM3	Junctional adhesion molecule C. (319 aa)
	ITGB7	Integrin beta. (351 aa)
	Y1Q_0008577	Urokinase plasminogen activator surface receptor-like. (306 aa)
	Y1Q_0008576	UPAR/Ly6 domain-containing protein. (159 aa)
	Y1Q_0004465	VWFA domain-containing protein. (270 aa)
	VTN	Vitronectin. (324 aa)
	ITGA10-2	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (893 aa)
	ITGAD-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (878 aa)
	ITGAD	Integrin alpha-D; Belongs to the integrin alpha chain family. (1153 aa)
	ITGA9	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1002 aa)
	Y1Q_0013332	Integrin_alpha2 domain-containing protein. (279 aa)
	Y1Q_0019921	VWFA domain-containing protein. (212 aa)
	ITGA3-2	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1085 aa)
	ITGB3-2	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (881 aa)
	Y1Q_0012382	Uncharacterized protein. (283 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTLA4	LYN	A0A151N9A8	A0A151MNT0	Cytotoxic T-lymphocyte protein 4.	Tyrosine-protein kinase.	0.494
ITGA1	ITGA10	A0A151MX09	A0A151M8W1	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-10 isoform A; Belongs to the integrin alpha chain family.	0.563
ITGA1	ITGA10-2	A0A151MX09	A0A151NYD5	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.563
ITGA1	ITGA2	A0A151MX09	A0A151MXA2	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	0.581
ITGA1	ITGA3	A0A151MX09	A0A151LZZ5	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-3 isoform A; Belongs to the integrin alpha chain family.	0.523
ITGA1	ITGA3-2	A0A151MX09	A0A151P5Q2	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.660
ITGA1	ITGA4	A0A151MX09	A0A151LZP9	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-4; Belongs to the integrin alpha chain family.	0.595
ITGA1	ITGA5	A0A151MX09	A0A151MRH6	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-5.	0.523
ITGA1	ITGA7	A0A151MX09	A0A151NN37	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.523
ITGA1	ITGA9	A0A151MX09	A0A151P2L9	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.543
ITGA1	ITGAD	A0A151MX09	A0A151P0G8	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-D; Belongs to the integrin alpha chain family.	0.460
ITGA1	ITGAD-2	A0A151MX09	A0A151P066	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.460
ITGA1	ITGAE	A0A151MX09	A0A151NAE8	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-E isoform A; Belongs to the integrin alpha chain family.	0.460
ITGA1	ITGAL	A0A151MX09	A0A151MUR1	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-L isoform C; Belongs to the integrin alpha chain family.	0.460
ITGA1	ITGAV	A0A151MX09	A0A151MPY8	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin alpha-V; Belongs to the integrin alpha chain family.	0.477
ITGA1	ITGAV-2	A0A151MX09	A0A151NA84	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	0.576
ITGA1	ITGB1	A0A151MX09	A0A151PD43	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.954
ITGA1	ITGB2	A0A151MX09	A0A151N9X0	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta.	0.799
ITGA1	ITGB3	A0A151MX09	A0A151M0A8	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.758
ITGA1	ITGB3-2	A0A151MX09	A0A151PBV2	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.843