(43 nodes) Schaffer collateral - CA1 synapse network (Alligator mississippiensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	CDH11	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
	GRASP	General receptor for phosphoinositides 1-associated scaffold protein. (309 aa)
	Y1Q_0012383	Uncharacterized protein. (85 aa)
	Y1Q_0009653	DH domain-containing protein. (123 aa)
	NTNG1	Netrin-G1. (458 aa)
	IQSEC1	IQ motif and SEC7 domain-containing protein 1. (553 aa)
	APBA1	Uncharacterized protein. (823 aa)
	DGKZ	Diacylglycerol kinase. (1022 aa)
	NTNG2	Netrin-G2 isoform B. (552 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (589 aa)
	PPP3R1	Calcineurin subunit B type 1. (170 aa)
	TNN	Tenascin-N. (1357 aa)
	NPTN	Neuroplastin. (270 aa)
	Y1Q_0012280	Uncharacterized protein. (135 aa)
	DTNBP1	Dysbindin. (352 aa)
	GRM5	G_PROTEIN_RECEP_F3_4 domain-containing protein. (1243 aa)
	PTPRA-2	Uncharacterized protein. (1013 aa)
	IQSEC3	IQ motif and SEC7 domain-containing protein 3 isoform A. (996 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
	PRKCZ-2	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
	BCR-2	Uncharacterized protein. (2542 aa)
	BCR	Breakpoint cluster region protein. (631 aa)
	Y1Q_0004744	Protein kinase domain-containing protein. (161 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (580 aa)
	CACNG2	Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (300 aa)
	Y1Q_0024247	ANK_REP_REGION domain-containing protein. (346 aa)
	DGKI	Diacylglycerol kinase. (675 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains protein 1 isoform A. (1730 aa)
	AKAP12	A-kinase anchor protein 12. (1999 aa)
	GRM1	G_PROTEIN_RECEP_F3_4 domain-containing protein. (1190 aa)
	Y1Q_0007228	Uncharacterized protein. (492 aa)
	CASK	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family. (926 aa)
	Y1Q_0015722	Receptor-type tyrosine-protein phosphatase T-like. (566 aa)
	Y1Q_0015723	Uncharacterized protein. (379 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (413 aa)
	CACNG3	Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
	EFNB2	Ephrin-B2; Belongs to the ephrin family. (333 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
	CTNNB1	Catenin beta-1 isoform B. (783 aa)
	LRFN1	Leucine-rich repeat and fibronectin type III domain-containing protein 1. (763 aa)
	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform A. (541 aa)
	NEFL	Neurofilament light polypeptide; Belongs to the intermediate filament family. (550 aa)
	Y1Q_0014655	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1059 aa)

Your Current Organism:

Alligator mississippiensis

NCBI taxonomy Id: 8496
Other names: A. mississippiensis, American alligator

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	Y1Q_0014655	A0A151P235	A0A151P8F6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.606
APBA1	CASK	A0A151M8G4	A0A151NRK9	Uncharacterized protein.	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	0.995
BAIAP2	SHANK1	A0A151P440	A0A151NK00	Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform A.	SH3 and multiple ankyrin repeat domains protein 1 isoform A.	0.456
BCR	Y1Q_0009653	A0A151NAE9	A0A151LZE4	Breakpoint cluster region protein.	DH domain-containing protein.	0.933
CASK	APBA1	A0A151NRK9	A0A151M8G4	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	Uncharacterized protein.	0.995
CASK	GRASP	A0A151NRK9	A0A151LY21	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	General receptor for phosphoinositides 1-associated scaffold protein.	0.504
CASK	PPP3R1	A0A151NRK9	A0A151MH36	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	Calcineurin subunit B type 1.	0.705
CASK	PRKCZ	A0A151NRK9	A0A151MGD5	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.400
CASK	PRKCZ-2	A0A151NRK9	A0A151N4C3	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.400
CASK	SHANK1	A0A151NRK9	A0A151NK00	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains protein 1 isoform A.	0.649
CDH11	CTNNB1	A0A151N7C6	A0A151P2N9	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta-1 isoform B.	0.853
CTNNB1	CDH11	A0A151P2N9	A0A151N7C6	Catenin beta-1 isoform B.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.853
DGKI	Y1Q_0024247	A0A151NIP5	A0A151NIA1	Diacylglycerol kinase.	ANK_REP_REGION domain-containing protein.	0.900
GRASP	CASK	A0A151LY21	A0A151NRK9	General receptor for phosphoinositides 1-associated scaffold protein.	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	0.504
GRASP	PRKCZ	A0A151LY21	A0A151MGD5	General receptor for phosphoinositides 1-associated scaffold protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.435
GRASP	PRKCZ-2	A0A151LY21	A0A151N4C3	General receptor for phosphoinositides 1-associated scaffold protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.435
GRM1	GRM5	A0A151NLN2	A0A151MVG0	G_PROTEIN_RECEP_F3_4 domain-containing protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.902
GRM5	GRM1	A0A151MVG0	A0A151NLN2	G_PROTEIN_RECEP_F3_4 domain-containing protein.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.902
PPP3R1	CASK	A0A151MH36	A0A151NRK9	Calcineurin subunit B type 1.	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	0.705
PRKCZ	CASK	A0A151MGD5	A0A151NRK9	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Peripheral plasma membrane protein CASK isoform B; Belongs to the MAGUK family.	0.400